These results support the conclusion that CSP partial NH2-terminal domain can be endogenously expressed to promote a competition for the receptor used by sporozoites to invade salivary glands, and they could be used to block this interaction and reduce parasite transmission.
Experiments demonstrating the feasibility of genetically modifying mosquito vectors to impair their ability to transmit the malaria parasite have been known for well over a decade.
The application of mosquito coils did not necessarily reduce the incidence of malaria in the study communities.
After the existing public health system was reinforced with programmatic and logistic support, an intense 2-weekly distribution scheme of a vector control tool over a 2-year period was operated successfully in the field.
The results agree with previous studies showing that older insects are often more resistant to infections than younger ones.
Mosquitoes transmit several diseases which cause millions of deaths every year.
Priming in invertebrates is the acquired capacity to better combat a pathogen due to a previous exposure to sub-lethal doses of the same organism.
By expanding breeding-site coverage and boosting juvenile mosquito mortality, a strategy based on mosquito-disseminated PPF has potential to substantially enhance mosquito control.
Hematophagous vectors strictly require ingesting blood from their hosts to complete their life cycles
The mosquito, Anopheles coluzzii is a major vector of human malaria in Africa with widespread distribution throughout the continent.