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Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.

April 28, 2018 - 15:33 -- Open Access
Smit MR, Ochomo E, Ter Kuile FO, et al.
Lancet Infect Dis. 2018 Mar 27. pii: S1473-3099(18)30163-4.

Ivermectin has captured the imagination of a small group of global health scientists as one approach to solving the problem of residual transmission of malaria. This old, so-called wonder drug—an endectocide that targets both endoparasites and ectoparasites—was originally identified as a natural substance by Satoshi Ōmura of Kitasato Institute. The drug was further developed by William Campbell of Merck Labs as a potent anthelmintic, originally for use in veterinary health and targeting more than 20 species of helminth.


Quantifying seasonal and diel variation in Anopheline and Culex human biting rates in Southern Ecuador

November 25, 2017 - 14:38 -- Open Access
Sadie J. Ryan, Catherine A. Lippi, Anna M. Stewart-Ibarra, et al.
Malaria Journal 2017 16:479, 22 November 2017

Fine-scale differences in endophagy and exophagy, and temporal differences among months and hours exist in biting patterns among mosquito taxa in southern coastal Ecuador.


Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR

September 11, 2017 - 15:47 -- Open Access
Wouter Graumans, Fitsum G. Tadesse, Teun Bousema, et al.
Malaria Journal 2017 16:356, 6 September 2017

The proposed bead-beating CSP-ELISA/qPCR methodology considerably increases throughput for the detection of mosquito infection.

Affordable house designs to improve health in rural Africa: a field study from northeastern Tanzania

August 10, 2017 - 15:40 -- Open Access
Lorenz von Seidlein, Konstantin Ikonomedis, Jakob B Knudsen, et al.
The Lancet, Volume 1, No. 5, e188–e199, August 2017

The new design houses had fewer mosquitoes and were cooler than modified and unmodified traditional homes.


Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

August 8, 2017 - 11:19 -- Open Access
Isaie J. Reuling, Will J. R. Stone, Robert W. Sauerwein, et al.
Malaria Journal 2017 16:315, 5 August 2017

The current study demonstrates that concentration methods of P. falciparum gametocyte-infected whole blood samples can enhance transmission in mosquito-feeding assays.

Medical Condition: 

NOT Open Access | Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes

July 29, 2017 - 16:05 -- NOT Open Access
Lynn D. Blake, Myles E. Johnson, Dennis E. Kyle, et al.
Antimicrob. Agents Chemother. August 2017 vol. 61 no. 8 e00689-17

Malaria-related mortality has slowly decreased over the past decade; however, eradication of malaria requires the development of new antimalarial chemotherapies that target liver stages of the parasite and combat the emergence of drug resistance.

Measuring, manipulating and exploiting behaviours of adult mosquitoes to optimise malaria vector control impact

May 25, 2017 - 09:10 -- Open Access
Gerry F Killeen, John M Marshall, Samson S Kiware, Andy B South, Lucy S Tusting, Prosper P Chaki, Nicodem J Govella
BMJ Global Healthm April 26, 2017, 2 (2) e000212

Residual malaria transmission can persist despite high coverage with effective long-lasting insecticidal nets (LLINs) and/or indoor residual spraying (IRS), because many vector mosquitoes evade them by feeding on animals, feeding outdoors, resting outdoors or rapidly exiting from houses after entering them.

Medical Treatment: 

Control of Malaria Vector Mosquitoes by Insecticide-Treated Combinations of Window Screens and Eave Baffles

May 25, 2017 - 09:06 -- Open Access
Gerry F. Killeen, John P. Masalu, Dingani Chinula, Emmanouil A. Fotakis, Deogratius R. Kavishe, David Malone, and Fredros Okumu
Emerging Infectious Diseases, Volume 23, Number 5—May 2017

We assessed window screens and eave baffles (WSEBs), which enable mosquitoes to enter but not exit houses, as an alternative to indoor residual spraying (IRS) for malaria vector control.

The paradigm of eave tubes: scaling up house improvement and optimizing insecticide delivery against disease-transmitting mosquitoes

May 25, 2017 - 06:01 -- Open Access
Fredros Okumu
Malaria Journal 2017 16:207, 19 May 2017

Control of mosquito-borne diseases is greatly compromised by spread of insecticide resistance, high implementation costs and sub-optimal compliance among users.

Comparison of two adult mosquito sampling methods with human landing catches in south-central Ethiopia

January 17, 2017 - 15:30 -- Open Access
Oljira Kenea, Meshesha Balkew, Habte Tekie, Teshome Gebre-Michael, Wakgari Deressa, Eskindir Loha, Bernt Lindtjørn and Hans J. Overgaard
Malaria Journal 2017 16:30, 13 January 2017

Results showed that HLC was the most efficient method for sampling An. arabiensis.



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