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mosquitoes

Reduction of malaria vector mosquitoes in a large-scale intervention trial in rural Burkina Faso using Bti based larval source management

September 16, 2019 - 14:42 -- Open Access
Author(s): 
Peter Dambach, Till Baernighausen, Issouf Traoré, Saidou Ouedraogo, Ali Sié, Rainer Sauerborn, Norbert Becker and Valérie R. Louis
Reference: 
Malaria Journal 2019 18:311, 14 September 2019

Malaria remains one of the most important causes of morbidity and death in sub-Saharan Africa. Along with early diagnosis and treatment of malaria cases and intermittent preventive treatment in pregnancy (IPTp), vector control is an important tool in the reduction of new cases. Alongside the use of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), targeting the vector larvae with biological larvicides, such as Bacillus thuringiensis israelensis (Bti) is gaining importance as a means of reducing the number of mosquito larvae before they emerge to their adult stage. This study presents data corroborating the entomological impact of such an intervention in a rural African environment.

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Reducing malaria burden and accelerating elimination with long-lasting systemic insecticides: a modelling study of three potential use cases

September 13, 2019 - 06:55 -- Open Access
Author(s): 
Prashanth Selvaraj, Joshua Suresh, Edward A. Wenger, Caitlin A. Bever and Jaline Gerardin
Reference: 
Malaria Journal 2019 18:307, 5 September 2019

While bed nets and insecticide spraying have had significant impact on malaria burden in many endemic regions, outdoor vector feeding and insecticide resistance may ultimately limit their contribution to elimination and control campaigns. Complementary vector control methods such as endectocides or systemic insecticides, where humans or animals are treated with drugs that kill mosquitoes upon ingestion via blood meal, are therefore generating much interest. This work explores the conditions under which long-lasting systemic insecticides would have a substantial impact on transmission and burden.

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Knowledge engagement in gene drive research for malaria control

April 30, 2019 - 15:29 -- Open Access
Author(s): 
Sarah Hartley, Delphine Thizy, Katie Ledingham, Mamadou Coulibaly, Abdoulaye Diabaté, Bakara Dicko, Samba Diop, Jonathan Kayondo, Annet Namukwaya, Barry Nourou, Léa Paré Toé
Reference: 
PLoS Negl Trop Dis 13(4): e0007233

Gene drive mosquitoes are a novel approach to vector control being developed to help tackle malaria. A gene drive increases the frequency of a desired gene and its phenotypic effect into a mosquito population through reproduction in relatively few generations [1]. Combining gene drive with the precision of gene editing, scientists are able to modify the Anopheles mosquito genome and push modifications through natural vector populations. 

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‘The mosquitoes are preparing to attack us’: knowledge and perceptions of communities in south-eastern Tanzania regarding mosquito swarms

February 28, 2019 - 15:46 -- Open Access
Author(s): 
Marceline F. Finda, Emmanuel W. Kaindoa, Anna P. Nyoni and Fredros O. Okumu
Reference: 
Malaria Journal 2019 18:56, 26 February 2019

Majority of the community members recognized presence of mosquito swarms in their communities but did not associate these swarms with mosquito mating.

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Behavioral responses of gravid Culex quinquefasciatus, Aedes aegypti, and Anopheles quadrimaculatus mosquitoes to aquatic macrophyte volatiles

November 22, 2018 - 15:44 -- Open Access
Author(s): 
Rakim K. Turnipseed, Patrick J. Moran, Sandra A. Allan
Reference: 
Journal of Vector Ecology, Volume43, Issue2 December 2018 Pages 252-260

Mosquitoes use many cues to assess whether a habitat is conducive for reproduction, possibly including the presence of stimuli from aquatic macrophytes.

Assessing Plasmodium falciparum transmission in mosquito-feeding assays using quantitative PCR

July 6, 2018 - 16:49 -- Open Access
Author(s): 
Claire Y. T. Wang, James S. McCarthy, Will J. Stone, Teun Bousema, Katharine A. Collins and Seweryn Bialasiewicz
Reference: 
Malaria Journal 2018 17:249, 5 July 2018

This semi-automated qPCR method enables accurate detection of low-level P. falciparum oocyst infections in mosquito midguts, and may improve the sensitivity, specificity and throughput of assays used to evaluate candidate transmission-blocking interventions.

Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.

April 28, 2018 - 15:33 -- Open Access
Author(s): 
Smit MR, Ochomo E, Ter Kuile FO, et al.
Reference: 
Lancet Infect Dis. 2018 Mar 27. pii: S1473-3099(18)30163-4.

Ivermectin has captured the imagination of a small group of global health scientists as one approach to solving the problem of residual transmission of malaria. This old, so-called wonder drug—an endectocide that targets both endoparasites and ectoparasites—was originally identified as a natural substance by Satoshi Ōmura of Kitasato Institute. The drug was further developed by William Campbell of Merck Labs as a potent anthelmintic, originally for use in veterinary health and targeting more than 20 species of helminth.

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Quantifying seasonal and diel variation in Anopheline and Culex human biting rates in Southern Ecuador

November 25, 2017 - 14:38 -- Open Access
Author(s): 
Sadie J. Ryan, Catherine A. Lippi, Anna M. Stewart-Ibarra, et al.
Reference: 
Malaria Journal 2017 16:479, 22 November 2017

Fine-scale differences in endophagy and exophagy, and temporal differences among months and hours exist in biting patterns among mosquito taxa in southern coastal Ecuador.

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Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR

September 11, 2017 - 15:47 -- Open Access
Author(s): 
Wouter Graumans, Fitsum G. Tadesse, Teun Bousema, et al.
Reference: 
Malaria Journal 2017 16:356, 6 September 2017

The proposed bead-beating CSP-ELISA/qPCR methodology considerably increases throughput for the detection of mosquito infection.

Affordable house designs to improve health in rural Africa: a field study from northeastern Tanzania

August 10, 2017 - 15:40 -- Open Access
Author(s): 
Lorenz von Seidlein, Konstantin Ikonomedis, Jakob B Knudsen, et al.
Reference: 
The Lancet, Volume 1, No. 5, e188–e199, August 2017

The new design houses had fewer mosquitoes and were cooler than modified and unmodified traditional homes.

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