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mosquitoes

Knowledge engagement in gene drive research for malaria control

April 30, 2019 - 15:29 -- Open Access
Author(s): 
Sarah Hartley, Delphine Thizy, Katie Ledingham, Mamadou Coulibaly, Abdoulaye Diabaté, Bakara Dicko, Samba Diop, Jonathan Kayondo, Annet Namukwaya, Barry Nourou, Léa Paré Toé
Reference: 
PLoS Negl Trop Dis 13(4): e0007233

Gene drive mosquitoes are a novel approach to vector control being developed to help tackle malaria. A gene drive increases the frequency of a desired gene and its phenotypic effect into a mosquito population through reproduction in relatively few generations [1]. Combining gene drive with the precision of gene editing, scientists are able to modify the Anopheles mosquito genome and push modifications through natural vector populations. 

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‘The mosquitoes are preparing to attack us’: knowledge and perceptions of communities in south-eastern Tanzania regarding mosquito swarms

February 28, 2019 - 15:46 -- Open Access
Author(s): 
Marceline F. Finda, Emmanuel W. Kaindoa, Anna P. Nyoni and Fredros O. Okumu
Reference: 
Malaria Journal 2019 18:56, 26 February 2019

Majority of the community members recognized presence of mosquito swarms in their communities but did not associate these swarms with mosquito mating.

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Behavioral responses of gravid Culex quinquefasciatus, Aedes aegypti, and Anopheles quadrimaculatus mosquitoes to aquatic macrophyte volatiles

November 22, 2018 - 15:44 -- Open Access
Author(s): 
Rakim K. Turnipseed, Patrick J. Moran, Sandra A. Allan
Reference: 
Journal of Vector Ecology, Volume43, Issue2 December 2018 Pages 252-260

Mosquitoes use many cues to assess whether a habitat is conducive for reproduction, possibly including the presence of stimuli from aquatic macrophytes.

Assessing Plasmodium falciparum transmission in mosquito-feeding assays using quantitative PCR

July 6, 2018 - 16:49 -- Open Access
Author(s): 
Claire Y. T. Wang, James S. McCarthy, Will J. Stone, Teun Bousema, Katharine A. Collins and Seweryn Bialasiewicz
Reference: 
Malaria Journal 2018 17:249, 5 July 2018

This semi-automated qPCR method enables accurate detection of low-level P. falciparum oocyst infections in mosquito midguts, and may improve the sensitivity, specificity and throughput of assays used to evaluate candidate transmission-blocking interventions.

Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.

April 28, 2018 - 15:33 -- Open Access
Author(s): 
Smit MR, Ochomo E, Ter Kuile FO, et al.
Reference: 
Lancet Infect Dis. 2018 Mar 27. pii: S1473-3099(18)30163-4.

Ivermectin has captured the imagination of a small group of global health scientists as one approach to solving the problem of residual transmission of malaria. This old, so-called wonder drug—an endectocide that targets both endoparasites and ectoparasites—was originally identified as a natural substance by Satoshi Ōmura of Kitasato Institute. The drug was further developed by William Campbell of Merck Labs as a potent anthelmintic, originally for use in veterinary health and targeting more than 20 species of helminth.

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Quantifying seasonal and diel variation in Anopheline and Culex human biting rates in Southern Ecuador

November 25, 2017 - 14:38 -- Open Access
Author(s): 
Sadie J. Ryan, Catherine A. Lippi, Anna M. Stewart-Ibarra, et al.
Reference: 
Malaria Journal 2017 16:479, 22 November 2017

Fine-scale differences in endophagy and exophagy, and temporal differences among months and hours exist in biting patterns among mosquito taxa in southern coastal Ecuador.

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Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR

September 11, 2017 - 15:47 -- Open Access
Author(s): 
Wouter Graumans, Fitsum G. Tadesse, Teun Bousema, et al.
Reference: 
Malaria Journal 2017 16:356, 6 September 2017

The proposed bead-beating CSP-ELISA/qPCR methodology considerably increases throughput for the detection of mosquito infection.

Affordable house designs to improve health in rural Africa: a field study from northeastern Tanzania

August 10, 2017 - 15:40 -- Open Access
Author(s): 
Lorenz von Seidlein, Konstantin Ikonomedis, Jakob B Knudsen, et al.
Reference: 
The Lancet, Volume 1, No. 5, e188–e199, August 2017

The new design houses had fewer mosquitoes and were cooler than modified and unmodified traditional homes.

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Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

August 8, 2017 - 11:19 -- Open Access
Author(s): 
Isaie J. Reuling, Will J. R. Stone, Robert W. Sauerwein, et al.
Reference: 
Malaria Journal 2017 16:315, 5 August 2017

The current study demonstrates that concentration methods of P. falciparum gametocyte-infected whole blood samples can enhance transmission in mosquito-feeding assays.

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NOT Open Access | Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes

July 29, 2017 - 16:05 -- NOT Open Access
Author(s): 
Lynn D. Blake, Myles E. Johnson, Dennis E. Kyle, et al.
Reference: 
Antimicrob. Agents Chemother. August 2017 vol. 61 no. 8 e00689-17

Malaria-related mortality has slowly decreased over the past decade; however, eradication of malaria requires the development of new antimalarial chemotherapies that target liver stages of the parasite and combat the emergence of drug resistance.

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