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UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages

January 20, 2016 - 15:30 -- Open Access
Min Zhang, Satish Mishra, Ramanavelan Sakthivel, Beatriz M. A. Fontoura, Victor Nussenzweig
PLoS Pathog 12(1): e1005370

Plasmodium salivary sporozoites are the infectious form of the malaria parasite and are dormant inside salivary glands of Anopheles mosquitoes.

A paper and plastic device for the combined isothermal amplification and lateral flow detection of Plasmodium DNA

December 1, 2015 - 18:14 -- Open Access
Michael Cordray, Rebecca Richards-Kortum
Malaria Journal 2015, 14:472 (26 November 2015)

The device was capable of carrying out the RPA reaction and detecting meaningful amounts of synthetic Plasmodium DNA in a self-sealing and self-contained device.

NOT Open Access | Two independently folding units of Plasmodium profilin suggest evolution via gene fusion

October 20, 2015 - 07:28 -- NOT Open Access
Saligram Prabhakar Bhargav, Juha Vahokoski, Juha Pekka Kallio, Andrew E. Torda, Petri Kursula & Inari Kursula
Cellular and Molecular Life Sciences, November 2015, Volume 72, Issue 21, pp 4193-4203

Gene fusion is a common mechanism of protein evolution that has mainly been discussed in the context of multidomain or symmetric proteins.

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

October 5, 2015 - 16:49 -- Open Access
Jessica H. Chertow, Matthew S. Alkaitis, Hans Ackerman, et al.
PLoS Pathog 11(9): e1005119

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection.

IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells

July 15, 2015 - 10:11 -- Open Access
Stephanie M. Coomes, Victoria S. Pelly, Mark S. Wilson, et al.
PLoS Pathog 11(7): e1004994

Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas.

NOT Open Access | Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae

July 1, 2015 - 15:44 -- NOT Open Access
Ryan C. Smith, Carolina Barillas-Mury, and Marcelo Jacobs-Lorena
PNAS June 30, 2015 vol. 112 no. 26 E3412-E3420

Plasmodium parasites must complete development in the mosquito vector for transmission to occur.

Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor

June 2, 2015 - 13:28 -- Open Access
Izumi Kaneko, Shiroh Iwanaga, Tomomi Kato, Issei Kobayashi, Masao Yuda
PLoS Pathog 11(5): e1004905

Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite.


Not Open Access | A Simple Real-Time PCR and Amplicon Sequencing Method for Identification of Plasmodium Species in Human Whole Blood

May 20, 2015 - 15:12 -- NOT Open Access
Lefterova MI, Budvytiene I, Sandlund J, Färnert A, Banaei N
J Clin Microbiol. 2015 May 13. pii: JCM.00542-15.

Here we describe a SYBR Green-based real-time PCR assay for Plasmodium species identification from whole blood, which uses a panel of reactions to detect species-specific non-18S rRNA gene targets.

Not Open Access | Disruption of parasite hmgb2 gene attenuates Plasmodium berghei ANKA pathogenicity

April 28, 2015 - 16:47 -- NOT Open Access
Sylvie Briquet, Nadou Lawson-Hogban, Bertrand Boisson, Miguel P. Soares, Roger Péronet, Leanna Smith, Robert Ménard, Michel Huerre, Salah Mécheri, and Catherine Vaquero
Infect. Immun. 27 April 2015

We found that the Plasmodium genome encodes two genuine HMGB factors, Plasmodium HMGB1 and HMGB2 that encompass, as their human counterparts, a pro-inflammatory domain.


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