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plasmodium

The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo show different binding activity level to human erythrocytes

August 15, 2017 - 14:35 -- Open Access
Author(s): 
Khai Lone Lim, Amirah Amir, Yee Ling Lau and Mun Yik Fong
Reference: 
Malaria Journal 2017 16:331, 11 August 2017

This study is the first report of phenotypic difference between PkDBPαII haplotypes.

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NOT Open Access | An in silico strategy for identification of novel drug targets against Plasmodium falciparum

August 14, 2017 - 15:58 -- NOT Open Access
Author(s): 
Subhashree Rout, Namrata Priyadarshini Patra & Rajani Kanta Mahapatra
Reference: 
Parasitology Research, September 2017, Volume 116, Issue 9, pp 2539–2559

The apicomplexan parasite Plasmodium falciparum is responsible for global malaria burden. With the reported resistance to artemisinin chemotherapy, there is an urgent need to maintain early phase drug discovery and identify novel drug targets for successful eradication of the pathogen from the host.

Hydrophilic-treated plastic plates for wide-range analysis of Giemsa-stained red blood cells and automated Plasmodium infection rate counting

August 10, 2017 - 06:39 -- Open Access
Author(s): 
Muneaki Hashimoto, Shouki Yatsushiro, Masatoshi Kataoka, et al.
Reference: 
Malaria Journal 2017 16:321, 8 August 2017

Because the running cost of these methods is very low and they do not involve complicated techniques, the use of hydrophilic COC plates may contribute to improved and more accurate diagnosis and research of malaria.

Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs

May 25, 2017 - 08:09 -- Open Access
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Author(s): 
Amelia E. Hanron, Zachary P. Billman, Sean C. Murphy, et al.
Reference: 
Malaria Journal 2017 16:208, 19 May 2017

Because the spliced target does not require DNase treatment, the PF3D7_0630000 assay can be multiplexed with Plasmodium 18S rRNA for direct one-step detection of gametocytes from whole human blood.

High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations

April 25, 2017 - 15:50 -- Open Access
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Author(s): 
Yaye Dié Ndiaye, Cyrille K. Diédhiou, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2017 16:153, 19 April 2017

Here the results demonstrate that HRM is a rapid, sensitive, and field-deployable alternative technique to PCR–RFLP genotyping that is useful in populations harbouring more than one parasite genome (polygenomic infections).

Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale

February 22, 2017 - 14:49 -- Open Access
Author(s): 
André Golldack, Björn Henke, Bärbel Bergmann, Marie Wiechert, Holger Erler, Alexandra Blancke Soares, Tobias Spielmann, Eric Beitz
Reference: 
PLoS Pathog 13(2): e1006172

Resistance against all available antimalarial drugs calls for novel compounds that hit unexploited targets in the parasite.

A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle

January 17, 2017 - 15:43 -- Open Access
Author(s): 
Katarzyna Modrzynska, Claudia Pfander, Oliver Billker, et al.
Reference: 
Cell Host & Microbe, Volume 21, Issue 1, 11 January 2017, Pages 11–22

A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria parasites. This family includes sequence-specific transcription factors that are key regulators of development. However, functions for the majority of ApiAP2 genes remain unknown. Here, a systematic knockout screen in Plasmodium berghei identified ten ApiAP2 genes that were essential for mosquito transmission: four were critical for the formation of infectious ookinetes, and three were required for sporogony.

Plasmodium infection and oxidative status in breeding great tits, Parus major

November 9, 2016 - 17:20 -- Open Access
Tags: 
Author(s): 
Jessica Delhaye, Tania Jenkins and Philippe Christe
Reference: 
Malaria Journal 2016 15:531, 4 November 2016

The results suggest that Plasmodium parasites may impose a cost in terms of increased oxidative stress possibly mediated via a higher energy requirement in infected hosts.

Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

August 26, 2016 - 18:15 -- Open Access
Author(s): 
Akshay T. Krishnamurty, Christopher D. Thouvenel, Silvia Portugal, Gladys J. Keitany, Karen S. Kim, Anthony Holder, Peter D. Crompton, David J. Rawlings, Marion Pepper
Reference: 
Immunity, Volume 45, Issue 2, 16 August 2016, Pages 402–414

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBC).

NOT Open Access | Bistacrine derivatives as new potent antimalarials

July 23, 2016 - 17:59 -- NOT Open Access
Author(s): 
Ines Schmidt, Gabriele Pradel, Ludmilla Sologub, Alexandra Golzmann, Che J. Ngwa, Anna Kucharski, Tanja Schirmeister, Ulrike Holzgrabe
Reference: 
Bioorganic & Medicinal Chemistry, Volume 24, Issue 16, 15 August 2016, Pages 3636–3642

Linking two tacrine molecules results in a tremendous increase of activity against Plasmodia in comparison to the monomer.

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