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plasmodium

NOT Open Access | Structure- and function-based design of Plasmodium-selective proteasome inhibitors

February 15, 2016 - 18:17 -- NOT Open Access
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Author(s): 
Hao Li, Anthony J. O’Donoghue, Matthew Bogyo, et al.
Reference: 
Nature 530, 233–236 (11 February 2016)

The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation.

Consistent prevalence of asymptomatic infections in malaria endemic populations in Colombia over time

February 9, 2016 - 16:55 -- Open Access
Author(s): 
Juan M. Vásquez-Jiménez, Myriam Arévalo-Herrera, Juliana Henao-Giraldo, Karen Molina-Gómez, María Arce-Plata, Andrés F. Vallejo and Sócrates Herrera
Reference: 
Malaria Journal 2016 15:70, 6 February 2016

This study demonstrates an important prevalence of asymptomatic malaria cases not detectable by microscopy, which therefore remain untreated representing a parasite pool for malaria transmission.

Malaria and blood transfusion: major issues of blood safety in malaria-endemic countries and strategies for mitigating the risk of Plasmodium parasites

January 26, 2016 - 18:54 -- Open Access
Author(s): 
Saleh Abdullah & Kaliyaperumal Karunamoorthi
Reference: 
Parasitology Research, Volume 115, Issue 1 , pp 35-47

Malaria inflicts humankind over centuries, and it remains as a major threat to both clinical medicine and public health worldwide.

UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages

January 20, 2016 - 15:30 -- Open Access
Author(s): 
Min Zhang, Satish Mishra, Ramanavelan Sakthivel, Beatriz M. A. Fontoura, Victor Nussenzweig
Reference: 
PLoS Pathog 12(1): e1005370

Plasmodium salivary sporozoites are the infectious form of the malaria parasite and are dormant inside salivary glands of Anopheles mosquitoes.

A paper and plastic device for the combined isothermal amplification and lateral flow detection of Plasmodium DNA

December 1, 2015 - 18:14 -- Open Access
Author(s): 
Michael Cordray, Rebecca Richards-Kortum
Reference: 
Malaria Journal 2015, 14:472 (26 November 2015)

The device was capable of carrying out the RPA reaction and detecting meaningful amounts of synthetic Plasmodium DNA in a self-sealing and self-contained device.

NOT Open Access | Two independently folding units of Plasmodium profilin suggest evolution via gene fusion

October 20, 2015 - 07:28 -- NOT Open Access
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Author(s): 
Saligram Prabhakar Bhargav, Juha Vahokoski, Juha Pekka Kallio, Andrew E. Torda, Petri Kursula & Inari Kursula
Reference: 
Cellular and Molecular Life Sciences, November 2015, Volume 72, Issue 21, pp 4193-4203

Gene fusion is a common mechanism of protein evolution that has mainly been discussed in the context of multidomain or symmetric proteins.

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

October 5, 2015 - 16:49 -- Open Access
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Author(s): 
Jessica H. Chertow, Matthew S. Alkaitis, Hans Ackerman, et al.
Reference: 
PLoS Pathog 11(9): e1005119

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection.

IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells

July 15, 2015 - 10:11 -- Open Access
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Author(s): 
Stephanie M. Coomes, Victoria S. Pelly, Mark S. Wilson, et al.
Reference: 
PLoS Pathog 11(7): e1004994

Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas.

NOT Open Access | Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae

July 1, 2015 - 15:44 -- NOT Open Access
Author(s): 
Ryan C. Smith, Carolina Barillas-Mury, and Marcelo Jacobs-Lorena
Reference: 
PNAS June 30, 2015 vol. 112 no. 26 E3412-E3420

Plasmodium parasites must complete development in the mosquito vector for transmission to occur.

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