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Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions

February 18, 2015 - 13:00 -- Open Access
Dari F. Da, Thomas S. Churcher, Rakiswendé S. Yerbanga, Bienvenue Yaméogo, Ibrahim Sangaré, Jean Bosco Ouedraogo, Robert E. Sinden, Andrew M. Blagborough, Anna Cohuet
Experimental Parasitology Volume 149, February 2015, Pages 74–83

The evaluation of transmission reducing interventions (TRI) to control malaria widely uses membrane feeding assays.

Plasmodium alveolins possess distinct but structurally and functionally related multi-repeat domains

January 28, 2015 - 16:15 -- Open Access
Fatimah S. Al-Khattaf , Annie Z. Tremp & Johannes T. Dessens
Parasitology Research February 2015, Volume 114, Issue 2, pp 631-639

The invasive and motile life stages of malaria parasites (merozoite, ookinete and sporozoite) possess a distinctive cortical structure termed the pellicle.

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

December 22, 2014 - 09:46 -- Open Access
María Belén Jiménez-Díaz, Daniel Ebert, R. Kiplin Guy, et al.
PNAS December 16, 2014 vol. 111 no. 50 E5455-E5462

Drug discovery for malaria has been transformed in the last 5 years by the discovery of many new lead compounds identified by phenotypic screening.

The Repeat Region of the Circumsporozoite Protein is Critical for Sporozoite Formation and Maturation in Plasmodium

December 18, 2014 - 06:16 -- Open Access
David J. P. Ferguson, Amanda E. Balaban, Eva-Maria Patzewitz, Richard J. Wall, Christine S. Hopp, Benoit Poulin, Asif Mohmmed, Pawan Malhotra, Alida Coppi, Photini Sinnis, Rita Tewari
PLoS ONE 9(12): e113923

The circumsporozoite protein (CSP) is the major surface protein of the sporozoite stage of malaria parasites and has multiple functions as the parasite develops and then migrates from the mosquito midgut to the mammalian liver.

Future Climate Data from RCP 4.5 and Occurrence of Malaria in Korea

October 15, 2014 - 19:04 -- Open Access
Janwon Kwak, Huiseong Noh, Soojun Kim, Vijay P. Singh, Seung Jin Hong, Duckgil Kim, Keonhaeng Lee, Narae Kang and Hung Soo Kim
Int. J. Environ. Res. Public Health 2014, 11(10), 10587-10605

The objective of this study is to quantify the effect of climatic factors on the occurrence of malaria in Korea and construct a malaria occurrence model for predicting the future trend of malaria under the influence of climate change.


Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial

September 29, 2014 - 16:39 -- Open Access
Raquel González , Ghyslain Mombo-Ngoma, Clara Menéndez, et al.
PLoS Med 11(9): e1001733

The study arms were: (1) SP, (2) single dose MQ (15 mg/kg), and (3) split-dose MQ in the context of long lasting insecticide treated nets. There was no difference on low birth weight prevalence (primary study outcome) between groups (360/2,778 [13.0%]) for MQ group and 177/1,398 (12.7%) for SP group; risk ratio [RR], 1.02 (95% CI 0.86–1.22; p = 0.80 in the ITT analysis).

Impairment of executive function in Kenyan children exposed to severe falciparum malaria with neurological involvement

September 25, 2014 - 12:43 -- Open Access
Kariuki SM, Abubakar A, Newton CR, Kihara M
Malaria Journal 2014, 13 :365 (16 September 2014)

Linear regression was used to determine the association between neurological phenotypes of severe malaria and executive function performance scores, accounting for potential confounders.


Development of a transmission-blocking malaria vaccine: Progress, challenges, and the path forward

September 23, 2014 - 16:58 -- Open Access
Julia K. Nunes, Colleen Woods, Terrell Carter, Theresa Raphael, Merribeth J. Morin, Diadier Diallo, Didier Leboulleux, Sanjay Jain, Christian Loucq, David C. Kaslow, Ashley J. Birkett
Vaccine, Volume 32, Issue 43, 29 September 2014, Pages 5531-5539

This article describes the progress made in critical areas since 2010, highlights key challenges that remain, and outlines important next steps to maximize the potential for SSM-VIMTs to contribute to the broader malaria elimination and eradication objectives.

Not Open Access | Description, molecular characterization, and patterns of distribution of a widespread New World avian malaria parasite (Haemosporida: Plasmodiidae), Plasmodium (Novyella) homopolare sp. nov.

September 4, 2014 - 12:05 -- NOT Open Access
Erika L. Walther , Gediminas Valkiūnas , Angie D. González , Nubia E. Matta , Robert E. Ricklefs , Anthony Cornel & Ravinder N. M. Sehgal
Parasitology Research September 2014, Volume 113, Issue 9, pp 3319-3332

Plasmodium (Novyella) homopolare, a newly described Plasmodium species, was found in a wide range of Passeriformes species in California, USA, and Colombia.

New Insight into the Mechanism of Accumulation and Intraerythrocytic Compartmentation of Albitiazolium, a New Type of Antimalarial

August 19, 2014 - 14:09 -- Open Access
Sharon Wein, Christophe Tran Van Ba, Marjorie Maynadier, Yann Bordat, Julie Perez, Suzanne Peyrottes, Laurent Fraisse, and Henri J. Vial
Antimicrob. Agents Chemother. September 2014 vol. 58 no. 9 5519-5527

Bis-thiazolium salts constitute a new class of antihematozoan drugs that inhibit parasite phosphatidylcholine biosynthesis.

Medical Treatment: 


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