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Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

August 26, 2016 - 18:15 -- Open Access
Akshay T. Krishnamurty, Christopher D. Thouvenel, Silvia Portugal, Gladys J. Keitany, Karen S. Kim, Anthony Holder, Peter D. Crompton, David J. Rawlings, Marion Pepper
Immunity, Volume 45, Issue 2, 16 August 2016, Pages 402–414

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBC).

NOT Open Access | Bistacrine derivatives as new potent antimalarials

July 23, 2016 - 17:59 -- NOT Open Access
Ines Schmidt, Gabriele Pradel, Ludmilla Sologub, Alexandra Golzmann, Che J. Ngwa, Anna Kucharski, Tanja Schirmeister, Ulrike Holzgrabe
Bioorganic & Medicinal Chemistry, Volume 24, Issue 16, 15 August 2016, Pages 3636–3642

Linking two tacrine molecules results in a tremendous increase of activity against Plasmodia in comparison to the monomer.

Medical Treatment: 

NOT Open Access | Dendritic cell function and antigen presentation in malaria

May 31, 2016 - 17:29 -- NOT Open Access
Ian A Cockburn, Fidel Zavala
Current Opinion in Immunology Volume 40, June 2016, Pages 1–6

Due to the diverse roles T cells play in protection against malaria as well as pathogenesis it is critical to know which cells present antigen and the nature of the antigens they present.

Detection of Plasmodium using filter paper and nested PCR for patients with malaria in Sanliurfa, in Turkey

May 31, 2016 - 17:26 -- Open Access
Nebiye Yentur Doni, Fadile Yildiz Zeyrek and Adnan Seyrek
Malaria Journal 2016 15:299, 28 May 2016

This study revealed that the accurate diagnosis of malaria by nPCR was compulsory in malaria-endemic Sanliurfa and nPCR should be applied routinely in laboratory studies.


ARAM: an automated image analysis software to determine rosetting parameters and parasitaemia in Plasmodium samples

April 19, 2016 - 17:31 -- Open Access
Patrick Wolfgang Kudella, Kirsten Moll, Mats Wahlgren, Achim Wixforth and Christoph Westerhausen
Malaria Journal 2016 15:223, 18 April 2016

Automated rosetting analyzer for micrographs has the capability to push malaria research to a more quantitative and statistically significant level with increased reliability due to operator independence.

NOT Open Access | Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

April 12, 2016 - 17:01 -- NOT Open Access
Michelle Gazdik, Kate E. Jarman, Brad E. Sleebs, et al.
Bioorganic & Medicinal Chemistry Volume 24, Issue 9, 1 May 2016, Pages 1993–2010

The use of arginine isosteres is a known strategy to overcome poor membrane permeability commonly associated with peptides or peptidomimetics that possess this highly polar amino acid.

Low prevalence of Plasmodium and absence of malaria transmission in Conakry, Guinea: prospects for elimination

March 19, 2016 - 19:40 -- Open Access
Bernard L. Kouassi, Dziedzom K. de Souza, Benjamin G. Koudou, et al.
Malaria Journal 2016 15:175, 18 March 2016

The low density of larval and adult stages of Anopheles mosquitoes, the absence of infected An. gambiae species and the low prevalence of Plasmodium in under 5-year-old children are important features that might facilitate malaria elimination in Conakry.

Human malaria diagnosis using a single-step direct-PCR based on the Plasmodium cytochrome oxidase III gene

March 1, 2016 - 18:06 -- Open Access
Diego F. Echeverry, Nicholas A. Deason, Neil F. Lobo, et al.
Malaria Journal 2016 15:128, 29 February 2016

The COX-III single direct PCR is an alternative method for accurate detection of Plasmodium microscopic and submicroscopic infections in humans, especially when a large number of samples require screening.

NOT Open Access | Structure- and function-based design of Plasmodium-selective proteasome inhibitors

February 15, 2016 - 18:17 -- NOT Open Access
Hao Li, Anthony J. O’Donoghue, Matthew Bogyo, et al.
Nature 530, 233–236 (11 February 2016)

The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation.

Consistent prevalence of asymptomatic infections in malaria endemic populations in Colombia over time

February 9, 2016 - 16:55 -- Open Access
Juan M. Vásquez-Jiménez, Myriam Arévalo-Herrera, Juliana Henao-Giraldo, Karen Molina-Gómez, María Arce-Plata, Andrés F. Vallejo and Sócrates Herrera
Malaria Journal 2016 15:70, 6 February 2016

This study demonstrates an important prevalence of asymptomatic malaria cases not detectable by microscopy, which therefore remain untreated representing a parasite pool for malaria transmission.


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