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plasmodium

ARAM: an automated image analysis software to determine rosetting parameters and parasitaemia in Plasmodium samples

April 19, 2016 - 17:31 -- Open Access
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Author(s): 
Patrick Wolfgang Kudella, Kirsten Moll, Mats Wahlgren, Achim Wixforth and Christoph Westerhausen
Reference: 
Malaria Journal 2016 15:223, 18 April 2016

Automated rosetting analyzer for micrographs has the capability to push malaria research to a more quantitative and statistically significant level with increased reliability due to operator independence.

NOT Open Access | Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

April 12, 2016 - 17:01 -- NOT Open Access
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Author(s): 
Michelle Gazdik, Kate E. Jarman, Brad E. Sleebs, et al.
Reference: 
Bioorganic & Medicinal Chemistry Volume 24, Issue 9, 1 May 2016, Pages 1993–2010

The use of arginine isosteres is a known strategy to overcome poor membrane permeability commonly associated with peptides or peptidomimetics that possess this highly polar amino acid.

Low prevalence of Plasmodium and absence of malaria transmission in Conakry, Guinea: prospects for elimination

March 19, 2016 - 19:40 -- Open Access
Author(s): 
Bernard L. Kouassi, Dziedzom K. de Souza, Benjamin G. Koudou, et al.
Reference: 
Malaria Journal 2016 15:175, 18 March 2016

The low density of larval and adult stages of Anopheles mosquitoes, the absence of infected An. gambiae species and the low prevalence of Plasmodium in under 5-year-old children are important features that might facilitate malaria elimination in Conakry.

Human malaria diagnosis using a single-step direct-PCR based on the Plasmodium cytochrome oxidase III gene

March 1, 2016 - 18:06 -- Open Access
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Author(s): 
Diego F. Echeverry, Nicholas A. Deason, Neil F. Lobo, et al.
Reference: 
Malaria Journal 2016 15:128, 29 February 2016

The COX-III single direct PCR is an alternative method for accurate detection of Plasmodium microscopic and submicroscopic infections in humans, especially when a large number of samples require screening.

NOT Open Access | Structure- and function-based design of Plasmodium-selective proteasome inhibitors

February 15, 2016 - 18:17 -- NOT Open Access
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Author(s): 
Hao Li, Anthony J. O’Donoghue, Matthew Bogyo, et al.
Reference: 
Nature 530, 233–236 (11 February 2016)

The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation.

Consistent prevalence of asymptomatic infections in malaria endemic populations in Colombia over time

February 9, 2016 - 16:55 -- Open Access
Author(s): 
Juan M. Vásquez-Jiménez, Myriam Arévalo-Herrera, Juliana Henao-Giraldo, Karen Molina-Gómez, María Arce-Plata, Andrés F. Vallejo and Sócrates Herrera
Reference: 
Malaria Journal 2016 15:70, 6 February 2016

This study demonstrates an important prevalence of asymptomatic malaria cases not detectable by microscopy, which therefore remain untreated representing a parasite pool for malaria transmission.

Malaria and blood transfusion: major issues of blood safety in malaria-endemic countries and strategies for mitigating the risk of Plasmodium parasites

January 26, 2016 - 18:54 -- Open Access
Author(s): 
Saleh Abdullah & Kaliyaperumal Karunamoorthi
Reference: 
Parasitology Research, Volume 115, Issue 1 , pp 35-47

Malaria inflicts humankind over centuries, and it remains as a major threat to both clinical medicine and public health worldwide.

UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages

January 20, 2016 - 15:30 -- Open Access
Author(s): 
Min Zhang, Satish Mishra, Ramanavelan Sakthivel, Beatriz M. A. Fontoura, Victor Nussenzweig
Reference: 
PLoS Pathog 12(1): e1005370

Plasmodium salivary sporozoites are the infectious form of the malaria parasite and are dormant inside salivary glands of Anopheles mosquitoes.

A paper and plastic device for the combined isothermal amplification and lateral flow detection of Plasmodium DNA

December 1, 2015 - 18:14 -- Open Access
Author(s): 
Michael Cordray, Rebecca Richards-Kortum
Reference: 
Malaria Journal 2015, 14:472 (26 November 2015)

The device was capable of carrying out the RPA reaction and detecting meaningful amounts of synthetic Plasmodium DNA in a self-sealing and self-contained device.

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