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NOT Open Access | The role of antioxidants treatment on the pathogenesis of malarial infections: a review

March 7, 2014 - 10:50 -- NOT Open Access
Murtala Bindawa Isah & Mohammed Auwal Ibrahim
Parasitology Research, March 2014, Volume 113, Issue 3, pp 801-809

Oxidative damage is one of the most important pathological consequences of malarial infections.

Medical Treatment: 

First case of a naturally acquired human infection with Plasmodium cynomolgi

March 7, 2014 - 07:50 -- Open Access
Ta TH, Hisam S, Lanza M, Jiram AI, Ismail N, Rubio JM
Malaria Journal 2014, 13 :68 (24 February 2014)

Since 1960, a total of seven species of monkey malaria have been reported as transmissible to man by mosquito bite:

Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review

February 19, 2014 - 21:09 -- Ingeborg van Schayk
J. Church and K. Maitland
BMC Medicine 2014, 12:31

Severe malaria remains a major cause of pediatric hospital admission across Africa. Invasive bacterial infection (IBI) is a recognized complication of Plasmodium falciparum malaria, resulting in a substantially worse outcome. Whether a biological relationship exists between malaria infection and IBI susceptibility remains unclear. We, therefore, examined the extent, nature and evidence of this association.

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

February 5, 2014 - 02:21 -- Open Access
Marco A. Ataide, Warrison A. Andrade, Ricardo T. Gazzinelli, et al.
PLoS Pathog 10(1): e1003885

In this report, we describe a signature for the expression of inflammasome-related genes and caspase-1 activation in malaria. Indeed, when we infected mice, Plasmodium infection was sufficient to promote MyD88-mediated caspase-1 activation, dependent on IFN-γ-priming and the expression of inflammasome components ASC, P2X7R, NLRP3 and/or NLRP12

Evolution of Chloroplast Transcript Processing in Plasmodium and Its Chromerid Algal Relatives

January 22, 2014 - 14:58 -- Open Access
Richard G. Dorrell, James Drew, R. Ellen R. Nisbet, Christopher J. Howe
PLoS Genet 10(1): e1004008

We additionally present evidence that poly(U) tail addition in chromerids is involved in the alternative processing of polycistronic precursors covering multiple photosynthesis genes, and appears to be associated with high levels of transcript abundance.

Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites

January 20, 2014 - 18:18 -- Open Access
Zhou D, Zhang D, Zhu C,et al.
BMC Genomics 2014, 15 :42 (18 January 2014)

The A. sinensis genome produced in this study, provides an important resource for analyzing the genetic basis of susceptibility and resistance of mosquitoes to Plasmodium parasites research which will ultimately facilitate the design of urgently needed interventions against this debilitating mosquito-borne disease.

Not Open Access | Plasmodium Products Contribute to Severe Malarial Anemia by Inhibiting Erythropoietin-Induced Proliferation of Erythroid Precursors

December 17, 2013 - 19:13 -- NOT Open Access
Neeta Thawani, Mifong Tam, Marie-Josée Bellemare, D. Scott Bohle, Martin Olivier, J. Brian de Souza and Mary M. Stevenson
J Infect Dis. (2014) 209 (1): 140-149

To determine whether Hz contributes to malarial anemia, P. yoelii–derived or synthetic Hz was administered to naive mice, and the development of anemia, reticulocytosis, and RBC turnover was determined.

A case report of transfusion-transmitted Plasmodium malariae from an asymptomatic non-immune traveller

December 11, 2013 - 08:35 -- Open Access
Brouwer EE, van Hellemond JJ, van Genderen PJ, Slot E, van Lieshout L, Visser LG, Wismans PJ
Malaria Journal 2013, 12 :439 (5 December 2013)


The incidence of transfusion-transmitted malaria is very low in non-endemic countries due to strict donor selection. The optimal strategy to mitigate the risk of transfusion-transmitted malaria in non-endemic countries without unnecessary exclusion of blood donations is, however, still debated and asymptomatic carriers of Plasmodium species may still be qualified to donate blood for transfusion purposes.

Review | Escaping the immune system: How the malaria parasite makes vaccine development a challenge

December 4, 2013 - 16:48 -- Open Access
Danielle I. Stanisic, Alyssa E. Barry, Michael F. Good
Trends in Parasitology, Volume 29, Issue 12, December 2013, Pages 612-622

With data from Phase III trials indicating that the leading malaria vaccine candidate, RTS,S, has limited efficacy, it is necessary to reconsider approaches to the development of a vaccine capable of inducing long-lived protection.

Not Open Access | Imaging of the spleen in malaria

November 28, 2013 - 13:51 -- NOT Open Access
Mireia Ferrer, Lorena Martin-Jaular, Mariana De Niz, Shahid M. Khan, Chris J. Janse, Maria Calvo, Volker Heussler, Hernando A. del Portillo
Parasitology International, Volume 63, Issue 1, February 2014, Pages 195-205

Here, we review imaging techniques used for studying the malarious spleen, from optical microscopy to in vivo imaging, and discuss the bright perspectives of evolving technologies in our present understanding of the role of this organ in infections caused by Plasmodium.


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