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NOT Open Access | Dynamics of clonal diversity in natural infections of the malaria parasite Plasmodium mexicanum in its free-ranging lizard host

June 24, 2014 - 07:06 -- NOT Open Access
Nathan D. Hicks & Jos J. Schall
Parasitology Research, June 2014, Volume 113, Issue 6, pp 2059-2067

Within mixed-genotype infections of malaria parasites (Plasmodium), the number of genetic clones present is associated with variation in important life history traits of the infection, including virulence. Within mixed-genotype infections of malaria parasites (Plasmodium), the number of genetic clones present is associated with variation in important life history traits of the infection, including virulence. Although the number of clones present is important, how the proportion of those clones varies over time is poorly known.

Infection and Co-infection with Helminths and Plasmodium among School Children in Côte d’Ivoire: Results from a National Cross-Sectional Survey

June 10, 2014 - 15:09 -- Open Access
Richard B. Yapi, Eveline Hürlimann, Giovanna Raso, et al.
PLoS Negl Trop Dis 8(6): e2913

More than 60% of the school children surveyed were infected with Plasmodium across Côte d’Ivoire, and about one out of six had a helminth-Plasmodium co-infection.

PCR targeting Plasmodium mitochondrial genome of DNA extracted from dried blood on filter paper compared to whole blood

April 16, 2014 - 18:59 -- Open Access
Strøm GE, Moyo S, Fataki M, Langeland N, Blomberg B
Malaria Journal 2014, 13 :137 (7 April 2014)

In this study, PCR for malaria mitochondrial DNA extracted from whole blood was more sensitive than from DBS. However, DBS are a practical alternative to whole blood and detected approximately the same number of cases as RDTs and, therefore, remain relevant for research purposes.

NOT Open Access| Signatures of malaria vaccine efficacy in ageing murine immune memory

April 10, 2014 - 07:17 -- NOT Open Access
J. M. Haussig, J. Burgold, J. C. R. Hafalla, K. Matuschewski and T. W. A. Kooij
Parasite Immunology Volume 36, Issue 5, pages 199–206, May 2014

Malaria transmission occurs by mosquito bite. Thereafter, Plasmodium sporozoites specifically invade the liver, where they develop into thousands of merozoites that initiate blood-stage infection and clinical malaria.

Evaluating local vegetation cover as a risk factor for malaria transmission: a new analytical approach using ImageJ

April 8, 2014 - 20:11 -- Open Access
Ricotta EE, Frese SA, Choobwe C, Louis TA, Shiff CJ
Malaria Journal 2014, 13 :94 (13 March 2014)

Analysis of this vegetation can be done using satellite information and mapping programs, such as Google Earth, but manual quantification is difficult and can be tedious and subjective. A more objective method is required.

A flow cytometric assay to quantify invasion of red blood cells by rodent Plasmodium parasites in vivo

April 7, 2014 - 17:17 -- Open Access
Lelliott PM, Lampkin S, McMorran BJ, Foote SJ, Burgio G
Malaria Journal 2014, 13 :100 (17 March 2014)

Assays for analysing parasite invasion in vitro have been developed, but no equivalent assays exist for in vivo studies. This article describes a novel flow cytometric in vivo parasite invasion assay.

Were medicine quality and pharmaceutical management contributing factors in diminishing artemisinin efficacy in Guyana and Suriname?

April 7, 2014 - 16:49 -- Open Access
Pribluda VS, Evans L, Barillas E, Marmion J, Lukulay P, Chang J
Malaria Journal 2014, 13 :77 (3 March 2014)

Data on malaria medicine quality and pharmaceutical management, generated in the context of the Amazon Malaria Initiative (AMI), was reviewed and discussed.

Mixed-species Plasmodium falciparum and Plasmodium ovale malaria in a paediatric returned traveller

April 4, 2014 - 18:31 -- Open Access
Senn H, Alattas N, Boggild AK, Morris SK
Malaria Journal 2014, 13 :78 (5 March 2014)

The epidemiology of mixed infections, likely pathophysiology of his presentation, and the implications for malaria testing and treatment in returned travellers are discussed.

Not Open Access | To kill or not to kill, that is the question: cytocidal antimalarial drug resistance

March 24, 2014 - 18:43 -- NOT Open Access
Paul D. Roepe
Trends in Parasitology, Volume 30, Issue 3, March 2014, Pages 130-135

These conclusions have important implications for elucidating other drug resistance phenomena and emphasize new concepts that are essential for the development of new drug therapy.

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

March 11, 2014 - 13:43 -- Open Access
Mathieu Brochet, Mark O. Collins, Oliver Billker, et al.
PLoS Biol 12(3): e1001806

Many critical events in the Plasmodium life cycle rely on the controlled release of Ca2+ from intracellular stores to activate stage-specific Ca2+-dependent protein kinases.


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