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plasmodium

Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial

September 29, 2014 - 16:39 -- Open Access
Author(s): 
Raquel González , Ghyslain Mombo-Ngoma, Clara Menéndez, et al.
Reference: 
PLoS Med 11(9): e1001733

The study arms were: (1) SP, (2) single dose MQ (15 mg/kg), and (3) split-dose MQ in the context of long lasting insecticide treated nets. There was no difference on low birth weight prevalence (primary study outcome) between groups (360/2,778 [13.0%]) for MQ group and 177/1,398 (12.7%) for SP group; risk ratio [RR], 1.02 (95% CI 0.86–1.22; p = 0.80 in the ITT analysis).

Impairment of executive function in Kenyan children exposed to severe falciparum malaria with neurological involvement

September 25, 2014 - 12:43 -- Open Access
Author(s): 
Kariuki SM, Abubakar A, Newton CR, Kihara M
Reference: 
Malaria Journal 2014, 13 :365 (16 September 2014)

Linear regression was used to determine the association between neurological phenotypes of severe malaria and executive function performance scores, accounting for potential confounders.

Country: 

Development of a transmission-blocking malaria vaccine: Progress, challenges, and the path forward

September 23, 2014 - 16:58 -- Open Access
Author(s): 
Julia K. Nunes, Colleen Woods, Terrell Carter, Theresa Raphael, Merribeth J. Morin, Diadier Diallo, Didier Leboulleux, Sanjay Jain, Christian Loucq, David C. Kaslow, Ashley J. Birkett
Reference: 
Vaccine, Volume 32, Issue 43, 29 September 2014, Pages 5531-5539

This article describes the progress made in critical areas since 2010, highlights key challenges that remain, and outlines important next steps to maximize the potential for SSM-VIMTs to contribute to the broader malaria elimination and eradication objectives.

Not Open Access | Description, molecular characterization, and patterns of distribution of a widespread New World avian malaria parasite (Haemosporida: Plasmodiidae), Plasmodium (Novyella) homopolare sp. nov.

September 4, 2014 - 12:05 -- NOT Open Access
Tags: 
Author(s): 
Erika L. Walther , Gediminas Valkiūnas , Angie D. González , Nubia E. Matta , Robert E. Ricklefs , Anthony Cornel & Ravinder N. M. Sehgal
Reference: 
Parasitology Research September 2014, Volume 113, Issue 9, pp 3319-3332

Plasmodium (Novyella) homopolare, a newly described Plasmodium species, was found in a wide range of Passeriformes species in California, USA, and Colombia.

New Insight into the Mechanism of Accumulation and Intraerythrocytic Compartmentation of Albitiazolium, a New Type of Antimalarial

August 19, 2014 - 14:09 -- Open Access
Author(s): 
Sharon Wein, Christophe Tran Van Ba, Marjorie Maynadier, Yann Bordat, Julie Perez, Suzanne Peyrottes, Laurent Fraisse, and Henri J. Vial
Reference: 
Antimicrob. Agents Chemother. September 2014 vol. 58 no. 9 5519-5527

Bis-thiazolium salts constitute a new class of antihematozoan drugs that inhibit parasite phosphatidylcholine biosynthesis.

Medical Treatment: 

Maladjusted Host Immune Responses Induce Experimental Cerebral Malaria-Like Pathology in a Murine Borrelia and Plasmodium Co-Infection Model

August 19, 2014 - 14:07 -- Open Access
Author(s): 
Johan Normark, Maria Nelson, Patrik Engström, Marie Andersson, Rafael Björk, Thomas Moritz, Anna Fahlgren, Sven Bergström
Reference: 
PLoS ONE 9(7): e103295

In the Plasmodium infected host, a balance between pro- and anti-inflammatory responses is required to clear the parasites without inducing major host pathology.

Effect of deworming on school-aged children's physical fitness, cognition and clinical parameters in a malaria-helminth co-endemic area of Cote d'Ivoire

July 30, 2014 - 17:08 -- Open Access
Author(s): 
Hürlimann E, Houngbedji CA, N'Dri PB, Bänninger D, Coulibaly JT, Yap P, Silué KD, N'Goran EK, Raso G, Utzinger J
Reference: 
BMC Infectious Diseases 2014, 14 :411 (25 July 2014)

This study revealed conflicting results regarding clinical parameters and cognitive behaviour of children after two rounds of deworming.

NOT Open Access | Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium

July 30, 2014 - 06:39 -- NOT Open Access
Author(s): 
James T. Njuguna, Imke von Koschitzky, Heike Gerhardt, Michael Lämmerhofer, Ali Choucry, Mario Pink, Simone Schmitz-Spahnke, Mohammed A. Bakheit, Christina Strube, Annette Kaiser
Reference: 
Bioorganic & Medicinal Chemistry, Volume 22, Issue 15, 1 August 2014, Pages 4338–4346

East Coast fever (ECF) is a tick-borne disease caused by the parasite Theileria parva which infects cattle.

NOT Open Access | Local Immune Response to Injection of Plasmodium Sporozoites into the Skin

July 22, 2014 - 09:37 -- NOT Open Access
Author(s): 
Laura Mac-Daniel, Matthew R. Buckwalter, Michèle Berthet, Yasemin Virk, Katsuyuki Yui, Matthew L. Albert, Pascale Gueirard, and Robert Ménard
Reference: 
The Journal of Immunology August 1, 2014 vol. 193 no. 3 1246-1257

Malarial infection is initiated when the sporozoite form of the Plasmodium parasite is inoculated into the skin by a mosquito.

Medical Condition: 

The ears of the African elephant: unexpected high seroprevalence of Plasmodium ovale and Plasmodium malariae in healthy populations in Western Africa

July 3, 2014 - 11:14 -- Open Access
Author(s): 
Doderer-Lang C, Atchade PS, Meckert L, Haar E, Perrotey S, Filisetti D, Aboubacar A, Pfaff AW, Brunet J, Chabi NW, Akpovi CD, Anani L, Bigot A, Sanni A, Candolfi E
Reference: 
Malaria Journal 2014, 13 :240 (18 June 2014)

A High Rate Of Antibodies Against P. Ovale And P. Malariae Was Found In Asymptomatic Blood Donors.

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