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Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial

September 29, 2014 - 16:39 -- Open Access
Raquel González , Ghyslain Mombo-Ngoma, Clara Menéndez, et al.
PLoS Med 11(9): e1001733

The study arms were: (1) SP, (2) single dose MQ (15 mg/kg), and (3) split-dose MQ in the context of long lasting insecticide treated nets. There was no difference on low birth weight prevalence (primary study outcome) between groups (360/2,778 [13.0%]) for MQ group and 177/1,398 (12.7%) for SP group; risk ratio [RR], 1.02 (95% CI 0.86–1.22; p = 0.80 in the ITT analysis).

Impairment of executive function in Kenyan children exposed to severe falciparum malaria with neurological involvement

September 25, 2014 - 12:43 -- Open Access
Kariuki SM, Abubakar A, Newton CR, Kihara M
Malaria Journal 2014, 13 :365 (16 September 2014)

Linear regression was used to determine the association between neurological phenotypes of severe malaria and executive function performance scores, accounting for potential confounders.


Development of a transmission-blocking malaria vaccine: Progress, challenges, and the path forward

September 23, 2014 - 16:58 -- Open Access
Julia K. Nunes, Colleen Woods, Terrell Carter, Theresa Raphael, Merribeth J. Morin, Diadier Diallo, Didier Leboulleux, Sanjay Jain, Christian Loucq, David C. Kaslow, Ashley J. Birkett
Vaccine, Volume 32, Issue 43, 29 September 2014, Pages 5531-5539

This article describes the progress made in critical areas since 2010, highlights key challenges that remain, and outlines important next steps to maximize the potential for SSM-VIMTs to contribute to the broader malaria elimination and eradication objectives.

Not Open Access | Description, molecular characterization, and patterns of distribution of a widespread New World avian malaria parasite (Haemosporida: Plasmodiidae), Plasmodium (Novyella) homopolare sp. nov.

September 4, 2014 - 12:05 -- NOT Open Access
Erika L. Walther , Gediminas Valkiūnas , Angie D. González , Nubia E. Matta , Robert E. Ricklefs , Anthony Cornel & Ravinder N. M. Sehgal
Parasitology Research September 2014, Volume 113, Issue 9, pp 3319-3332

Plasmodium (Novyella) homopolare, a newly described Plasmodium species, was found in a wide range of Passeriformes species in California, USA, and Colombia.

New Insight into the Mechanism of Accumulation and Intraerythrocytic Compartmentation of Albitiazolium, a New Type of Antimalarial

August 19, 2014 - 14:09 -- Open Access
Sharon Wein, Christophe Tran Van Ba, Marjorie Maynadier, Yann Bordat, Julie Perez, Suzanne Peyrottes, Laurent Fraisse, and Henri J. Vial
Antimicrob. Agents Chemother. September 2014 vol. 58 no. 9 5519-5527

Bis-thiazolium salts constitute a new class of antihematozoan drugs that inhibit parasite phosphatidylcholine biosynthesis.

Medical Treatment: 

Maladjusted Host Immune Responses Induce Experimental Cerebral Malaria-Like Pathology in a Murine Borrelia and Plasmodium Co-Infection Model

August 19, 2014 - 14:07 -- Open Access
Johan Normark, Maria Nelson, Patrik Engström, Marie Andersson, Rafael Björk, Thomas Moritz, Anna Fahlgren, Sven Bergström
PLoS ONE 9(7): e103295

In the Plasmodium infected host, a balance between pro- and anti-inflammatory responses is required to clear the parasites without inducing major host pathology.

Effect of deworming on school-aged children's physical fitness, cognition and clinical parameters in a malaria-helminth co-endemic area of Cote d'Ivoire

July 30, 2014 - 17:08 -- Open Access
Hürlimann E, Houngbedji CA, N'Dri PB, Bänninger D, Coulibaly JT, Yap P, Silué KD, N'Goran EK, Raso G, Utzinger J
BMC Infectious Diseases 2014, 14 :411 (25 July 2014)

This study revealed conflicting results regarding clinical parameters and cognitive behaviour of children after two rounds of deworming.

NOT Open Access | Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium

July 30, 2014 - 06:39 -- NOT Open Access
James T. Njuguna, Imke von Koschitzky, Heike Gerhardt, Michael Lämmerhofer, Ali Choucry, Mario Pink, Simone Schmitz-Spahnke, Mohammed A. Bakheit, Christina Strube, Annette Kaiser
Bioorganic & Medicinal Chemistry, Volume 22, Issue 15, 1 August 2014, Pages 4338–4346

East Coast fever (ECF) is a tick-borne disease caused by the parasite Theileria parva which infects cattle.

NOT Open Access | Local Immune Response to Injection of Plasmodium Sporozoites into the Skin

July 22, 2014 - 09:37 -- NOT Open Access
Laura Mac-Daniel, Matthew R. Buckwalter, Michèle Berthet, Yasemin Virk, Katsuyuki Yui, Matthew L. Albert, Pascale Gueirard, and Robert Ménard
The Journal of Immunology August 1, 2014 vol. 193 no. 3 1246-1257

Malarial infection is initiated when the sporozoite form of the Plasmodium parasite is inoculated into the skin by a mosquito.

Medical Condition: 

The ears of the African elephant: unexpected high seroprevalence of Plasmodium ovale and Plasmodium malariae in healthy populations in Western Africa

July 3, 2014 - 11:14 -- Open Access
Doderer-Lang C, Atchade PS, Meckert L, Haar E, Perrotey S, Filisetti D, Aboubacar A, Pfaff AW, Brunet J, Chabi NW, Akpovi CD, Anani L, Bigot A, Sanni A, Candolfi E
Malaria Journal 2014, 13 :240 (18 June 2014)

A High Rate Of Antibodies Against P. Ovale And P. Malariae Was Found In Asymptomatic Blood Donors.


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