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Not Open Access | A Simple Real-Time PCR and Amplicon Sequencing Method for Identification of Plasmodium Species in Human Whole Blood

May 20, 2015 - 15:12 -- NOT Open Access
Lefterova MI, Budvytiene I, Sandlund J, Färnert A, Banaei N
J Clin Microbiol. 2015 May 13. pii: JCM.00542-15.

Here we describe a SYBR Green-based real-time PCR assay for Plasmodium species identification from whole blood, which uses a panel of reactions to detect species-specific non-18S rRNA gene targets.

Not Open Access | Disruption of parasite hmgb2 gene attenuates Plasmodium berghei ANKA pathogenicity

April 28, 2015 - 16:47 -- NOT Open Access
Sylvie Briquet, Nadou Lawson-Hogban, Bertrand Boisson, Miguel P. Soares, Roger Péronet, Leanna Smith, Robert Ménard, Michel Huerre, Salah Mécheri, and Catherine Vaquero
Infect. Immun. 27 April 2015

We found that the Plasmodium genome encodes two genuine HMGB factors, Plasmodium HMGB1 and HMGB2 that encompass, as their human counterparts, a pro-inflammatory domain.

Hybridization and pre-zygotic reproductive barriers in Plasmodium

April 11, 2015 - 11:40 -- Open Access
Ramiro RS, Khan SM, Franke-Fayard B, Janse CJ, Obbard DJ, Reece SE
Proc Biol Sci. 2015 May 7;282(1806)

We use the rodent malaria parasites P. berghei and P. yoelii to investigate the ecology of mixed-species mating groups, identify proteins involved in pre-zygotic barriers, and examine their evolution.

Distribution and Risk Factors for Plasmodium and Helminth Co-infections: A Cross-Sectional Survey among Children in Bagamoyo District, Coastal Region of Tanzania

April 3, 2015 - 09:57 -- Open Access
Nahya Salim, Stefanie Knopp, Blaise Genton, et al.
PLoS Negl Trop Dis 9(4): e0003660

The findings suggest that STH and Plasmodium infections tend to occur in the same children, with increasing prevalence of co-infection with age.


Not Open Access | Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria

March 18, 2015 - 12:37 -- NOT Open Access
Sahil Kumar, Rajesh K. Singh, Babita Patial, Sachin Goyal, T. R. Bhardwaj
Journal of Enzyme Inhibition and Medicinal Chemistry, March 16, 2015

This review presents recent modifications of 4-aminoquinoline and 8-aminoquinolone rings as leads to novel active molecules which are under clinical trials. The review also encompasses the other heterocyclic compounds emerged as potential antimalarial agents with promising results such as acridinediones and acridinone analogues, pyridines and quinolones as antimalarials.

Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions

February 18, 2015 - 13:00 -- Open Access
Dari F. Da, Thomas S. Churcher, Rakiswendé S. Yerbanga, Bienvenue Yaméogo, Ibrahim Sangaré, Jean Bosco Ouedraogo, Robert E. Sinden, Andrew M. Blagborough, Anna Cohuet
Experimental Parasitology Volume 149, February 2015, Pages 74–83

The evaluation of transmission reducing interventions (TRI) to control malaria widely uses membrane feeding assays.

Plasmodium alveolins possess distinct but structurally and functionally related multi-repeat domains

January 28, 2015 - 16:15 -- Open Access
Fatimah S. Al-Khattaf , Annie Z. Tremp & Johannes T. Dessens
Parasitology Research February 2015, Volume 114, Issue 2, pp 631-639

The invasive and motile life stages of malaria parasites (merozoite, ookinete and sporozoite) possess a distinctive cortical structure termed the pellicle.

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

December 22, 2014 - 09:46 -- Open Access
María Belén Jiménez-Díaz, Daniel Ebert, R. Kiplin Guy, et al.
PNAS December 16, 2014 vol. 111 no. 50 E5455-E5462

Drug discovery for malaria has been transformed in the last 5 years by the discovery of many new lead compounds identified by phenotypic screening.

The Repeat Region of the Circumsporozoite Protein is Critical for Sporozoite Formation and Maturation in Plasmodium

December 18, 2014 - 06:16 -- Open Access
David J. P. Ferguson, Amanda E. Balaban, Eva-Maria Patzewitz, Richard J. Wall, Christine S. Hopp, Benoit Poulin, Asif Mohmmed, Pawan Malhotra, Alida Coppi, Photini Sinnis, Rita Tewari
PLoS ONE 9(12): e113923

The circumsporozoite protein (CSP) is the major surface protein of the sporozoite stage of malaria parasites and has multiple functions as the parasite develops and then migrates from the mosquito midgut to the mammalian liver.

Future Climate Data from RCP 4.5 and Occurrence of Malaria in Korea

October 15, 2014 - 19:04 -- Open Access
Janwon Kwak, Huiseong Noh, Soojun Kim, Vijay P. Singh, Seung Jin Hong, Duckgil Kim, Keonhaeng Lee, Narae Kang and Hung Soo Kim
Int. J. Environ. Res. Public Health 2014, 11(10), 10587-10605

The objective of this study is to quantify the effect of climatic factors on the occurrence of malaria in Korea and construct a malaria occurrence model for predicting the future trend of malaria under the influence of climate change.



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