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NOT Open Access | Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior

August 23, 2017 - 16:01 -- NOT Open Access
Watcharee Amornwatcharapong, Somchart Maenpuen, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Archives of Biochemistry and Biophysics, Volume 630, 15 September 2017, Pages 91-100

Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis.

The effectiveness of non-pyrethroid insecticide-treated durable wall lining to control malaria in rural Tanzania: study protocol for a two-armed cluster randomized trial

August 15, 2017 - 16:36 -- Open Access
Mtove G, Mugasa J, Messenger L, Malima R, Mangesho P, Magogo F, Plucinski M, Hashimu R, Matowo J, Shepard D, Batengana B, Cook J, Emidi B, Halasa Y, Kaaya R, Kihombo A, Lindblade K, Makenga G, Mpangala R, Mwambuli A, Mzava R, Mziray A, Olang G, Oxborough R, Seif M, Sambu E, Samuels A, Sudi W, Thomas J, Weston S, Alilio M, Binkin N, Gimnig J, Kleinschmidt I, McElroy P, Moulton L, Norris L, Ruebush T, Venkatesan M, Rowland M, Mosha F, Kisinza W
BMC Public Health 2016, 16 :633 (25 July 2016)

This protocol describes the large-scale evaluation of a novel vector control product, designed to overcome some of the known limitations of existing methods.

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

August 15, 2017 - 16:30 -- Open Access
Drew D, Wilson D, Elliott S, Cross N, Terheggen U, Hodder A, Siba P, Chelimo K, Dent A, Kazura J, Mueller I, Beeson J
BMC Medicine 2016, 14 :144 (23 September 2016)

We found that AMA1 was a major target of naturally acquired invasion-inhibitory antibodies that were highly prevalent in malaria-endemic populations and showed a high degree of allele specificity. Significantly, the prevalence of inhibitory antibodies to different alleles varied substantially within populations and between geographic locations.

An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia

August 15, 2017 - 16:18 -- Open Access
Leang R, Khu N, Mukaka M, Debackere M, Tripura R, Kheang S, Chy S, Kak N, Buchy P, Tarantola A, Menard D, Roca-Felterer A, Fairhurst R, Kheng S, Muth S, Ngak S, Dondorp A, White N, Taylor W
BMC Medicine 2016, 14 :171 (27 October 2016)

In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. 

Life-span of in vitro differentiated Plasmodium falciparum gametocytes

August 15, 2017 - 14:37 -- Open Access
Tamirat Gebru, Albert Lalremruata, Peter G. Kremsner, Benjamin Mordmüller and Jana Held
Malaria Journal 2017 16:330, 11 August 2017

Plasmodium falciparum mature gametocytes can survive up to 16–32 days (at least 14 days for mature male gametocytes) in vitro in absence of the influence of host factors.

The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo show different binding activity level to human erythrocytes

August 15, 2017 - 14:35 -- Open Access
Khai Lone Lim, Amirah Amir, Yee Ling Lau and Mun Yik Fong
Malaria Journal 2017 16:331, 11 August 2017

This study is the first report of phenotypic difference between PkDBPαII haplotypes.


NOT Open Access | An in silico strategy for identification of novel drug targets against Plasmodium falciparum

August 14, 2017 - 15:58 -- NOT Open Access
Subhashree Rout, Namrata Priyadarshini Patra & Rajani Kanta Mahapatra
Parasitology Research, September 2017, Volume 116, Issue 9, pp 2539–2559

The apicomplexan parasite Plasmodium falciparum is responsible for global malaria burden. With the reported resistance to artemisinin chemotherapy, there is an urgent need to maintain early phase drug discovery and identify novel drug targets for successful eradication of the pathogen from the host.

Hydrophilic-treated plastic plates for wide-range analysis of Giemsa-stained red blood cells and automated Plasmodium infection rate counting

August 10, 2017 - 06:39 -- Open Access
Muneaki Hashimoto, Shouki Yatsushiro, Masatoshi Kataoka, et al.
Malaria Journal 2017 16:321, 8 August 2017

Because the running cost of these methods is very low and they do not involve complicated techniques, the use of hydrophilic COC plates may contribute to improved and more accurate diagnosis and research of malaria.

Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs

May 25, 2017 - 08:09 -- Open Access
Amelia E. Hanron, Zachary P. Billman, Sean C. Murphy, et al.
Malaria Journal 2017 16:208, 19 May 2017

Because the spliced target does not require DNase treatment, the PF3D7_0630000 assay can be multiplexed with Plasmodium 18S rRNA for direct one-step detection of gametocytes from whole human blood.

High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations

April 25, 2017 - 15:50 -- Open Access
Yaye Dié Ndiaye, Cyrille K. Diédhiou, Daouda Ndiaye, et al.
Malaria Journal 2017 16:153, 19 April 2017

Here the results demonstrate that HRM is a rapid, sensitive, and field-deployable alternative technique to PCR–RFLP genotyping that is useful in populations harbouring more than one parasite genome (polygenomic infections).


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