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plasmodium

NOT Open Access | Platelet Induction of the Acute-Phase Response Is Protective in Murine Experimental Cerebral Malaria

April 2, 2013 - 14:03 -- NOT Open Access
Author(s): 
Angela A. Aggrey, Kalyan Srivastava, Sara Ture, David J. Field, and Craig N. Morrell
Reference: 
The Journal of Immunology March 27, 2013
MalariaWorld

Our data now suggest that platelets have a complex role in ECM pathogenesis: platelets help limit parasite growth early postinfection, but with continued platelet activation as the disease progresses, platelets contribute to ECM-associated inflammation.

Misclassification of Plasmodium infections by conventional microscopy and the impact of remedial training on the proficiency of laboratory technicians in species identification

April 2, 2013 - 13:55 -- Open Access
Author(s): 
Obare P, Ogutu B, Adams M, Odera JS, Lilley K, Dosoo D, Adhiambo C, Owusu-Agyei S, Binka F, Wanja E, Johnson J
Reference: 
Malaria Journal 2013, 12:113 (27 March 2013)
MalariaWorld

 This work explores misclassifications of four Plasmodium species by conventional microscopy in relation to the proficiency of microscopists and morphological characteristics of the parasites on Giemsa-stained blood films.

Comparison of PfHRP-2/pLDH ELISA, qPCR and Microscopy for the Detection of Plasmodium Events and Prediction of Sick Visits during a Malaria Vaccine Study

March 27, 2013 - 08:27 -- Open Access
Author(s): 
Ismail Mahat Bashir, Nekoye Otsyula, George Awinda, Michele Spring, Petra Schneider, John Njenga Waitumbi
Reference: 
PLoS ONE 8(3): e56828
MalariaWorld

PfHRP-2 ELISA and qPCR may be needed for accurately quantifying the malaria parasite burden.

NOT Open Access | Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites

March 6, 2013 - 06:55 -- NOT Open Access
Author(s): 
Tyrell Towle, Isabel Chang, Robert J. Kerns, Purnima Bhanot
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 6, 15 March 2013, Pages 1874–1877
MalariaWorld

Malaria is a disease that has a major impact in many developing nations, especially on the African continent.

Continent: 

The story of artesunate--mefloquine (ASMQ), innovative partnerships in drug development: case study

February 26, 2013 - 09:17 -- Open Access
Author(s): 
Wells S, Diap G, Kiechel J
Reference: 
Malaria Journal 2013, 12:68 (21 February 2013)
MalariaWorld

This collaborative approach to drug development involving international partnerships and independent funding mechanisms is a powerful new way to develop drugs for tropical diseases.

NOT Open Access | Red Blood Cell Polymorphism and Susceptibility to Plasmodium vivax

February 14, 2013 - 08:20 -- NOT Open Access
Author(s): 
Peter A. Zimmerman, Marcelo U. Ferreira, Rosalind E. Howes, Odile Mercereau-Puijalon
Reference: 
Advances in Parasitology, Volume 81, 2013, Pages 27–76
MalariaWorld

In this chapter, we review the evidence for P. vivax Duffy-dependent and Duffy-independent red cell invasion.

Expression of Cytosolic Peroxiredoxins in Plasmodium berghei Ookinetes Is Regulated by Environmental Factors in the Mosquito Bloodmeal

February 6, 2013 - 10:16 -- Open Access
Author(s): 
Benjamin A. Turturice, Michael A. Lamm, James J. Tasch, Angelika Zalewski, Rachel Kooistra, Eric H. Schroeter, Sapna Sharma, Shin-Ichiro Kawazu, Stefan M. Kanzok
Reference: 
PLoS Pathog 9(1): e1003136
MalariaWorld

The Plasmodium ookinete develops over several hours in the bloodmeal of its mosquito vector where it is exposed to exogenous stresses, including cytotoxic reactive oxygen species (ROS).

Not Open Access | Machine learning approach for automated screening of malaria parasite using light microscopic images

February 5, 2013 - 16:17 -- NOT Open Access
Author(s): 
Dev Kumar Das, Madhumala Ghosh, Mallika Pal, Asok K. Maiti, Chandan Chakraborty
Reference: 
Micron, Volume 45, February 2013, Pages 97–106
MalariaWorld

The aim of this paper is to address the development of computer assisted malaria parasite characterization and classification using machine learning approach based on light microscopic images of peripheral blood smears.

Not Open Access | Parasitological and new molecular-phylogenetic characterization of the malaria parasite Plasmodium tejerai in South American penguins

January 31, 2013 - 04:37 -- NOT Open Access
Author(s): 
Patricia Silveira, Nayara O. Belo, Gustavo A. Lacorte, Cristiane K.M. Kolesnikovas, Ralph E.T. Vanstreels, Mário Steindel, José Luiz Catão-Dias, Gediminas Valkiūnas, Érika M. Braga
Reference: 
Parasitology International, Volume 62, Issue 2, April 2013, Pages 165-171
MalariaWorld

This study is the first report on mortality of Spheniscus magellanicus, penguin of South America, caused by Plasmodium tejerai, which was identified using morphological and molecular analyses.

Continent: 

Lack of Plasmodium vivax infections and high frequency of the erythroid silent Duffy antigen genotype in Haiti

January 28, 2013 - 15:22 -- Open Access
Author(s): 
Weppelmann TA, Carter TE, Chen Z, von Fricken ME, Memnon G, Victor YS, Existe A, Okech BA
Reference: 
Malaria Journal 2013, 12:30 (24 January 2013)
MalariaWorld

This study investigated the frequency of the FYES allele and P. vivax infections in malaria patients with the goal of uncovering factors for the lack of P. vivax infections reported in Haiti.

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