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Not Open Access | Plasmodium comparative genomics

November 26, 2019 - 20:33 -- NOT Open Access
Lisa Ranford-Cartwright, Elena Gómez-Díaz
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 267–269

Malaria is a serious infectious disease caused by unicellular eukaryotic parasites of the genus Plasmodium. Today more than 200 species exist [1], and whole-genome sequence data is available for around 22 species 

Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium

November 26, 2019 - 20:31 -- Open Access
Marcus C S Lee, Scott E Lindner, Jose-Juan Lopez-Rubio, Manuel Llinás
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 281–289

CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics across a wide range of organisms, including the Plasmodium parasites that cause malaria. The ability to deliver single point mutations, epitope tags and gene deletions at increased speed and scale is enabling our understanding of the biology of these complex parasites, and pointing to potential new therapeutic targets. In this review, we describe some of the biological and technical considerations for designing CRISPR-based experiments, and discuss potential future developments that broaden the applications for CRISPR/Cas9 interrogation of the malaria parasite genome.

Not Open Access | The second life of Plasmodium in the mosquito host: gene regulation on the move

November 26, 2019 - 18:16 -- NOT Open Access
José L Ruiz, Elena Gómez-Díaz
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 313–357

Malaria parasites face dynamically changing environments and strong selective constraints within human and mosquito hosts. To survive such hostile and shifting conditions, Plasmodium switches transcriptional programs during development and has evolved mechanisms to adjust its phenotype through heterogeneous patterns of gene expression. In vitro studies on culture-adapted isolates have served to set the link between chromatin structure and functional gene expression.

Singultus as an Unusual Debut of Plasmodium vivax Malaria

November 19, 2019 - 15:14 -- Open Access
Guadarrama-Conzuelo F, Saad Manzanera AD.
Cureus. 2019 Sep 1;11(9):e5548.

We describe this previously unreported association, hypothesize on the potential mechanism and review the literature on singultus and unusual presentations of Plasmodium infections.

The burden of submicroscopic and asymptomatic malaria in India revealed from epidemiology studies at three varied transmission sites in India

November 19, 2019 - 14:53 -- Open Access
Anna Maria van Eijk, Patrick L. Sutton, Alex Eapen, et al.
Scientific Reports volume 9, Article number: 17095 (2019)

Exploratory spatial analysis identified a number of potential malaria hotspots at all three sites. There is a considerable burden of submicroscopic and asymptomatic malaria in malarious regions in India, which may act as a reservoir with implications for malaria elimination strategies.


A patatin-like phospholipase functions during gametocyte induction in the malaria parasite Plasmodium falciparum

November 18, 2019 - 16:21 -- Open Access
Flammersfeld A, Panyot A, Yamaryo-Botté Y, Aurass P, Przyborski JM, Flieger A, Botté C, Pradel G.
Cell Microbiol. 2019 Nov 16:e13146

Patatin-like phospholipases (PNPLAs) are highly conserved enzymes of prokaryotic and eukaryotic organisms with major roles in lipid homeostasis. The genome of the malaria parasite Plasmodium falciparum encodes four putative PNPLAs with predicted functions during phospholipid degradation.

The nuclear 18S ribosomal DNAs of avian haemosporidian parasites

September 10, 2019 - 15:36 -- Open Access
Josef Harl, Tanja Himmel, Gediminas Valkiūnas and Herbert Weissenböck
Malaria Journal 2019 18:305, 3 September 2019

Plasmodium species feature only four to eight nuclear ribosomal units on different chromosomes, which are assumed to evolve independently according to a birth-and-death model, in which new variants originate by duplication and others are deleted throughout time. Moreover, distinct ribosomal units were shown to be expressed during different developmental stages in the vertebrate and mosquito hosts. Here, the 18S rDNA sequences of 32 species of avian haemosporidian parasites are reported and compared to those of simian and rodent Plasmodium species.

Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

September 10, 2019 - 15:34 -- Open Access
Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan
Malaria Journal 2019 18:304, 3 September 2019

Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium falciparum malaria infection during pregnancy, and intermittent preventive treatment of malaria during pregnancy (IPTp), on the risk of clinical malaria or parasitaemia during infancy.


Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges

September 10, 2019 - 15:29 -- Open Access
Deus S. Ishengoma, Queen Saidi, Carol H. Sibley, Cally Roper and Michael Alifrangis
Malaria Journal 2019 18:267, 3 September 2019

Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies.

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

September 10, 2019 - 15:15 -- Open Access
Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John and Anne E. P. Frosch
Malaria Journal 2019 18:297, 30 August 2019

HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses.



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