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NOT Open Access | Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii

February 1, 2018 - 15:57 -- NOT Open Access
Joseph M. Varberg, Kaice A. LaFavers, Gustavo Arrizabalaga and William J. Sullivan Jr.
Antimicrob. Agents Chemother. February 2018 vol. 62 no. 2 e01489-17

Protozoan parasites, including the apicomplexan pathogens Plasmodium falciparum (which causes malaria) and Toxoplasma gondii (which causes toxoplasmosis), infect millions of people worldwide and represent major human disease burdens.

State-dependent domicile leaving rates in Anopheles gambiae

January 16, 2018 - 15:52 -- Open Access
Simon P. W. Zappia, Alex M. Chubaty and Bernard D. Roitberg
Malaria Journal 2018 17:25, 12 January 2018

The results confirm that mosquito-leaving behaviour is energy-state dependent, and provide some of the first evidence of state-dependent domicile emigration in An. gambiae, which may play a role in malarial transmission dynamics.

NOT Open Access | Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

December 19, 2017 - 15:33 -- NOT Open Access
Min Zhang, Julio Gallego-Delgado, Cristina Fernandez-Arias, Norman C. Waters, Ana Rodriguez, Moriya Tsuji, Ronald C. Wek, Victor Nussenzweig, William J. Sullivan
Cell Host & Microbe, Volume 22, Issue 6, 13 December 2017, Pages 766–776.e4

Artemisinin and its derivatives (ARTs) are frontline antimalarial drugs.

NOT Open Access | Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior

August 23, 2017 - 16:01 -- NOT Open Access
Watcharee Amornwatcharapong, Somchart Maenpuen, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Archives of Biochemistry and Biophysics, Volume 630, 15 September 2017, Pages 91-100

Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis.

The effectiveness of non-pyrethroid insecticide-treated durable wall lining to control malaria in rural Tanzania: study protocol for a two-armed cluster randomized trial

August 15, 2017 - 16:36 -- Open Access
Mtove G, Mugasa J, Messenger L, Malima R, Mangesho P, Magogo F, Plucinski M, Hashimu R, Matowo J, Shepard D, Batengana B, Cook J, Emidi B, Halasa Y, Kaaya R, Kihombo A, Lindblade K, Makenga G, Mpangala R, Mwambuli A, Mzava R, Mziray A, Olang G, Oxborough R, Seif M, Sambu E, Samuels A, Sudi W, Thomas J, Weston S, Alilio M, Binkin N, Gimnig J, Kleinschmidt I, McElroy P, Moulton L, Norris L, Ruebush T, Venkatesan M, Rowland M, Mosha F, Kisinza W
BMC Public Health 2016, 16 :633 (25 July 2016)

This protocol describes the large-scale evaluation of a novel vector control product, designed to overcome some of the known limitations of existing methods.

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

August 15, 2017 - 16:30 -- Open Access
Drew D, Wilson D, Elliott S, Cross N, Terheggen U, Hodder A, Siba P, Chelimo K, Dent A, Kazura J, Mueller I, Beeson J
BMC Medicine 2016, 14 :144 (23 September 2016)

We found that AMA1 was a major target of naturally acquired invasion-inhibitory antibodies that were highly prevalent in malaria-endemic populations and showed a high degree of allele specificity. Significantly, the prevalence of inhibitory antibodies to different alleles varied substantially within populations and between geographic locations.

An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia

August 15, 2017 - 16:18 -- Open Access
Leang R, Khu N, Mukaka M, Debackere M, Tripura R, Kheang S, Chy S, Kak N, Buchy P, Tarantola A, Menard D, Roca-Felterer A, Fairhurst R, Kheng S, Muth S, Ngak S, Dondorp A, White N, Taylor W
BMC Medicine 2016, 14 :171 (27 October 2016)

In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. 

Life-span of in vitro differentiated Plasmodium falciparum gametocytes

August 15, 2017 - 14:37 -- Open Access
Tamirat Gebru, Albert Lalremruata, Peter G. Kremsner, Benjamin Mordmüller and Jana Held
Malaria Journal 2017 16:330, 11 August 2017

Plasmodium falciparum mature gametocytes can survive up to 16–32 days (at least 14 days for mature male gametocytes) in vitro in absence of the influence of host factors.

The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo show different binding activity level to human erythrocytes

August 15, 2017 - 14:35 -- Open Access
Khai Lone Lim, Amirah Amir, Yee Ling Lau and Mun Yik Fong
Malaria Journal 2017 16:331, 11 August 2017

This study is the first report of phenotypic difference between PkDBPαII haplotypes.


NOT Open Access | An in silico strategy for identification of novel drug targets against Plasmodium falciparum

August 14, 2017 - 15:58 -- NOT Open Access
Subhashree Rout, Namrata Priyadarshini Patra & Rajani Kanta Mahapatra
Parasitology Research, September 2017, Volume 116, Issue 9, pp 2539–2559

The apicomplexan parasite Plasmodium falciparum is responsible for global malaria burden. With the reported resistance to artemisinin chemotherapy, there is an urgent need to maintain early phase drug discovery and identify novel drug targets for successful eradication of the pathogen from the host.


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