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plasmodium

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

February 5, 2014 - 02:21 -- Open Access
Author(s): 
Marco A. Ataide, Warrison A. Andrade, Ricardo T. Gazzinelli, et al.
Reference: 
PLoS Pathog 10(1): e1003885

In this report, we describe a signature for the expression of inflammasome-related genes and caspase-1 activation in malaria. Indeed, when we infected mice, Plasmodium infection was sufficient to promote MyD88-mediated caspase-1 activation, dependent on IFN-γ-priming and the expression of inflammasome components ASC, P2X7R, NLRP3 and/or NLRP12

Evolution of Chloroplast Transcript Processing in Plasmodium and Its Chromerid Algal Relatives

January 22, 2014 - 14:58 -- Open Access
Author(s): 
Richard G. Dorrell, James Drew, R. Ellen R. Nisbet, Christopher J. Howe
Reference: 
PLoS Genet 10(1): e1004008

We additionally present evidence that poly(U) tail addition in chromerids is involved in the alternative processing of polycistronic precursors covering multiple photosynthesis genes, and appears to be associated with high levels of transcript abundance.

Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites

January 20, 2014 - 18:18 -- Open Access
Author(s): 
Zhou D, Zhang D, Zhu C,et al.
Reference: 
BMC Genomics 2014, 15 :42 (18 January 2014)

The A. sinensis genome produced in this study, provides an important resource for analyzing the genetic basis of susceptibility and resistance of mosquitoes to Plasmodium parasites research which will ultimately facilitate the design of urgently needed interventions against this debilitating mosquito-borne disease.

Not Open Access | Plasmodium Products Contribute to Severe Malarial Anemia by Inhibiting Erythropoietin-Induced Proliferation of Erythroid Precursors

December 17, 2013 - 19:13 -- NOT Open Access
Author(s): 
Neeta Thawani, Mifong Tam, Marie-Josée Bellemare, D. Scott Bohle, Martin Olivier, J. Brian de Souza and Mary M. Stevenson
Reference: 
J Infect Dis. (2014) 209 (1): 140-149

To determine whether Hz contributes to malarial anemia, P. yoelii–derived or synthetic Hz was administered to naive mice, and the development of anemia, reticulocytosis, and RBC turnover was determined.

A case report of transfusion-transmitted Plasmodium malariae from an asymptomatic non-immune traveller

December 11, 2013 - 08:35 -- Open Access
Author(s): 
Brouwer EE, van Hellemond JJ, van Genderen PJ, Slot E, van Lieshout L, Visser LG, Wismans PJ
Reference: 
Malaria Journal 2013, 12 :439 (5 December 2013)

Background

The incidence of transfusion-transmitted malaria is very low in non-endemic countries due to strict donor selection. The optimal strategy to mitigate the risk of transfusion-transmitted malaria in non-endemic countries without unnecessary exclusion of blood donations is, however, still debated and asymptomatic carriers of Plasmodium species may still be qualified to donate blood for transfusion purposes.

Review | Escaping the immune system: How the malaria parasite makes vaccine development a challenge

December 4, 2013 - 16:48 -- Open Access
Author(s): 
Danielle I. Stanisic, Alyssa E. Barry, Michael F. Good
Reference: 
Trends in Parasitology, Volume 29, Issue 12, December 2013, Pages 612-622
MalariaWorld

With data from Phase III trials indicating that the leading malaria vaccine candidate, RTS,S, has limited efficacy, it is necessary to reconsider approaches to the development of a vaccine capable of inducing long-lived protection.

Not Open Access | Imaging of the spleen in malaria

November 28, 2013 - 13:51 -- NOT Open Access
Author(s): 
Mireia Ferrer, Lorena Martin-Jaular, Mariana De Niz, Shahid M. Khan, Chris J. Janse, Maria Calvo, Volker Heussler, Hernando A. del Portillo
Reference: 
Parasitology International, Volume 63, Issue 1, February 2014, Pages 195-205
MalariaWorld

Here, we review imaging techniques used for studying the malarious spleen, from optical microscopy to in vivo imaging, and discuss the bright perspectives of evolving technologies in our present understanding of the role of this organ in infections caused by Plasmodium.

Not Open Access | Rodent Plasmodium-infected red blood cells: Imaging their fates and interactions within their hosts

November 28, 2013 - 13:37 -- NOT Open Access
Author(s): 
Carla Claser, Benoit Malleret, Kaitian Peng, Nadja Bakocevic, Sin Yee Gun, Bruce Russell, Lai Guan Ng, Laurent Rénia
Reference: 
Parasitology International, Volume 63, Issue 1, February 2014, Pages 187-194
MalariaWorld

Here, we review the different techniques that allow researchers to study how rodent malaria parasites modify their host cells, the distribution of IRBCs in vivo as well as the interactions between IRBCs and host tissues.

NOT Open Access | Description and molecular characterization of Plasmodium (Novyella) unalis sp. nov. from the Great Thrush (Turdus fuscater) in highland of Colombia

November 26, 2013 - 13:35 -- NOT Open Access
Author(s): 
Juan S. Mantilla, Angie D. González, Gediminas Valkiūnas, Ligia I. Moncada & Nubia E. Matta
Reference: 
Parasitology Research, December 2013, Volume 112, Issue 12, pp 4193-4204
MalariaWorld

Plasmodium (Novyella) unalis sp. nov. was found in the Great Thrush, Turdus fuscater (Passeriformes, Turdidae) in Bogotá, Colombia, at 2,560 m above sea level where the active transmission occurs.

Country: 

Population genetics of Plasmodium falciparum and Plasmodium vivax and asymptomatic malaria in Temotu Province, Solomon Islands

November 26, 2013 - 13:25 -- Open Access
Author(s): 
Gray K, Dowd S, Bain L, Bobogare A, Wini L, Shanks DG, Cheng Q
Reference: 
Malaria Journal 2013, 12 :429 (22 November 2013)
MalariaWorld

The low diversity and clonal population of P. falciparum population may partially account for clinical immunity developed against illness.

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