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plasmodium

NOT Open Access | Can Wolbachia modulate the fecundity costs of Plasmodium in mosquitoes?

July 3, 2018 - 16:30 -- NOT Open Access
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Author(s): 
F Zélé, J Denoyelle, O Duron and A Rivero
Reference: 
Parasitology, Volume 145 / Issue 6, May 2018, pp 770 – 774

Although Wolbachia-infected mosquitoes fare overall better than uninfected ones, Wolbachia does not confer a sufficiently high reproductive boost to mosquitoes to compensate for the reproductive losses inflicted by Plasmodium.

Paleopathological Considerations on Malaria Infection in Korea before the 20th Century

May 10, 2018 - 15:48 -- Open Access
Author(s): 
Dong Hoon Shin, Min Seo, Jong Ha Hong, and Eunju Lee
Reference: 
BioMed Research International, Volume 2018, Article ID 8516785, 14 pages

In this article, we first review the history of malarial infection in Korea by means of studies on Joseon documents and the related scientific data on the evolutionary history of P. vivax in Asia. 

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Molecular approaches to determine the multiplicity of Plasmodium infections

April 24, 2018 - 15:31 -- Open Access
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Author(s): 
Daibin Zhong, Cristian Koepfli, Liwang Cui and Guiyun Yan
Reference: 
Malaria Journal 2018 17:172, 23 April 2018

Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the number of genetically distinct parasite strains co-infecting a single host, which is an important indicator of malaria epidemiology.

NOT Open Access | ATAC-ing Transcriptional Mysteries in Malaria Parasites

April 19, 2018 - 15:27 -- NOT Open Access
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Author(s): 
Catherine J. Merrick
Reference: 
Cell Host & Microbe Volume 23, Issue 4, 11 April 2018, Pages 425-426

Ever since Plasmodium intraerythrocytic development was reported to proceed via an unusual “hardwired” transcriptional cascade, the control of gene transcription in malaria parasites has been an area of intense investigation.

Not Open Access | Plasmodium-associated changes in human odor attract mosquitoes

April 19, 2018 - 15:26 -- NOT Open Access
Author(s): 
Ailie Robinson, Annette O. Busula, Jetske G. de Boer, et al.
Reference: 
PNAS April 16, 2018. 201721610

Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector–host contacts and increased transmission.

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

April 11, 2018 - 14:28 -- Open Access
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Author(s): 
Shang Ma, Stuart Cahalan, Ardem Patapoutian, et al.
Reference: 
Cell, Volume 173, Issue 2, 5 April 2018, Pages 443-455.e12

Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis.

NOT Open Access | Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii

February 1, 2018 - 15:57 -- NOT Open Access
Author(s): 
Joseph M. Varberg, Kaice A. LaFavers, Gustavo Arrizabalaga and William J. Sullivan Jr.
Reference: 
Antimicrob. Agents Chemother. February 2018 vol. 62 no. 2 e01489-17

Protozoan parasites, including the apicomplexan pathogens Plasmodium falciparum (which causes malaria) and Toxoplasma gondii (which causes toxoplasmosis), infect millions of people worldwide and represent major human disease burdens.

State-dependent domicile leaving rates in Anopheles gambiae

January 16, 2018 - 15:52 -- Open Access
Author(s): 
Simon P. W. Zappia, Alex M. Chubaty and Bernard D. Roitberg
Reference: 
Malaria Journal 2018 17:25, 12 January 2018

The results confirm that mosquito-leaving behaviour is energy-state dependent, and provide some of the first evidence of state-dependent domicile emigration in An. gambiae, which may play a role in malarial transmission dynamics.

NOT Open Access | Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

December 19, 2017 - 15:33 -- NOT Open Access
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Author(s): 
Min Zhang, Julio Gallego-Delgado, Cristina Fernandez-Arias, Norman C. Waters, Ana Rodriguez, Moriya Tsuji, Ronald C. Wek, Victor Nussenzweig, William J. Sullivan
Reference: 
Cell Host & Microbe, Volume 22, Issue 6, 13 December 2017, Pages 766–776.e4

Artemisinin and its derivatives (ARTs) are frontline antimalarial drugs.

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