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NOT Open Access | ATAC-ing Transcriptional Mysteries in Malaria Parasites

April 19, 2018 - 15:27 -- NOT Open Access
Catherine J. Merrick
Cell Host & Microbe Volume 23, Issue 4, 11 April 2018, Pages 425-426

Ever since Plasmodium intraerythrocytic development was reported to proceed via an unusual “hardwired” transcriptional cascade, the control of gene transcription in malaria parasites has been an area of intense investigation.

Not Open Access | Plasmodium-associated changes in human odor attract mosquitoes

April 19, 2018 - 15:26 -- NOT Open Access
Ailie Robinson, Annette O. Busula, Jetske G. de Boer, et al.
PNAS April 16, 2018. 201721610

Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector–host contacts and increased transmission.

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

April 11, 2018 - 14:28 -- Open Access
Shang Ma, Stuart Cahalan, Ardem Patapoutian, et al.
Cell, Volume 173, Issue 2, 5 April 2018, Pages 443-455.e12

Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis.

NOT Open Access | Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii

February 1, 2018 - 15:57 -- NOT Open Access
Joseph M. Varberg, Kaice A. LaFavers, Gustavo Arrizabalaga and William J. Sullivan Jr.
Antimicrob. Agents Chemother. February 2018 vol. 62 no. 2 e01489-17

Protozoan parasites, including the apicomplexan pathogens Plasmodium falciparum (which causes malaria) and Toxoplasma gondii (which causes toxoplasmosis), infect millions of people worldwide and represent major human disease burdens.

State-dependent domicile leaving rates in Anopheles gambiae

January 16, 2018 - 15:52 -- Open Access
Simon P. W. Zappia, Alex M. Chubaty and Bernard D. Roitberg
Malaria Journal 2018 17:25, 12 January 2018

The results confirm that mosquito-leaving behaviour is energy-state dependent, and provide some of the first evidence of state-dependent domicile emigration in An. gambiae, which may play a role in malarial transmission dynamics.

NOT Open Access | Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

December 19, 2017 - 15:33 -- NOT Open Access
Min Zhang, Julio Gallego-Delgado, Cristina Fernandez-Arias, Norman C. Waters, Ana Rodriguez, Moriya Tsuji, Ronald C. Wek, Victor Nussenzweig, William J. Sullivan
Cell Host & Microbe, Volume 22, Issue 6, 13 December 2017, Pages 766–776.e4

Artemisinin and its derivatives (ARTs) are frontline antimalarial drugs.

NOT Open Access | Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior

August 23, 2017 - 16:01 -- NOT Open Access
Watcharee Amornwatcharapong, Somchart Maenpuen, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Archives of Biochemistry and Biophysics, Volume 630, 15 September 2017, Pages 91-100

Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis.

The effectiveness of non-pyrethroid insecticide-treated durable wall lining to control malaria in rural Tanzania: study protocol for a two-armed cluster randomized trial

August 15, 2017 - 16:36 -- Open Access
Mtove G, Mugasa J, Messenger L, Malima R, Mangesho P, Magogo F, Plucinski M, Hashimu R, Matowo J, Shepard D, Batengana B, Cook J, Emidi B, Halasa Y, Kaaya R, Kihombo A, Lindblade K, Makenga G, Mpangala R, Mwambuli A, Mzava R, Mziray A, Olang G, Oxborough R, Seif M, Sambu E, Samuels A, Sudi W, Thomas J, Weston S, Alilio M, Binkin N, Gimnig J, Kleinschmidt I, McElroy P, Moulton L, Norris L, Ruebush T, Venkatesan M, Rowland M, Mosha F, Kisinza W
BMC Public Health 2016, 16 :633 (25 July 2016)

This protocol describes the large-scale evaluation of a novel vector control product, designed to overcome some of the known limitations of existing methods.

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

August 15, 2017 - 16:30 -- Open Access
Drew D, Wilson D, Elliott S, Cross N, Terheggen U, Hodder A, Siba P, Chelimo K, Dent A, Kazura J, Mueller I, Beeson J
BMC Medicine 2016, 14 :144 (23 September 2016)

We found that AMA1 was a major target of naturally acquired invasion-inhibitory antibodies that were highly prevalent in malaria-endemic populations and showed a high degree of allele specificity. Significantly, the prevalence of inhibitory antibodies to different alleles varied substantially within populations and between geographic locations.


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