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plasmodium

Plasmodium knowlesi and other malaria parasites in long-tailed macaques from the Philippines

April 29, 2019 - 13:15 -- Open Access
Author(s): 
Lief Erikson Gamalo, Judeline Dimalibot, Khamisah Abdul Kadir, Balbir Singh and Vachel Gay Paller
Reference: 
Malaria Journal 2019 18:147, 24 April 2019

Macaca fascicularis (long-tailed macaque) is the most widespread species of macaque in Southeast Asia and the only species of monkey found naturally in the Philippines. The species is the natural host for the zoonotic malaria species, Plasmodium knowlesi and Plasmodium cynomolgi and for the potentially zoonotic species, Plasmodium inui. Moreover, other Plasmodium species such as Plasmodium coatneyi and Plasmodium fieldi are also natural parasites of M. fascicularis. The aims of this study were to identify and determine the prevalence of Plasmodium species infecting wild and captive long-tailed macaques from the Philippines.

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Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi

April 29, 2019 - 13:13 -- Open Access
Author(s): 
Sakineh Pirahmadi, Sedigheh Zakeri, Akram A. Mehrizi, Navid D. Djadid, Abbas-Ali Raz, Jafar J. Sani, Ronak Abbasi and Zahra Ghorbanzadeh
Reference: 
Malaria Journal 2019 18:146, 24 April 2019

Plasmodium falciparum parasite is the most deadly species of human malaria, and the development of an effective vaccine that prevents P. falciparum infection and transmission is a key target for malarial elimination and eradication programmes. P. falciparum cell-traversal protein for ookinetes and sporozoites (PfCelTOS) is an advanced vaccine candidate. A comparative study was performed to characterize the immune responses in BALB/c mouse immunized with Escherichia coli-expressed recombinant PfCelTOS (rPfCelTOS) in toll-like receptor (TLR)-based adjuvants, CpG and Poly I:C alone or in combination (CpG + Poly I:C), followed by the assessment of transmission-reducing activity (TRA) of anti-rPfCelTOS antibodies obtained from different vaccine groups in Anopheles stephensi.

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NOT Open Access | Co‐infections with Plasmodium, Ascaris and Giardia among Rwandan schoolchildren

April 9, 2019 - 13:10 -- NOT Open Access
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Author(s): 
Dominik Geus, Kevin C. Sifft, Frank P. Mockenhaupt, et al.
Reference: 
Tropical Medicine & International Health, Volume24, Issue4 April 2019 Pages 409-420

Parasitic co‐infections are common in Rwandan schoolchildren, and are associated with a rather silent clinical manifestation that nevertheless may affect school performance and long‐term development.

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Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates

December 12, 2018 - 16:13 -- Open Access
Author(s): 
Jyotsana Dixit, Arun Zachariah, Sajesh P. K., Bathrachalam Chandramohan, Vinoth Shanmuganatham, K. Praveen Karanth
Reference: 
PLoS Negl Trop Dis 12(12): e0006801

Many human parasites and pathogens have closely related counterparts among non-human primates.

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Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection

November 28, 2018 - 15:26 -- Open Access
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Author(s): 
Qianqian Cheng, Jian Liu, Yujun Pei, Yaolin Zhang, Dawang Zhou, Weiqing Pan, Jiyan Zhang
Reference: 
PLoS Pathog 14(11): e1007440

Plasmodium infection, both for IFN-γ-dependent effector mechanisms and providing B cell helper signals.

An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria

October 2, 2018 - 16:35 -- Open Access
Author(s): 
Ana C. Bahia, Marina S. Kubota, Yara M. Traub-Csekö, et al.
Reference: 
PLoS Negl Trop Dis 12(9): e0006785

Innate immunity is an ancient and conserved defense system that provides an early effective response against invaders.

NOT Open Access | Malaria parasite translocon structure and mechanism of effector export

September 11, 2018 - 14:53 -- NOT Open Access
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Author(s): 
Chi-Min Ho, Josh R. Beck, Mason Lai, Yanxiang Cui, Daniel E. Goldberg, Pascal F. Egea & Z. Hong Zhou
Reference: 
Nature volume 561, pages70–75 (2018)

The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of malarial effector proteins across a parasite-encasing vacuolar membrane into host erythrocytes, but the mechanism of this process remains unknown.

Avian malaria co-infections confound infectivity and vector competence assays of Plasmodium homopolare

July 26, 2018 - 16:14 -- Open Access
Author(s): 
Jenny S. Carlson, Brittany Nelms, Christopher M. Barker, William K. Reisen, Ravinder N. M. Sehgal & Anthony J. Cornel
Reference: 
Parasitology Research August 2018, Volume 117, Issue 8, pp 2385–2394

Currently, there are very few studies of avian malaria that investigate relationships among the host-vector-parasite triad concomitantly.

Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments

July 19, 2018 - 16:52 -- Open Access
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Author(s): 
Ross G. Douglas, Prajwal Nandekar, Friedrich Frischknecht, et al.
Reference: 
PLoS Biol 16(7): e2005345

Cell motility is essential for protozoan and metazoan organisms and typically relies on the dynamic turnover of actin filaments.

NOT Open Access | Combination of artemisinin-based natural compounds from Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies

July 6, 2018 - 14:27 -- NOT Open Access
Author(s): 
Jing Li, Chao Zhang, Muxin Gong and Manyuan Wang
Reference: 
Phytotherapy Research banner Volume32, Issue7 July 2018 Pages 1415-1420

Currently, the most effective antimalarial is artemisinin, which is extracted from the leaves of medicinal herb Artemisia annua L. (A. annua).

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