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plasmodium infection

Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection

April 14, 2019 - 16:37 -- Open Access
Mark J. Hanemaaijer, Hannah Higgins, Ipek Eralp, Youki Yamasaki, Norbert Becker, Oscar D. Kirstein, Gregory C. Lanzaro and Yoosook Lee
Malaria Journal 2019 18:127, 11 April 2019

This paper is the first report providing divergence island SNP genotypes for natural population of Burkina Faso and corresponding Plasmodium infection rates.


Non-invasive surveillance of Plasmodium infection by real-time PCR analysis of ethanol preserved faeces from Ugandan school children with intestinal schistosomiasis

April 4, 2019 - 15:36 -- Open Access
Hajri Al-Shehri, B. Joanne Power, J. Russell Stothard, et al.
Malaria Journal 2019 18:109, 1 April 2019

In this high transmission setting, EPF sampling with rtPCR analysis has satisfactory diagnostic performance in estimation of mean prevalence and prevalence by school upon direct comparison with POC-RDTs.

Medical Treatment: 

Not Open Access | Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection

July 26, 2017 - 17:46 -- NOT Open Access
David S. Khoury, Deborah Cromer, Miles P. Davenport, et al.
PNAS July 18, 2017 vol. 114 no. 29 7701-7706

Severe malaria and associated high parasite burdens occur more frequently in humans lacking robust adaptive immunity to Plasmodium falciparum.

NOT Open Access | Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations

June 21, 2017 - 15:40 -- NOT Open Access
Maxmillian Mpina, Nicholas J. Maurice, Martin Prlic, et al.
The Journal of Immunology, Vol. 199, Issue 1, 1 Jul 2017

Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following Plasmodium infection.

Not Open Access | Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response

April 18, 2017 - 15:26 -- NOT Open Access
Irene Gramaglia, Joyce Velez, Valery Combes, Georges E. R. Grau, Melanie Wree, and Henri C. van der Heyde
Blood 129, Volume: 129, Issue: 12, Pages: 1669-1679

Clinical studies indicate that thrombocytopenia correlates with the development of severe falciparum malaria, suggesting that platelets either contribute to control of parasite replication, possibly as innate parasite killer cells or function in eliciting pathogenesis.

Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models

December 5, 2014 - 07:22 -- Open Access
Protus Arrey Tarkang, Faith A Okalebo, Lawrence S Ayong, Gabriel A Agbor, Anastasia N Guantai
Malaria Journal 2014, 13:456 (25 November 2014)

This study aimed at investigating the suppressive, prophylactic and curative activities of Nefang in Plasmodium infected rodent models.

NOT Open Access | Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria

November 15, 2012 - 07:41 -- NOT Open Access
Raffaella Gozzelino, Bruno Bezerril Andrade, Miguel P. Soares, et al.
Cell Host & Microbe, Volume 12, Issue 5, 15 November 2012, Pages 693–704

Disease tolerance is a defense strategy that limits the fitness costs of infection irrespectively of pathogen burden.


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