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plasmodium infection

The mechanisms of action of Plasmodium infection against cancer

July 14, 2021 - 10:30 -- Open Access
Author(s): 
Chen X, Qin L, Hu W, Adah D
Reference: 
Cell Commun Signal. 2021 Jul 9;19(1):74

Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumor angiogenesis, inhibits tumor growth and metastasis, and prolongs the survival time of tumor-bearing mice. Based on these studies, three clinical trials of Plasmodium immunotherapy for advanced cancers have been approved and are ongoing in China.

Strategic variants of CSP delivered as SynDNA vaccines demonstrate heterogeneity of immunogenicity and protection from Plasmodium infection in a murine model

June 22, 2021 - 14:11 -- Open Access
Author(s): 
Reeder SM, Bah MA, Tursi NJ, Brooks RC, Patel A, Esquivel R, Eaton A, Jhun H, Chu J, Kim K, Xu Z, Zavala F, Weiner DB
Reference: 
Infect Immun. 2021 Jun 21:IAI0072820

Malaria infects millions of people every year, and despite recent advances in controlling disease spread, such as vaccination, it remains a global health concern. The circumsporozoite protein (CSP) has long been acknowledged as a key target in anti-malarial immunity. Leveraging the DNA vaccine platform against this formidable pathogen, five synthetic DNA vaccines encoding variations of CSP were designed and studied: 3D7, GPI1, ΔGPI, TM, and DD2. Among the single CSP antigen constructs a range of immunogenicity was observed with ΔGPI generating the most robust immunity.

NOT Open Access | Diversity of Anopheles Gambiae s.l., Giles (Diptera: Culicidae) Larval Habitats in Urban Areas and Malaria Transmission in Bouake, Cote d'Ivoire

June 16, 2021 - 15:16 -- NOT Open Access
Author(s): 
Adja AM, Zoh DD, Sagna AB, Kpan DMS, Guindo-Coulibaly N, Yapi A, Chandre F
Reference: 
Vector Borne Zoonotic Dis. 2021 Jun 14

Malaria vectors are supposedly uncommon in urban areas owing to the lack of suitable breeding sites for their development. However, the maintenance in urban areas of traditional rural practices along with humanitarian crisis can create favorable conditions for malaria transmission. This study aimed to provide relevant entomological data on the risk of malaria transmission in the city of Bouaké, after the military-political crisis from 2002 to 2011 in Côte d'Ivoire.

Not Open Access | TLR4-endothelin axis controls syncytiotrophoblast motility and confers fetal protection in placental malaria

June 8, 2021 - 10:52 -- NOT Open Access
Author(s): 
Pandya Y, Marta A, Barateiro A, Bandeira CL, Dombrowski JG, Costa J, Marinho CRF, Penha-Gonçalves C
Reference: 
Infect Immun. 2021 Jun 1:IAI0080920

Pregnancy associated malaria is often associated with adverse pregnancy outcomes. Placental circulatory impairments are an intriguing and unsolved component of malaria pathophysiology. Here, we uncovered a TLR4-TRIF-endothelin axis that controls trophoblast motility and is linked to fetal protection during Plasmodium infection. In a cohort of 401 pregnancies from Northern Brazil we found that infection during pregnancy reduced expression of endothelin receptor B in syncytiotrophoblasts while endothelin expression was only affected during acute infection.

Parasite and Host Erythrocyte Kinomics of Plasmodium Infection

June 1, 2021 - 15:26 -- Open Access
Author(s): 
Adderley J, Williamson T, Doerig C
Reference: 
Trends Parasitol. 2021 Jun;37(6):508-524

Malaria remains a heavy public health and socioeconomic burden in tropical and subtropical regions. Increasing resistance against front-line treatments implies that novel targets for antimalarial intervention are urgently required.

High prevalence of asymptomatic Plasmodium infection in Bandafassi, South-East Senegal

May 18, 2021 - 13:37 -- Open Access
Author(s): 
Aida Sadikh Badiane, Tolla Ndiaye, Alphonse Birane Thiaw, Deme Awa Binta, Mamadou Alpha Diallo, Mame Cheikh Seck, Khadim Diongue, Mamane Nassirou Garba, Mouhamadou Ndiaye and Daouda Ndiaye
Reference: 
Malaria Journal 2021 20:218, 12 May 2021

Malaria control and elimination strategies are based on levels of transmission that are usually determined by data collected from health facilities. In endemic areas, asymptomatic Plasmodium infection is thought to represent the majority of infections, though they are not diagnosed nor treated. Therefore, there might be an underestimation of the malaria reservoir, resulting in inadequate control strategies. In addition, these untreated asymptomatic Plasmodium infections maintain transmission, making it difficult or impossible to reach malaria elimination goals. Thus, the aim of this study was to determine the prevalence of asymptomatic Plasmodium infections in southeastern Senegal.

Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection

May 13, 2021 - 12:42 -- Open Access
Author(s): 
Mandal RK, Denny JE, Namazzi R, Opoka RO, Datta D, John CC, Schmidt NW
Reference: 
Cell Rep. 2021 May 11;35(6):109094

Gut microbiota educate the local and distal immune system in early life to imprint long-term immunological outcomes while maintaining the capacity to dynamically modulate the local mucosal immune system throughout life. It is unknown whether gut microbiota provide signals that dynamically regulate distal immune responses following an extra-gastrointestinal infection.

NOT Open Access | A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase

May 12, 2021 - 13:06 -- NOT Open Access
Author(s): 
Gao H, Bai L, Wang S, et al.
Reference: 
Nat Microbiol. 2021 May 6

The stalling global progress in the fight against malaria prompts the urgent need to develop new intervention strategies. Whilst engineered symbiotic bacteria have been shown to confer mosquito resistance to parasite infection, a major challenge for field implementation is to address regulatory concerns. Here, we report the identification of a Plasmodium-blocking symbiotic bacterium, Serratia ureilytica Su_YN1, isolated from the midgut of wild Anopheles sinensis in China that inhibits malaria parasites via secretion of an antimalarial lipase.

Dual RNA Sequencing Meta-analysis in Plasmodium Infection Identifies Host-Parasite Interactions

April 22, 2021 - 08:37 -- Open Access
Author(s): 
Mukherjee P, Burgio G, Heitlinger E
Reference: 
mSystems. 2021 Apr 20;6(2):e00182-21

Dual RNA sequencing (RNA-Seq) is the simultaneous transcriptomic analysis of interacting symbionts, for example, in malaria. Potential cross-species interactions identified by correlated gene expression might highlight interlinked signaling, metabolic, or gene regulatory pathways in addition to physically interacting proteins. Often, malaria studies address one of the interacting organisms-host or parasite-rendering the other "contamination." Here we perform a meta-analysis using such studies for cross-species expression analysis. We screened experiments for gene expression from host and Plasmodium.

Plasmodium infection prevents recurrence and metastasis of hepatocellular carcinoma possibly via inhibition of the epithelial-mesenchymal transition

April 14, 2021 - 08:14 -- Open Access
Author(s): 
Liang Y, Chen X, Zhang X, et al.
Reference: 
Mol Med Rep. 2021 Jun;23(6):418

Postoperative recurrence causes a high mortality rate among patients with hepatocellular carcinoma (HCC). The current study aimed to determine the effects of Plasmodium infection on HCC metastasis and recurrence. The antitumor effects of Plasmodium infection were determined using two murine orthotopic HCC models: The non‑resection model and the resection model.

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