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plasmodium infection

Not Open Access | Flagging performance of Sysmex XN-10 haematology analyser for malaria detection

October 7, 2020 - 16:20 -- NOT Open Access
Author(s): 
Dumas C, Tirard-Collet P, Mestrallet F, Girard S, Jallades L, Picot S, Bienvenu AL.
Reference: 
J Clin Pathol. 2020 Oct;73(10):676-677

The aim was to assess the flagging performance of Sysmex XN-10 haematology analyser for malaria detection through the parasitic red blood cell ('pRBC') alarm.

Melatonin action in Plasmodium infection: Searching for molecules that modulate the asexual cycle as a strategy to impair the parasite cycle

October 7, 2020 - 16:04 -- Open Access
Author(s): 
Pereira PHS, Garcia CRS
Reference: 
J Pineal Res. 2020 Oct 6:e12700

Half of the world's population lives in countries at risk of malaria infection, which results in approximately 450,000 deaths annually. Malaria parasites infect erythrocytes in a coordinated manner, with cycle durations in multiples of 24 hours, which reflects a behavior consistent with the host's circadian cycle. Interference in cycle coordination can help the immune system to naturally fight infection.

A Sweet Galactose Transfer: Metabolic Oligosaccharide Engineering as a Tool To Study Glycans in Plasmodium Infection

September 17, 2020 - 13:49 -- Open Access
Author(s): 
Kitowski A, Bernardes GJL
Reference: 
Chembiochem. 2020 Sep 14;21(18):2696-2700

The introduction of chemical reporter groups into glycan structures through metabolic oligosaccharide engineering (MOE) followed by bio-orthogonal ligation is an important tool to study glycosylation. We show the incorporation of synthetic galactose derivatives that bear terminal alkene groups in hepatic cells, with and without infection by Plasmodium berghei parasites, the causative agent of malaria.

Point prevalence of asymptomatic Plasmodium infection and the comparison of microscopy, rapid diagnostic test and nested PCR for the diagnosis of asymptomatic malaria among children under 5 years in Ghana

July 28, 2020 - 14:06 -- Open Access
Author(s): 
Okyere B, Owusu-Ofori A, Dickerson T, et al.
Reference: 
PLoS ONE 15(7): e0232874

Plasmodium infection among children is a serious public health problem. Asymptomatic malaria infection among humans serves as a significant reservoir for transmitting Plasmodium to uninfected Anopheles mosquitoes, fueling malaria endemicity and asymptomatic malaria may progress to clinical malaria. Therefore, prompt and accurate diagnosis of malaria infection is crucial for the management and control of malaria, especially in endemic areas. This study assessed the point prevalence of asymptomatic malaria infection and evaluated the performance of malaria Rapid Diagnostic Tests (RDT), light microscopy and nested PCR (nPCR) for the diagnosis of asymptomatic malaria infection in a paediatric population in the Atwima Nwabiagya North district, Ghana.

Prediction of malaria transmission drivers in Anopheles mosquitoes using artificial intelligence coupled to MALDI-TOF mass spectrometry

July 13, 2020 - 16:42 -- Open Access
Author(s): 
Nabet C, Chaline A, Franetich JF, Brossas JY, Shahmirian N, Silvie O, Tannier X, Piarroux R
Reference: 
Sci Rep. 2020 Jul 9;10(1):11379

Vector control programmes are a strategic priority in the fight against malaria. However, vector control interventions require rigorous monitoring. Entomological tools for characterizing malaria transmission drivers are limited and are difficult to establish in the field. To predict Anopheles drivers of malaria transmission, such as mosquito age, blood feeding and Plasmodium infection, we evaluated artificial neural networks (ANNs) coupled to matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) and analysed the impact on the proteome of laboratory-reared Anopheles stephensi mosquitoes.

NOT Open Access | Species Composition of Anopheles (Diptera: Culicidae) in Selected Forested Tourist Areas of Nigeria Endemic for Malaria

June 23, 2020 - 15:22 -- NOT Open Access
Author(s): 
Oduwole OA, Oringanje CM, Oduola AO, Nwachuku NS, Meremikwu MM, Alaribe AAA
Reference: 
J Med Entomol. 2020 Jun 19:tjaa110

The study was carried out to determine relative abundance, species diversity, of Anopheles species (Diptera: Culicidae) in selected forested areas in Cross River State, Nigeria and the prevalence of malaria infection in the specimens. Mosquitoes were collected using pyrethrum spray catch and Centre for Disease Control light traps modified with yeast and sugar to generate carbon dioxide (CO2) and identified using morphological identification keys. We used a multiplex polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) to simultaneously distinguish sibling species of the An. gambiae s.l, including separation of An. gambiae s.s. and An. coluzzii (Diptera: Culicidae).

A sweet galactose transfer - Metabolic oligosaccharide engineering as a tool to study glycans in Plasmodium infection

April 15, 2020 - 14:28 -- Open Access
Author(s): 
Kitowski A, Bernardes GJL
Reference: 
Chembiochem. 2020 Apr 14

The introduction of chemical reporter groups in glycan structures through metabolic oligosaccharide engineering (MOE) followed by bio‐orthogonal ligation is an important tool to study glycosylation. We show the incorporation of synthetic galactose derivatives that bear terminal alkene groups in hepatic cells, with and without infection by Plasmodium berghei parasites, the causative agent of malaria.

Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection

March 30, 2020 - 10:04 -- Open Access
Author(s): 
Rogers KJ, Shtanko O, Vijay R, Mallinger LN, Joyner CJ, Galinski MR, Butler NS, Maury W
Reference: 
Cell Rep. 2020 Mar 24;30(12):4041-4051.e4

During the 2013–2016 Ebola virus (EBOV) epidemic, a significant number of patients admitted to Ebola treatment units were co-infected with Plasmodium falciparum, a predominant agent of malaria. However, there is no consensus on how malaria impacts EBOV infection. The effect of acute Plasmodium infection on EBOV challenge was investigated using mouse-adapted EBOV and a biosafety level 2 (BSL-2) model virus.

NOT Open Access | B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection

February 17, 2020 - 12:05 -- NOT Open Access
Author(s): 
Arroyo EN, Pepper M
Reference: 
J Exp Med. 2020 Feb 3;217(2). pii: e20190849

CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression.

Correction to: Occurrence and seasonal variation of human Plasmodium infection in Punjab Province, Pakistan

January 14, 2020 - 10:21 -- Open Access
Author(s): 
Qureshi NA, Fatima H, Afzal M, Khattak AA, Nawaz MA
Reference: 
BMC Infect Dis. 2020 Jan 8; 20(1):25

After publication of the original article [1], we were notified that an author’s name has been erroneously spelled. Aamir Ali Khattak should be replaced with Aamer Ali Khattak.

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