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artemisinin resistance

CRIMALDDI: a prioritized research agenda to expedite the discovery of new anti-malarial drugs

November 14, 2013 - 09:53 -- Open Access
Author(s): 
Ward SA, Boulton IC
Reference: 
Malaria Journal 2013, 12 :395 (5 November 2013)
MalariaWorld

The CRIMALDDI Consortium has been a three-year project funded by the EU Framework Seven Programme.

Medical Treatment: 

Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia

November 14, 2013 - 07:54 -- Open Access
Author(s): 
Gosi P, Lanteri CA, Bethell D, et al.
Reference: 
Malaria Journal 2013, 12 :403 (9 November 2013)
MalariaWorld

The parasites responsible for artemisinin-resistant malaria in a clinical trial in Western Cambodia comprise the dominant clones of acute malaria infections rather than minority clones emerging during treatment.

Country: 

Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor mu-chain suggests involvement of endocytosis and membrane protein trafficking

April 10, 2013 - 13:11 -- Open Access
Author(s): 
Henriques G, Martinelli A, Rodrigues L, Modrzynska K, Fawcett R, Houston DR, Borges ST, d¿Alessandro U, Tinto H, Karema C, Hunt P, Cravo P
Reference: 
Malaria Journal 2013, 12:118 (5 April 2013)
MalariaWorld

An increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex.

Molecular assessment of atpase6 mutations associated with artemisinin resistance among unexposed and exposed Plasmodium falciparum clinical isolates to artemisinin-based combination therapy

November 13, 2012 - 11:19 -- Open Access
Author(s): 
Zakeri S, Hemati S, Pirahmadi S, Afsharpad M, Raeisi A, Djadid ND
Reference: 
Malaria Journal 2012, 11:373 (9 November 2012)
MalariaWorld

Taken together, the results suggest, in particular, that pfatpase6 S769N gene needs more consideration for its possible association with artesunate resistance among P. falciparum isolates.

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