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artemisinin resistance

Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions

July 17, 2015 - 10:39 -- Open Access
Philippe Guyant, Vincent Corbel, Nicholas White, et al.
Malaria Journal 2015, 14:279 (17 July 2015)

This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to artemisinin and artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) and in Africa; access to treatment for most at risk and hard to reach population; insecticide resistance, residual and outdoors transmission.


Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012-2013

December 15, 2014 - 12:33 -- Open Access
Marylin Torrentino-Madamet, Bécaye Fall, Bruno Pradines, et al.
Malaria Journal 2014, 13:472 (4 December 2014)

The present data do not suggest widespread artemisinin resistance in Dakar in 2012-2013.

CRIMALDDI: a prioritized research agenda to expedite the discovery of new anti-malarial drugs

November 14, 2013 - 09:53 -- Open Access
Ward SA, Boulton IC
Malaria Journal 2013, 12 :395 (5 November 2013)

The CRIMALDDI Consortium has been a three-year project funded by the EU Framework Seven Programme.

Medical Treatment: 

Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia

November 14, 2013 - 07:54 -- Open Access
Gosi P, Lanteri CA, Bethell D, et al.
Malaria Journal 2013, 12 :403 (9 November 2013)

The parasites responsible for artemisinin-resistant malaria in a clinical trial in Western Cambodia comprise the dominant clones of acute malaria infections rather than minority clones emerging during treatment.


Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor mu-chain suggests involvement of endocytosis and membrane protein trafficking

April 10, 2013 - 13:11 -- Open Access
Henriques G, Martinelli A, Rodrigues L, Modrzynska K, Fawcett R, Houston DR, Borges ST, d¿Alessandro U, Tinto H, Karema C, Hunt P, Cravo P
Malaria Journal 2013, 12:118 (5 April 2013)

An increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex.

Molecular assessment of atpase6 mutations associated with artemisinin resistance among unexposed and exposed Plasmodium falciparum clinical isolates to artemisinin-based combination therapy

November 13, 2012 - 11:19 -- Open Access
Zakeri S, Hemati S, Pirahmadi S, Afsharpad M, Raeisi A, Djadid ND
Malaria Journal 2012, 11:373 (9 November 2012)

Taken together, the results suggest, in particular, that pfatpase6 S769N gene needs more consideration for its possible association with artesunate resistance among P. falciparum isolates.


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