The CRIMALDDI Consortium has been a three-year project funded by the EU Framework Seven Programme.
The parasites responsible for artemisinin-resistant malaria in a clinical trial in Western Cambodia comprise the dominant clones of acute malaria infections rather than minority clones emerging during treatment.
Resistance to artemisinin casts a shadow on the fight against malaria.
An increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex.
Taken together, the results suggest, in particular, that pfatpase6 S769N gene needs more consideration for its possible association with artesunate resistance among P. falciparum isolates.