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artemisinin resistance

Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles

July 11, 2017 - 12:50 -- Open Access
Author(s): 
Kevin C. Kobylinski, Ratawan Ubalee, Jason H. Richardson, et al.
Reference: 
Malaria Journal 2017 16:280, 7 July 2017

Ivermectin is lethal to dominant GMS Anopheles malaria vectors and inhibits sporogony of P. vivax at safe human relevant concentrations.

NOT Open Access | Molecular Profile of Malaria Drug Resistance Markers of Plasmodium falciparum in Suriname

June 27, 2017 - 17:57 -- NOT Open Access
Author(s): 
Stella M. Chenet, Sheila Akinyi Okoth, Malti R. Adhin, et al.
Reference: 
Antimicrob. Agents Chemother. July 2017 vol. 61 no. 7 e02655-16

In Suriname, an artesunate monotherapy therapeutic efficacy trial was recently conducted to evaluate partial artemisinin resistance emerging in Plasmodium falciparum.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

October 6, 2016 - 17:21 -- Open Access
Author(s): 
Amélie Le Bihan, Ruben de Kanter, Sergio Wittlin, et al.
Reference: 
PLoS Med 13(10): e1002138

The dual activity of ACT-451840 against asexual and sexual stages of P. falciparum and the activity on P. vivax have the potential to meet the specific profile of a target compound that could replace the fast-acting artemisinin component and harbor additional gametocytocidal activity and, thereby, transmission-blocking properties.

Medical Treatment: 

Plasmodium falciparum parasite population structure and gene flow associated to anti-malarial drugs resistance in Cambodia

June 16, 2016 - 16:14 -- Open Access
Author(s): 
Ankit Dwivedi, Nimol Khim, Emmanuel Cornillot, et al.
Reference: 
Malaria Journal 2016 15:319, 14 June 2016

The gene flow between these subpopulations might have driven the spread of artemisinin resistance over Cambodia.

Country: 

Prevalence of Plasmodium spp. in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir

June 13, 2016 - 16:21 -- Open Access
Author(s): 
Maylis Douine, Lise Musset, Mathieu Nacher, et al.
Reference: 
Malaria Journal 2016 15:315, 9 June 2016

This significant malaria reservoir in a mobile and illegal population with difficult access to a health care system raises the threat of artemisinin resistance and puts the population of the Guiana Shield at risk of new transmission foci while countries of the region aim at malaria elimination.

Country: 

Challenges encountered by local health volunteers in early diagnosis and prompt treatment of malaria in Myanmar artemisinin resistance containment zones

June 6, 2016 - 17:44 -- Open Access
Author(s): 
Myat Htut Nyunt, Khin Myo Aye, Khin Thiri Kyaw, Soe Soe Han, Thin Thin Aye, Khin Thet Wai and Myat Phone Kyaw
Reference: 
Malaria Journal 2016 15:308, 6 June 2016

Adequate refresher training, monitoring, supervision, and regular reliable supply of RDTs and anti-malarials were needed for capacity strengthening of volunteers in MARC zones.

Village malaria worker performance key to the elimination of artemisinin-resistant malaria: a Western Cambodia health system assessment

May 24, 2016 - 16:26 -- Open Access
Author(s): 
Sara E. Canavati, Saranath Lawpoolsri, Maxine Anne Whittaker, et al.
Reference: 
Malaria Journal 2016 15:282, 20 May 2016

VMW/MMW job performance must be increased from 80 to 100 % in order to achieve elimination.

Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria

May 11, 2016 - 16:14 -- Open Access
Author(s): 
Neda Moradin, Sabrina Torre, Susan Gauthier, Mifong Tam, Jalal Hawari, Kirsten Vandercruyssen, Bart De Spiegeleer, Anny Fortin, Mary M. Stevenson and Philippe Gros
Reference: 
Malaria Journal 2016 15:260, 6 May 2016

These findings indicate that inclusion of Cys in current formulations of ACT, or its use as adjunct therapy could improve the anti-plasmodial activity of artemisinin, decrease mortality in cerebral malaria patients, and prevent or delay the development and spread of artemisinin resistance.

Medical Treatment: 

Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study

April 2, 2016 - 16:17 -- Open Access
Author(s): 
Kyaw Myo Tun, Atthanee Jeeyapant, Nicholas P. J. Day, et al.
Reference: 
Malaria Journal 2016 15:185, 31 March 2016

The dominant k13 mutation observed in Upper Myanmar, F446I, appears to be associated with an intermediate rate of parasite clearance compared to other common mutations described elsewhere in the Greater Mekong Subregion.

Country: 

Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan Africa

January 12, 2016 - 16:52 -- Open Access
Author(s): 
Hannah Slater, Jamie Griffin, Azra Ghani, Lucy Okell
Reference: 
Malaria Journal 2016, 15:10 (6 January 2016)

Artemisinin resistance is potentially a more pressing concern than partner drug resistance due to the lack of viable alternatives.

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