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artemisinin resistance

Challenges encountered by local health volunteers in early diagnosis and prompt treatment of malaria in Myanmar artemisinin resistance containment zones

June 6, 2016 - 17:44 -- Open Access
Myat Htut Nyunt, Khin Myo Aye, Khin Thiri Kyaw, Soe Soe Han, Thin Thin Aye, Khin Thet Wai and Myat Phone Kyaw
Malaria Journal 2016 15:308, 6 June 2016

Adequate refresher training, monitoring, supervision, and regular reliable supply of RDTs and anti-malarials were needed for capacity strengthening of volunteers in MARC zones.

Village malaria worker performance key to the elimination of artemisinin-resistant malaria: a Western Cambodia health system assessment

May 24, 2016 - 16:26 -- Open Access
Sara E. Canavati, Saranath Lawpoolsri, Maxine Anne Whittaker, et al.
Malaria Journal 2016 15:282, 20 May 2016

VMW/MMW job performance must be increased from 80 to 100 % in order to achieve elimination.

Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria

May 11, 2016 - 16:14 -- Open Access
Neda Moradin, Sabrina Torre, Susan Gauthier, Mifong Tam, Jalal Hawari, Kirsten Vandercruyssen, Bart De Spiegeleer, Anny Fortin, Mary M. Stevenson and Philippe Gros
Malaria Journal 2016 15:260, 6 May 2016

These findings indicate that inclusion of Cys in current formulations of ACT, or its use as adjunct therapy could improve the anti-plasmodial activity of artemisinin, decrease mortality in cerebral malaria patients, and prevent or delay the development and spread of artemisinin resistance.

Medical Treatment: 

Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study

April 2, 2016 - 16:17 -- Open Access
Kyaw Myo Tun, Atthanee Jeeyapant, Nicholas P. J. Day, et al.
Malaria Journal 2016 15:185, 31 March 2016

The dominant k13 mutation observed in Upper Myanmar, F446I, appears to be associated with an intermediate rate of parasite clearance compared to other common mutations described elsewhere in the Greater Mekong Subregion.


Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan Africa

January 12, 2016 - 16:52 -- Open Access
Hannah Slater, Jamie Griffin, Azra Ghani, Lucy Okell
Malaria Journal 2016, 15:10 (6 January 2016)

Artemisinin resistance is potentially a more pressing concern than partner drug resistance due to the lack of viable alternatives.

Evaluation of the behaviour change communication and community mobilization activities in Myanmar artemisinin resistance containment zones

January 2, 2016 - 18:38 -- Open Access
Myat Nyunt, Khin Aye, Kyaw San, et al.
Malaria Journal 2015, 14:522 (23 December 2015)

Efforts should focus on correcting misconceptions about malaria transmission, prevention and universal use of ITN/LLINs.

Medical Treatment: 

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis

September 23, 2015 - 16:44 -- Open Access
WWARN Parasite Clearance Study Group
Malaria Journal 2015, 14:359 (22 September 2015)

Several factors affect PC 1/2 . As substantial heterogeneity in parasite clearance exists between locations, early detection of artemisinin resistance requires reference PC 1/2 data.

NOT Open Access | Understanding artemisinin-resistant malaria: what a difference a year makes

September 3, 2015 - 14:42 -- NOT Open Access
Fairhurst, Rick M.
Current Opinion in Infectious Diseases:, October 2015 - Volume 28 - Issue 5 - p 417–425

In SEA, clinical and epidemiological investigations are urgently needed to stop the further spread of artemisinin resistance, monitor the efficacy of ACTs where K13 mutations are prevalent, identify currently-available drug regimens that cure ACT failures, and rapidly advance new antimalarial compounds through preclinical studies and clinical trials.

Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions

July 17, 2015 - 10:39 -- Open Access
Philippe Guyant, Vincent Corbel, Nicholas White, et al.
Malaria Journal 2015, 14:279 (17 July 2015)

This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to artemisinin and artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) and in Africa; access to treatment for most at risk and hard to reach population; insecticide resistance, residual and outdoors transmission.


Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012-2013

December 15, 2014 - 12:33 -- Open Access
Marylin Torrentino-Madamet, Bécaye Fall, Bruno Pradines, et al.
Malaria Journal 2014, 13:472 (4 December 2014)

The present data do not suggest widespread artemisinin resistance in Dakar in 2012-2013.


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