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Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification

February 23, 2021 - 12:50 -- Open Access
Ekasari W, Basuki DR, Arwati H, Wahyuni TS
BMC Complement Med Ther. 2021 Feb 19;21(1):71

In previous studies, Cassia spectabilis DC leaf has shown a good antiplasmodial activity. Therefore, this study is a follow-up study of the extract of leaf of C. spectabilis DC on its in vitro and in vivo antiplasmodial activity and mechanism as an antimalarial.

NOT Open Access | Screening the Pathogen Box for Molecules Active against Plasmodium Sexual Stages Using a New Nanoluciferase-Based Transgenic Line of P. berghei Identifies Transmission-Blocking Compounds

October 30, 2018 - 12:45 -- NOT Open Access
Juliana Calit, Irina Dobrescu, Xiomara A. Gaitán, Miriam H. Borges, Marisé S. Ramos, Richard T. Eastman and Daniel Y. Bargieri
Antimicrob. Agents Chemother. November 2018 62:e01053-18

Malaria remains an important parasitic disease with a large morbidity and mortality burden.

Generation of transgenic rodent malaria parasites by transfection of cell culture-derived merozoites

August 3, 2017 - 15:13 -- Open Access
Gesine Kaiser, Mariana De Niz, Paul-Christian Burda, Livia Niklaus, Rebecca Limenitakis Stanway and Volker Heussler
Malaria Journal 2017 16:305, 1 August 2017

An alternative protocol for Plasmodium transfection is hereby provided, which uses liver stage-derived P. berghei merozoites for transfection.

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria

August 12, 2015 - 13:25 -- Open Access
Cynthia H Val, Fátima Brant, Fabiana S Machado, et al.
Malaria Journal 2015, 14:311 (11 August 2015)

This study strongly suggests that the administration of A. blazei (aqueous extract or fraction C) was effective in improving the consequences of CM in mice and may provide novel therapeutic strategies.

NOT Open Access | Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

July 30, 2014 - 06:37 -- NOT Open Access
Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Bioorganic & Medicinal Chemistry, Volume 22, Issue 15, 1 August 2014, Pages 3887–3890

Sixteen triterpenoids (1–16), previously isolated from the aerial parts of the African medicinal plant Momordica balsamina or obtained by derivatization, were evaluated for their activity against liver stages of Plasmodium berghei, measuring the luminescence intensity in Huh-7 cells infected with a firefly luciferase-expressing P. berghei line, PbGFP-Luccon.

Spatiotemporal and Functional Characterisation of the Plasmodium falciparum cGMP-Dependent Protein Kinase

November 13, 2012 - 11:16 -- Open Access
Christine S. Hopp, Christian Flueck, Lev Solyakov, Andrew Tobin, David A. Baker
PLoS ONE 7(11): e48206

Signalling by 3′–5′-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes.

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