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Plasmodium vivax

NOT Open Access | Exposure to Plasmodium vivax is associated with the increased expression of exhaustion markers on γδ T lymphocytes

December 5, 2018 - 16:32 -- NOT Open Access
Dimpu Gogoi, Dipankar Biswas, Biswajyoti Borkakoty, Jagadish Mahanta
Parasite Immunology Volume40, Issue12 December 2018 e12594

Gamma delta (γδ) T cells exhibit potent anti‐Plasmodium activity but are also implicated in the immunopathology of malaria.

NOT Open Access | New Evidence for Hypnozoite-Independent Plasmodium vivax Malarial Recurrences

December 5, 2018 - 16:01 -- NOT Open Access
Miles B. Markus
Trends in Parasitology Volume 34, Issue 12, P1015-1016, December 01, 2018

Information provided in recent, related papers has wide-ranging implications concerning, inter alia, the transmission of malaria, drug treatment, and eradication of the disease.

Molecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria

December 4, 2018 - 14:32 -- Open Access
Mary Aigbiremo Oboh, Aida Sadikh Badiane, Godwin Ntadom, Yaye Die Ndiaye, Khadim Diongue, Mamadou Alpha Diallo and Daouda Ndiaye
Malaria Journal 2018 17:439, 28 November 2018

The present study gave the first molecular evidence of P. vivax in Nigeria in Duffy negative individuals.

Blood-stage Plasmodium vivax antibody dynamics in a low transmission setting: A nine year follow-up study in the Amazon region

November 21, 2018 - 15:30 -- Open Access
Camilla V. Pires, Jessica R. S. Alves, Luzia H. Carvalho, et al.
PLoS ONE 13(11): e0207244

Plasmodium vivax remains a global health problem and its ability to cause relapses and subpatent infections challenge control and elimination strategies.

Use of anthropophilic culicid-based xenosurveillance as a proxy for Plasmodium vivax malaria burden and transmission hotspots identification

November 21, 2018 - 15:28 -- Open Access
Joabi Nascimento, Vanderson S. Sampaio, Wuelton M. Monteiro, et al.
PLoS Negl Trop Dis 12(11): e0006909

Vector-borne diseases account for more than 17% of all infectious diseases, causing more than one million deaths annually.

Functional Conservation of P48/45 Proteins in the Transmission Stages of Plasmodium vivax (Human Malaria Parasite) and P. berghei (Murine Malaria Parasite)

November 21, 2018 - 15:21 -- Open Access
Yi Cao, Robert J. Hart, Geetha P. Bansal and Nirbhay Kumar
mBio September/October 2018 9:e01627-18

Sexual-stage proteins have a distinct function in the mosquito vector during transmission and also represent targets for the development of malaria transmission-blocking vaccine.

Severe Plasmodium vivax malaria, HIV, tuberculosis co-infection in a Sri Lankan traveller: case management and challenges during the prevention of malaria reintroduction phase

November 20, 2018 - 14:52 -- Open Access
Dewanee Ranaweera, R. M. J. Kanchana Rajapaksha, Priyanganie Silva, Raja Hettiarachchi, W. M. Kumudu T. de A. W. Gunasekera, Hemantha Herath and Deepika Fernando
Malaria Journal 2018 17:429, 16 November 2018

It is important to consider comorbid conditions and immunosuppression when a patient with a benign form of malaria presents with severe manifestations.


Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study

November 20, 2018 - 14:47 -- Open Access
Kanokpich Puaprasert, Cindy Chu, Naowarat Saralamba, Nicholas P. J. Day, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong
Malaria Journal 2018 17:427, 15 November 2018

The newly developed ASO assay is a reliable and rapid tool for large-scale CYP2D6 genotyping.

Specificity of the IgG antibody response to Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale MSP119 subunit proteins in multiplexed serologic assays

November 15, 2018 - 15:07 -- Open Access
Jeffrey W. Priest, Mateusz M. Plucinski, Curtis S. Huber, Eric Rogier, Bunsoth Mao, Christopher J. Gregory, Baltazar Candrinho, James Colborn and John W. Barnwell
Malaria Journal 2018 17:417

A pan-malaria MSP119 cross-reactive antibody response was observed in elutions of blood spots from two 20–30 years old Mozambique donors. The antibody response from one of these two donors had low avidity and skewed almost entirely to the IgG3 subclass.

G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients

November 15, 2018 - 15:00 -- Open Access
Sara Avalos, Rosa E. Mejia, Gustavo Fontecha, et al.
Malaria Journal 2018 17:415

The findings support that the intake of PQ during 14 days of treatment against vivax malaria is safe in patients with a class III variant of G6PDd. In view of the new national regulations in the shortened treatment of vivax malaria for 7 days, it is advisable to be alert of potential cases of severe haemolysis that could occur among G6PD deficient hemizygous males with a class II mutation such as the Santamaria variant, previously reported in the country.


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