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Plasmodium vivax

Plasmodium knowlesi as a model system for characterising Plasmodium vivax drug resistance candidate genes

June 11, 2019 - 15:08 -- Open Access
Author(s): 
Lisa H. Verzier, Rachael Coyle, Shivani Singh, Theo Sanderson, Julian C. Rayner
Reference: 
PLoS Negl Trop Dis 13(6): e0007470

Plasmodium vivax causes the majority of malaria outside Africa, but is poorly understood at a cellular level partly due to technical difficulties in maintaining it in in vitro culture conditions.

The acquisition of long-lived memory B cell responses to merozoite surface protein-8 in individuals with Plasmodium vivax infection

June 3, 2019 - 15:22 -- Open Access
Author(s): 
Piyawan Kochayoo, Natthapon Kittisenachai, Siriruk Changrob, Kittikorn Wangriatisak, Fauzi Muh, Patchanee Chootong and Eun-Taek Han
Reference: 
Malaria Journal 2019 18:188, 31 May 2019

The ability of a malaria antigen to induce effective, long-lasting immune responses is important for the development of a protective malaria vaccine. Plasmodium vivax merozoite surface protein-8 (PvMSP8) has been shown to be immunogenic in natural P. vivax infections and produces both cell-mediated and antibody-mediated immunity. Thus, PvMSP8 has been proposed as a vaccine candidate following fusion with other merozoite antigens in blood stage vaccine design. Here, the long-term responses of antibodies and memory B cells (MBCs) specific to PvMSP8 in individuals were monitored in a longitudinal cohort study.

Malaria impact on cognitive function of children in a peri-urban community in the Brazilian Amazon

May 20, 2019 - 13:40 -- Open Access
Author(s): 
Raquel Tapajós, Daniel Castro, Maria Paula Mourão, et al.
Reference: 
Malaria Journal 2019 18:173, 16 May 2019

In Latin America, where Plasmodium vivax malaria is more prevalent, it is known that this species plays an important role in the sustainability of transmission, and can have an impact on morbidity in terms of anaemia, nutritional status, and cognitive development in children.

NOT Open Access | Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil

April 30, 2019 - 15:20 -- NOT Open Access
Author(s): 
Simone Ladeia-Andrade, Maria José Menezes, Taís Nóbrega de Sousa, Ana Carolina R. Silvino, Jaques F. de Carvalho Jr., Laís C. Salla, Odaílton A. Nery, Gladson N. P. de Melo, Rodrigo M. Corder, Priscila T. Rodrigues and Marcelo U. Ferreira
Reference: 
Antimicrob. Agents Chemother. April 2019 63:e01965-18

Emerging Plasmodium vivax resistance to chloroquine (CQ) may undermine malaria elimination efforts in South America. CQ-resistant P. vivax has been found in the major port city of Manaus but not in the main malaria hot spots across the Amazon Basin of Brazil, where CQ is routinely coadministered with primaquine (PQ) for radical cure of vivax malaria. Here we randomly assigned 204 uncomplicated vivax malaria patients from Juruá Valley, northwestern Brazil, to receive either sequential (arm 1) or concomitant (arm 2) CQ-PQ treatment.

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Ten years malaria trend at Arjo-Didessa sugar development site and its vicinity, Southwest Ethiopia: a retrospective study

April 29, 2019 - 13:11 -- Open Access
Author(s): 
Dawit Hawaria, Hallelujah Getachew, Guofa Zhong, Assalif Demissew, Kasahun Habitamu, Beka Raya, Ming-Chieh Lee, Delenasaw Yewhalaw and Guiyun Yan
Reference: 
Malaria Journal 2019 18:145, 24 April 2019

The trend analysis of malaria data from health facilities is useful for understanding dynamics of malaria epidemiology and inform for future malaria control planning. Changes in clinical malaria characteristics, like gender and age distribution are good indicators of declining malaria transmission. This study was conducted to determine the malaria trend at Arjo-Didessa sugar development site and its vicinity, southwest Ethiopia, from 2008 to 2017.

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NOT Open Access | Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein

April 23, 2019 - 13:17 -- NOT Open Access
Author(s): 
Lenore L. Carias, Sebastien Dechavanne, Christopher L. King, et al.
Reference: 
The Journal of Immunology Vol. 202, Issue 9 1 May 2019

Plasmodium vivax invasion of reticulocytes relies on distinct receptor-ligand interactions between the parasite and host erythrocytes.

Long-lasting insecticidal nets and indoor residual spraying may not be sufficient to eliminate malaria in a low malaria incidence area: results from a cluster randomized controlled trial in Ethiopia

April 22, 2019 - 12:33 -- Open Access
Author(s): 
Eskindir Loha, Wakgari Deressa, Bernt Lindtjørn, et al.
Reference: 
Malaria Journal 2019 18:141, 18 April 2019

The clinical malaria incidence and anaemia prevalence were similar in the four study groups.

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Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor

April 22, 2019 - 12:30 -- Open Access
Author(s): 
Nanhua Chen, Simone Dowd, Michelle L. Gatton, Alyson Auliff, Michael D. Edstein and Qin Cheng
Reference: 
Malaria Journal 2019 18:140, 18 April 2019

CYP2D6 phenotype or activity score based on the allele classification was not a major contributor to P. vivax relapse in this ADF cohort.

Hospital-derived antibody profiles of malaria patients in Southwest India

April 22, 2019 - 12:24 -- Open Access
Author(s): 
Apoorva Venkatesh, Aarti Jain, Pradipsinh K. Rathod, et al.
Reference: 
Malaria Journal 2019 18:138, 17 April 2019

Seroreactivity at a major hospital in Southwest India reveals antibody responses to P. falciparum and P. vivax in a low malaria transmission region with much migration.

Not Open Access | Transcriptome profiling of Plasmodium vivax in Saimiri monkeys identifies potential ligands for invasion

April 9, 2019 - 13:08 -- NOT Open Access
Author(s): 
Karthigayan Gunalan, Juliana M. Sá, Louis H. Miller, et al.
Reference: 
PNAS April 2, 2019 116 (14) 7053-7061

Unlike the case in Asia and Latin America, Plasmodium vivax infections are rare in sub-Saharan Africa due to the absence of the Duffy blood group antigen (Duffy antigen), the only known erythrocyte receptor for the P. vivax merozoite invasion ligand, Duffy binding protein 1 (DBP1).

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