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Plasmodium vivax

NOT Open Access | Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein

April 23, 2019 - 13:17 -- NOT Open Access
Lenore L. Carias, Sebastien Dechavanne, Christopher L. King, et al.
The Journal of Immunology Vol. 202, Issue 9 1 May 2019

Plasmodium vivax invasion of reticulocytes relies on distinct receptor-ligand interactions between the parasite and host erythrocytes.

Long-lasting insecticidal nets and indoor residual spraying may not be sufficient to eliminate malaria in a low malaria incidence area: results from a cluster randomized controlled trial in Ethiopia

April 22, 2019 - 12:33 -- Open Access
Eskindir Loha, Wakgari Deressa, Bernt Lindtjørn, et al.
Malaria Journal 2019 18:141, 18 April 2019

The clinical malaria incidence and anaemia prevalence were similar in the four study groups.

Medical Condition: 

Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor

April 22, 2019 - 12:30 -- Open Access
Nanhua Chen, Simone Dowd, Michelle L. Gatton, Alyson Auliff, Michael D. Edstein and Qin Cheng
Malaria Journal 2019 18:140, 18 April 2019

CYP2D6 phenotype or activity score based on the allele classification was not a major contributor to P. vivax relapse in this ADF cohort.

Hospital-derived antibody profiles of malaria patients in Southwest India

April 22, 2019 - 12:24 -- Open Access
Apoorva Venkatesh, Aarti Jain, Pradipsinh K. Rathod, et al.
Malaria Journal 2019 18:138, 17 April 2019

Seroreactivity at a major hospital in Southwest India reveals antibody responses to P. falciparum and P. vivax in a low malaria transmission region with much migration.

Not Open Access | Transcriptome profiling of Plasmodium vivax in Saimiri monkeys identifies potential ligands for invasion

April 9, 2019 - 13:08 -- NOT Open Access
Karthigayan Gunalan, Juliana M. Sá, Louis H. Miller, et al.
PNAS April 2, 2019 116 (14) 7053-7061

Unlike the case in Asia and Latin America, Plasmodium vivax infections are rare in sub-Saharan Africa due to the absence of the Duffy blood group antigen (Duffy antigen), the only known erythrocyte receptor for the P. vivax merozoite invasion ligand, Duffy binding protein 1 (DBP1).

Polymorphisms in Pvkelch12 and gene amplification of Pvplasmepsin4 in Plasmodium vivax from Thailand, Lao PDR and Cambodia

April 4, 2019 - 15:56 -- Open Access
Jureeporn Duanguppama, Vivek Bhakta Mathema, Mallika Imwong, et al.
Malaria Journal 2019 18:114, 2 April 2019

A novel real-time PCR-based method to assess P. vivax Pvpm4 gene amplification was developed.

Limited differentiation among Plasmodium vivax populations from the northwest and to the south Pacific Coast of Colombia: A malaria corridor?

April 2, 2019 - 11:49 -- Open Access
M. Andreína Pacheco, Kristan A. Schneider, Nora Céspedes, Sócrates Herrera, Myriam Arévalo-Herrera, Ananias A. Escalante
PLoS Negl Trop Dis 13(3): e0007310

The observed patterns in P. vivax are consistent with a “corridor” where connected endemic areas can sustain a high level of genetic diversity locally and can restore parasite-subdivided populations via migration of infected individuals even after local interventions achieved a substantial reduction of clinical cases.

Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands

March 28, 2019 - 16:34 -- Open Access
Yi Wan Quah, Andreea Waltmann, Ivo Mueller, et al.
Malaria Journal 2019 18:106, 28 March 2019

Residual malaria transmission in Ngella exhibits strong heterogeneity and is characterized by a high proportion of submicroscopic and asymptomatic P. vivax infections, alongside sporadic P. falciparum infections.


NOT Open Access | Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

March 5, 2019 - 15:58 -- NOT Open Access
Paul R. Gilson, William Nguyen, Brad E. Sleebs, et al.
Antimicrob. Agents Chemother. February 2019 63:e01804-18

A series of 4-amino 2-anilinoquinazolines optimized for activity against the most lethal malaria parasite of humans, Plasmodium falciparum, was evaluated for activity against other human Plasmodium parasites and related apicomplexans that infect humans and animals.

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria

March 5, 2019 - 15:55 -- Open Access
Wen-Qiang He, Ahmad Rushdi Shakri, Ivo Mueller, et al.
PLoS Negl Trop Dis 13(2): e0006987

Antibodies to the key parasite invasion ligands PvDBPII and PvEBPII are good correlates of protection against P. vivax malaria in PNG


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