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An assessment of the knowledge, practices and resources during the delivery of malaria health care services among private health care practitioners: a cross section study in the Mid-Western Region of Uganda

August 17, 2021 - 15:31 -- Open Access
Wanzira H, Tumwine D, Bukoma P, Musiime A, Biculu J, Ediamu T, Gudoi S, Tibenderana JK, Mulebeke R, Nantanda R, Achan J
BMC Health Serv Res. 2021 Aug 10;21(1):788

Approximately 50 % of the population in Uganda seeks health care from private facilities but there is limited data on the quality of care for malaria in these facilities. This study aimed to document the knowledge, practices and resources during the delivery of malaria care services, among private health practitioners in the Mid-Western region of Uganda, an area of moderate malaria transmission.

NOT Open Access | Antimalarial drug discovery: from quinine to the most recent promising clinical drug candidates

August 11, 2021 - 14:55 -- NOT Open Access
Tisnerat C, Dassonville-Klimpt A, Gosselet F, Sonnet P
Curr Med Chem. 2021 Aug 3

Malaria is a tropical threatening disease caused by Plasmodium parasites, resulting in 409,000 deaths in 2019. The delay of mortality and morbidity has been compounded by the widespread of drug resistant parasites from Southeast Asia since two decades. The emergence of artemisinin-resistant Plasmodium in Africa, where most cases are accounted, highlights the urgent need for new medicines.

Quality of care for adult in-patients with malaria in a tertiary hospital in Uganda

April 14, 2021 - 07:52 -- Open Access
Ronald Kiguba, Charles Karamagi and Sheila M. Bird
Malaria Journal 2021 20:178, 9 April 2021

Prompt detection and appropriate treatment of malaria prevents severe disease and death. The quality of care for adult malaria in-patients is not well documented in sub-Saharan Africa, particularly in Uganda. The study sought to describe the patterns of malaria diagnosis and treatment among adult in-patients admitted to the medical and gynaecological wards of Uganda’s 1790-bed Mulago National Referral Hospital from December 2013 to April 2014.

Health systems readiness and quality of inpatient malaria case-management in Kano State, Nigeria

November 4, 2020 - 09:55 -- Open Access
Abiodun A. Ojo, Kolawole Maxwell, Dejan Zurovac, et al.
Malaria Journal 2020 19:384, 30 October 2020

Nigeria was among the first African countries to adopt and implement change of treatment policy for severe malaria from quinine to artesunate. Seven years after the policy change health systems readiness and quality of inpatient malaria case-management practices were evaluated in Kano State of Nigeria.

Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis

August 3, 2020 - 16:31 -- Open Access
Saito M, Mansoor R, Kennon K, Guérin PJ, et al.
Lancet Infect Dis. 2020 Aug;20(8):943-952

Malaria in pregnancy affects both the mother and the fetus. However, evidence supporting treatment guidelines for uncomplicated (including asymptomatic) falciparum malaria in pregnant women is scarce and assessed in varied ways. We did a systematic literature review and individual patient data (IPD) meta-analysis to compare the efficacy and tolerability of different artemisinin-based or quinine-based treatments for malaria in pregnant women.

Post-malarial anaemia in Mozambican children treated with quinine or artesunate: a retrospective observational study

June 8, 2020 - 15:02 -- Open Access
Varo R, Quintó L, Bassat Q, et al.
Int J Infect Dis. 2020 Jun 1:S1201-9712(20)30396-9

This retrospective analysis performed in Manhiça, Southern Mozambique aimed to describe the occurrence of post-malarial anaemia (measured as a decrease of haematocrit ≥10%) and the need for blood transfusions in children with severe malaria treated with intravenous quinine or parenteral artesunate.

Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

June 2, 2020 - 13:57 -- Open Access
Saito M, Mansoor R, Guérin PJ, et al.
BMC Med. 2020 Jun 2; 18(1):138

Malaria in pregnancy, including asymptomatic infection, has a detrimental impact on foetal development. Individual patient data (IPD) meta-analysis was conducted to compare the association between antimalarial treatments and adverse pregnancy outcomes, including placental malaria, accompanied with the gestational age at diagnosis of uncomplicated falciparum malaria infection.

NOT Open Access | Acquired auditory neuropathy spectrum disorder after malaria treated with quinine

April 18, 2020 - 13:50 -- NOT Open Access
Brough H
Trop Doct. 2020 Apr 14:49475520917236

Auditory neuropathy spectrum disorder (ANSD) can cause significant hearing impairment; it occurs when there is intact outer hair cell function in the inner ear, with a dyssynchronous neural response, thought to be due to dysfunction of the inner hair cells (IHCs), the synapse of the IHCs and the auditory nerve, or of the auditory nerve itself.

NOT Open Access | Propensity Score Analysis of Artesunate Versus Quinine for Severe Imported Plasmodium falciparum Malaria in France

January 7, 2020 - 14:04 -- NOT Open Access
El Ket N, Kendjo E, Jauréguiberry S, et al.
Clinical Infectious Diseases, Volume 70, Issue 2, 15 January 2020, Pages 280–287

Little is known on the use of artesunate compared with quinine for the treatment of imported malaria cases in nonendemic countries with a high level of care. Therefore, we compared the 2 treatments in terms of mortality and hospital and intensive care unit (ICU) discharge rates.

Historical Review: Problematic Malaria Prophylaxis with Quinine

May 17, 2016 - 15:53 -- Open Access
G. Dennis Shanks
Am J Trop Med Hyg 16-0138

Quinine was supplied by the first global pharmaceutical cartel which discouraged competition resulting in a near monopoly of cinchona plantations on the island of Java which were closed to Allied use when the Japanese Imperial Army captured Indonesia in 1942. 


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