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Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis

August 3, 2020 - 16:31 -- Open Access
Saito M, Mansoor R, Kennon K, Guérin PJ, et al.
Lancet Infect Dis. 2020 Aug;20(8):943-952

Malaria in pregnancy affects both the mother and the fetus. However, evidence supporting treatment guidelines for uncomplicated (including asymptomatic) falciparum malaria in pregnant women is scarce and assessed in varied ways. We did a systematic literature review and individual patient data (IPD) meta-analysis to compare the efficacy and tolerability of different artemisinin-based or quinine-based treatments for malaria in pregnant women.

Post-malarial anaemia in Mozambican children treated with quinine or artesunate: a retrospective observational study

June 8, 2020 - 15:02 -- Open Access
Varo R, Quintó L, Bassat Q, et al.
Int J Infect Dis. 2020 Jun 1:S1201-9712(20)30396-9

This retrospective analysis performed in Manhiça, Southern Mozambique aimed to describe the occurrence of post-malarial anaemia (measured as a decrease of haematocrit ≥10%) and the need for blood transfusions in children with severe malaria treated with intravenous quinine or parenteral artesunate.

Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

June 2, 2020 - 13:57 -- Open Access
Saito M, Mansoor R, Guérin PJ, et al.
BMC Med. 2020 Jun 2; 18(1):138

Malaria in pregnancy, including asymptomatic infection, has a detrimental impact on foetal development. Individual patient data (IPD) meta-analysis was conducted to compare the association between antimalarial treatments and adverse pregnancy outcomes, including placental malaria, accompanied with the gestational age at diagnosis of uncomplicated falciparum malaria infection.

NOT Open Access | Acquired auditory neuropathy spectrum disorder after malaria treated with quinine

April 18, 2020 - 13:50 -- NOT Open Access
Brough H
Trop Doct. 2020 Apr 14:49475520917236

Auditory neuropathy spectrum disorder (ANSD) can cause significant hearing impairment; it occurs when there is intact outer hair cell function in the inner ear, with a dyssynchronous neural response, thought to be due to dysfunction of the inner hair cells (IHCs), the synapse of the IHCs and the auditory nerve, or of the auditory nerve itself.

NOT Open Access | Propensity Score Analysis of Artesunate Versus Quinine for Severe Imported Plasmodium falciparum Malaria in France

January 7, 2020 - 14:04 -- NOT Open Access
El Ket N, Kendjo E, Jauréguiberry S, et al.
Clinical Infectious Diseases, Volume 70, Issue 2, 15 January 2020, Pages 280–287

Little is known on the use of artesunate compared with quinine for the treatment of imported malaria cases in nonendemic countries with a high level of care. Therefore, we compared the 2 treatments in terms of mortality and hospital and intensive care unit (ICU) discharge rates.

Historical Review: Problematic Malaria Prophylaxis with Quinine

May 17, 2016 - 15:53 -- Open Access
G. Dennis Shanks
Am J Trop Med Hyg 16-0138

Quinine was supplied by the first global pharmaceutical cartel which discouraged competition resulting in a near monopoly of cinchona plantations on the island of Java which were closed to Allied use when the Japanese Imperial Army captured Indonesia in 1942. 

Not Open Access | Shifting from quinine to artesunate as first-line treatment of severe malaria in children and adults: Saving more lives

September 15, 2014 - 18:32 -- NOT Open Access
Jean Jacques N. Noubiap
Journal of Infection and Public Health, Volume 7, Issue 5, September–October 2014, Pages 407-412

This review presents a background for recommending artesunate as the first-line treatment of severe malaria in children and adults, and interventions that are recommended to accelerate access to injectable artesunate.

Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand

April 11, 2014 - 18:51 -- Open Access
Mungthin M, Intanakom S, Suwandittakul N, Suida P, Amsakul S, Sitthichot N, Thammapalo S, Leelayoova S
Malaria Journal 2014, 13 :117 (27 March 2014)

This study was conducted to compare the distribution pattern of the pfcrt and pfmdr1 polymorphisms in the parasites from the lower southern provinces, Thai-Malaysia border and the upper southern provinces, Thai-Myanmar border.

Research: Formulation of quinine suppository for initiation of early treatment of malaria – a preliminary study

December 10, 2012 - 10:04 -- Bart G.J. Knols
Rebecca O. Soremekun, Boladale O. Silva, Fola Tayo, Cecilia I. Igwilo
MWJ 2012, 3, 14

The aim of this study was to develop a quinine suppository with adequate release properties that also meets the dual conditions of affordability and ease of administration. Cocoa butter and FattibaseTM were used in the preparation of suppositories containing 200 mg quinine bisulphate. Release profiles of formulations with varying concentrations of polysorbate 80 (0 – 5%) were evaluated by in vitro dissolution in pH 8 buffer medium. Formulations with the two bases released quinine in adequate quantities for the management of malaria.

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A lactate dehydrogenase ELISA-based assay for the in vitro determination of Plasmodium berghei sensitivity to anti-malarial drugs

November 12, 2012 - 08:55 -- Open Access
Orjuela-Sánchez P, Duggan E, Nolan J, Frangos JA, Carvalho LJ
Malaria Journal 2012, 11:366 (5 November 2012)

This ELISA-based in vitro drug assay is easy to implement, fast, and avoids the use radioisotopes or expensive equipment.

Medical Treatment: 
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