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quinine

Historical Review: Problematic Malaria Prophylaxis with Quinine

May 17, 2016 - 15:53 -- Open Access
Author(s): 
G. Dennis Shanks
Reference: 
Am J Trop Med Hyg 16-0138

Quinine was supplied by the first global pharmaceutical cartel which discouraged competition resulting in a near monopoly of cinchona plantations on the island of Java which were closed to Allied use when the Japanese Imperial Army captured Indonesia in 1942. 

Not Open Access | Shifting from quinine to artesunate as first-line treatment of severe malaria in children and adults: Saving more lives

September 15, 2014 - 18:32 -- NOT Open Access
Author(s): 
Jean Jacques N. Noubiap
Reference: 
Journal of Infection and Public Health, Volume 7, Issue 5, September–October 2014, Pages 407-412

This review presents a background for recommending artesunate as the first-line treatment of severe malaria in children and adults, and interventions that are recommended to accelerate access to injectable artesunate.

Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand

April 11, 2014 - 18:51 -- Open Access
Author(s): 
Mungthin M, Intanakom S, Suwandittakul N, Suida P, Amsakul S, Sitthichot N, Thammapalo S, Leelayoova S
Reference: 
Malaria Journal 2014, 13 :117 (27 March 2014)

This study was conducted to compare the distribution pattern of the pfcrt and pfmdr1 polymorphisms in the parasites from the lower southern provinces, Thai-Malaysia border and the upper southern provinces, Thai-Myanmar border.

Research: Formulation of quinine suppository for initiation of early treatment of malaria – a preliminary study

December 10, 2012 - 10:04 -- Bart G.J. Knols
Author(s): 
Rebecca O. Soremekun, Boladale O. Silva, Fola Tayo, Cecilia I. Igwilo
Reference: 
MWJ 2012, 3, 14

The aim of this study was to develop a quinine suppository with adequate release properties that also meets the dual conditions of affordability and ease of administration. Cocoa butter and FattibaseTM were used in the preparation of suppositories containing 200 mg quinine bisulphate. Release profiles of formulations with varying concentrations of polysorbate 80 (0 – 5%) were evaluated by in vitro dissolution in pH 8 buffer medium. Formulations with the two bases released quinine in adequate quantities for the management of malaria.

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A lactate dehydrogenase ELISA-based assay for the in vitro determination of Plasmodium berghei sensitivity to anti-malarial drugs

November 12, 2012 - 08:55 -- Open Access
Author(s): 
Orjuela-Sánchez P, Duggan E, Nolan J, Frangos JA, Carvalho LJ
Reference: 
Malaria Journal 2012, 11:366 (5 November 2012)
MalariaWorld

This ELISA-based in vitro drug assay is easy to implement, fast, and avoids the use radioisotopes or expensive equipment.

Medical Treatment: 
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