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Preparations of Rectal Suppositories Containing Artesunate

March 10, 2020 - 16:05 -- Open Access
Persaud S, Eid S, Swiderski N, Serris I, Cho H
Pharmaceutics. 2020 Mar 2;12(3)

Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas. The main challenges are to improve the solubility of drugs in the rectal fluids and prevent the product from turning rancid or melting in a tropical climate.

NOT Open Access | Propensity Score Analysis of Artesunate Versus Quinine for Severe Imported Plasmodium falciparum Malaria in France

January 7, 2020 - 14:04 -- NOT Open Access
El Ket N, Kendjo E, Jauréguiberry S, et al.
Clinical Infectious Diseases, Volume 70, Issue 2, 15 January 2020, Pages 280–287

Little is known on the use of artesunate compared with quinine for the treatment of imported malaria cases in nonendemic countries with a high level of care. Therefore, we compared the 2 treatments in terms of mortality and hospital and intensive care unit (ICU) discharge rates.

Adherence to the referral advice after introduction of rectal artesunate for pre-referral treatment of severe malaria at the community level: a noninferiority trial in the Democratic Republic of the Congo

December 30, 2019 - 14:37 -- Open Access
Patrick M. Mvumbi, Jeanine Musau, Ousmane Faye, Hyppolite Situakibanza and Emile Okitolonda
Malaria Journal 2019 18:438, 21 December 2019

The Democratic Republic of the Congo adopted the strategy of using, at the community level, a dose of rectal artesunate as a pre-referral treatment for severe malaria amongst children under 5 years who could not quickly reach a health care facility and take oral medication. However, the adherence to referral advice after the integration of this strategy and the acceptability of the strategy were unknown.

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

August 15, 2017 - 16:30 -- Open Access
Drew D, Wilson D, Elliott S, Cross N, Terheggen U, Hodder A, Siba P, Chelimo K, Dent A, Kazura J, Mueller I, Beeson J
BMC Medicine 2016, 14 :144 (23 September 2016)

We found that AMA1 was a major target of naturally acquired invasion-inhibitory antibodies that were highly prevalent in malaria-endemic populations and showed a high degree of allele specificity. Significantly, the prevalence of inhibitory antibodies to different alleles varied substantially within populations and between geographic locations.

Engaging scientists: An online survey exploring the experience of innovative biotechnological approaches to controlling vector-borne diseases

September 14, 2015 - 13:07 -- Open Access
Christophe Boëte, Uli Beisel, Luísa Reis Castro, Nicolas Césard and R. Guy Reeves
Parasites & Vectors 2015, 8:414

Our results indicate that there is scope to strengthen already effective methods of communication, in addition to a strong demand by scientists (expressed by 79.9 % of respondents) to develop new, creative modes of public engagement.

Delayed-Onset Hemolytic Anemia in Patients with Travel-Associated Severe Malaria Treated with Artesunate, France, 2011–2013

April 3, 2015 - 15:46 -- Open Access
Stéphane Jauréguiberry, Marc Thellier, Eric Caumes, et al.
Emmerging Infectious Diseases Volume 21, Number 5—May 2015

We prospectively evaluated a cohort of 123 patients in France who had severe imported malaria that was treated with artesunate; our evaluation focused on outcome, adverse events, and postartesunate delayed-onset hemolysis (PADH). Of the 123 patients, 6 (5%) died. Overall, 97 adverse events occurred.

Efficacy of sulphadoxine-pyrimethamine + artesunate, sulphadoxine-pyrimethamine + amodiaquine, and sulphadoxine-pyrimethamine alone in uncomplicated falciparum malaria in Mali

March 10, 2015 - 14:01 -- Open Access
Hamma Maiga, Abdoulaye A Djimde, Ogobara K Doumbo, et al.
Malaria Journal 2015, 14:64 (7 February 2015)

Sulphadoxine-pyrimethamine + amodiaquine therapy was as efficacious as sulphadoxine-pyrimethamine + artesunate, but more efficacious than sulphadoxine-pyrimethamine alone in the treatment of uncomplicated P. falciparum malaria in Mali.

Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season

March 4, 2015 - 15:06 -- Open Access
Bécaye Fall, Cheikhou Camara, Mansour Fall, Aminata Nakoulima, Pierre Dionne, Bakary Diatta, Yaya Diemé, Boubacar Wade, Bruno Pradines
Malaria Journal 2015, 14:60 (6 February 2015)

The prevalence of isolates with a reduced susceptibility to MQ remains high and stable in Dakar. Since 2004, the prevalence of CQ resistance decreased, but rebounded in 2013 in Dakar. PND, PPQ and PVB showed high in vitro activity in P. falciparum parasites from Dakar

Not Open Access | Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

December 2, 2014 - 16:35 -- NOT Open Access
Nai-Di Yang, Shi-Hao Tan, Shukie Ng, Yin Shi, Jing Zhou, Kevin Shyong Wei Tan, Wai-Shiu Fred Wong and Han-Ming Shen
Journal of Biological Chemistry, 289, 33425-33441.

In this study, we aimed to elucidate the molecular mechanisms underlying ART-induced cell death. We first confirmed that ART induces apoptotic cell death in cancer cells. Interestingly, we found that ART preferably accumulates in the lysosomes and is able to activate lysosomal function via promotion of lysosomal V-ATPase assembly.

Not Open Access | Shifting from quinine to artesunate as first-line treatment of severe malaria in children and adults: Saving more lives

September 15, 2014 - 18:32 -- NOT Open Access
Jean Jacques N. Noubiap
Journal of Infection and Public Health, Volume 7, Issue 5, September–October 2014, Pages 407-412

This review presents a background for recommending artesunate as the first-line treatment of severe malaria in children and adults, and interventions that are recommended to accelerate access to injectable artesunate.


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