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plasmodium berghei

NOT Open Access | Dysregulation of solute carrier transporters in malaria‐infected pregnant mice

April 2, 2019 - 11:36 -- NOT Open Access
Author(s): 
Najwa Najjar, Eliza R. McColl, Andrea Weckman, Kevin C. Kain, Micheline Piquette‐Miller
Reference: 
Parasite Immunology, Volume41, Issue4 April 2019 e12614

Malaria in pregnancy significantly alters the expression of SLC transporters in maternal and foetal tissues as well as the placenta, regardless of L‐arginine supplementation.

The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes

March 20, 2019 - 15:39 -- Open Access
Author(s): 
Kevin Thiévent, Gaël Hauser, Obada Elaian and Jacob C. Koella
Reference: 
Malaria Journal 2019 18:79, 14 March 2019

The results suggest that the impact of ITNs may be weaker for malaria-infected than for uninfected mosquitoes.

Effects of Azadirachta indica seed kernel extracts on early erythrocytic schizogony of Plasmodium berghei and pro-inflammatory response in inbred mice

February 13, 2019 - 16:17 -- Open Access
Author(s): 
Annette Habluetzel, Barbara Pinto, Fabrizio Bruschi, et al.
Reference: 
Malaria Journal 2019 18:35, 8 February 2019

The effects of the ME on the parasite-host interactions appeared to be mouse strain-dependent, but also related to the ripening stage of the neem fruits, as only the unripe fruit seed kernel extracts displayed appreciable bioactivity.

Influence of midgut microbiota in Anopheles stephensi on Plasmodium berghei infections

October 30, 2018 - 15:41 -- Open Access
Author(s): 
Devaiah Monnanda Kalappa, Pradeep Annamalai Subramani, Neena Valecha, et al.
Reference: 
Malaria Journal 2018 17:385, 25 October 2018

The use of microbial symbiont to reduce the competence of vectors involved in disease transmission has gained much importance in recent years as an emerging alternative approach towards disease control.

NOT Open Access | Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice

July 19, 2018 - 16:53 -- NOT Open Access
Author(s): 
Ana Carolina Moreira Souza, Vanessa Carla Furtado Mosqueira, Ana Paula Amariz Silveira, Lidiane Rodrigues Antunes, Sylvain Richard, Homero Nogueira Guimarães, Andrea Grabe-Guimarães
Reference: 
Parasitology, Volume 145 / Issue 8, July 2018, pp 1075 – 1083

Artemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat malaria.

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection

May 31, 2018 - 15:23 -- Open Access
Author(s): 
Dora Posfai, Kayla Sylvester, Emily R. Derbyshire, et al.
Reference: 
PLoS Pathog 14(5): e1007057

Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria.

Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA

April 24, 2018 - 15:28 -- Open Access
Author(s): 
Gideon Kofi Helegbe, Nguyen Tien Huy, Tetsuo Yanagi, Mohammed Nasir Shuaibu, Mihoko Kikuchi, Mahamoud Sama Cherif and Kenji Hirayama
Reference: 
Malaria Journal 2018 17:169, 17 April 2018

In conclusion, elevated IL-17 levels together with high IL-4, IL-12α and IFN-γ levels may be a marker of protection, and the mechanism may be controlled by host factor (s).

Isobolographic analysis of co-administration of two plant-derived antiplasmodial drug candidates, cryptolepine and xylopic acid, in Plasmodium berghei

April 9, 2018 - 15:16 -- Open Access
Author(s): 
Elvis O. Ameyaw, Kodwo B. Asmah, Robert P. Biney, Isaac T. Henneh, Phyllis Owusu-Agyei, James Prah and Arnold D. Forkuo
Reference: 
Malaria Journal 2018 17:153, 4 April 2018

The co-administration of cryptolepine and xylopic acid produces synergistic anti-malarial effect with minimal toxicity.

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

November 15, 2017 - 16:08 -- Open Access
Author(s): 
Valerie M. Crowley, Kodjo Ayi, Ziyue Lu, Karen T. Liby, Michael Sporn and Kevin C. Kain
Reference: 
Malaria Journal 2017 16:463, 14 November 2017

These results indicate that SO are a new class of immunomodulatory drugs and support further studies investigating this class of agents as potential adjunctive therapy for severe malaria.

Characterization of Pb51 in Plasmodium berghei as a malaria vaccine candidate targeting both asexual erythrocytic proliferation and transmission

November 15, 2017 - 16:07 -- Open Access
Author(s): 
Jian Wang, Wenqi Zheng, Fei Liu, Yaru Wang, Yiwen He, Li Zheng, Qi Fan, Enjie Luo, Yaming Cao and Liwang Cui
Reference: 
Malaria Journal 2017 16:458, 13 November 2017

In P. berghei, P51 was expressed in both asexual erythrocytic and sexual stages and localized on the surface of these stages with the exception of the ring stage.

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