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plasmodium berghei

Essential role of GEXP15, a specific protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission

August 9, 2019 - 14:53 -- Open Access
Author(s): 
Thomas Hollin, Caroline De Witte, Aline Fréville, Ida Chiara Guerrera, Cerina Chhuon, Jean-Michel Saliou, Fabien Herbert, Christine Pierrot, Jamal Khalife
Reference: 
PLoS Pathog 15(7): e1007973

The essential and distinct functions of Protein Phosphatase type 1 (PP1) catalytic subunit in eukaryotes are exclusively achieved through its interaction with a myriad of regulatory partners.

Anti-malarial activity of the root extract of Euphorbia abyssinica (Euphorbiaceae) against Plasmodium berghei infection in mice

August 5, 2019 - 16:29 -- Open Access
Author(s): 
Abrham Belachew Muluye, Ashenafi Genanew Desta, Selamu Kebamo Abate and Gemechu Tiruneh Dano
Reference: 
Malaria Journal 2019 18:261, 30 July 2019

More than 200 medicinal plants including Euphorbia abyssinica are utilized for treatment of malaria in Ethiopian traditional medical practices. However, the safety, efficacy and quality of these medicinal plants are largely unknown. Pharmacological and toxicological investigations of these plants are among the prioritized issues in every country. The aim of this study was, therefore, to evaluate the anti-malarial activity of Euphorbia abyssinica root extract against Plasmodium berghei infection in mice.

Medical Treatment: 

Improvement of an in vitro drug selection method for generating transgenic Plasmodium berghei parasites

July 1, 2019 - 15:48 -- Open Access
Author(s): 
Akira Soga, Takahiro Shirozu, Mami Ko-ketsu and Shinya Fukumoto
Reference: 
Malaria Journal 2019 18:215, 25 June 2019

Reverse genetics approaches have become powerful tools to dissect the biology of malaria parasites. In a previous study, development of an in vitro drug selection method for generating transgenic parasite of Plasmodium berghei was reported. Using this method, two novel and independent selection markers using the P. berghei heat shock protein 70 promoter was previously established. While the approach permits the easy and flexible genetic manipulation of P. berghei, shortcomings include a low variety in promoter options to drive marker gene expression and increased complexity of the selection procedure. In this study, addressing these issues was attempted.

Medical Condition: 

NOT Open Access | Dysregulation of solute carrier transporters in malaria‐infected pregnant mice

April 2, 2019 - 11:36 -- NOT Open Access
Author(s): 
Najwa Najjar, Eliza R. McColl, Andrea Weckman, Kevin C. Kain, Micheline Piquette‐Miller
Reference: 
Parasite Immunology, Volume41, Issue4 April 2019 e12614

Malaria in pregnancy significantly alters the expression of SLC transporters in maternal and foetal tissues as well as the placenta, regardless of L‐arginine supplementation.

The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes

March 20, 2019 - 15:39 -- Open Access
Author(s): 
Kevin Thiévent, Gaël Hauser, Obada Elaian and Jacob C. Koella
Reference: 
Malaria Journal 2019 18:79, 14 March 2019

The results suggest that the impact of ITNs may be weaker for malaria-infected than for uninfected mosquitoes.

Effects of Azadirachta indica seed kernel extracts on early erythrocytic schizogony of Plasmodium berghei and pro-inflammatory response in inbred mice

February 13, 2019 - 16:17 -- Open Access
Author(s): 
Annette Habluetzel, Barbara Pinto, Fabrizio Bruschi, et al.
Reference: 
Malaria Journal 2019 18:35, 8 February 2019

The effects of the ME on the parasite-host interactions appeared to be mouse strain-dependent, but also related to the ripening stage of the neem fruits, as only the unripe fruit seed kernel extracts displayed appreciable bioactivity.

Influence of midgut microbiota in Anopheles stephensi on Plasmodium berghei infections

October 30, 2018 - 15:41 -- Open Access
Author(s): 
Devaiah Monnanda Kalappa, Pradeep Annamalai Subramani, Neena Valecha, et al.
Reference: 
Malaria Journal 2018 17:385, 25 October 2018

The use of microbial symbiont to reduce the competence of vectors involved in disease transmission has gained much importance in recent years as an emerging alternative approach towards disease control.

NOT Open Access | Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice

July 19, 2018 - 16:53 -- NOT Open Access
Author(s): 
Ana Carolina Moreira Souza, Vanessa Carla Furtado Mosqueira, Ana Paula Amariz Silveira, Lidiane Rodrigues Antunes, Sylvain Richard, Homero Nogueira Guimarães, Andrea Grabe-Guimarães
Reference: 
Parasitology, Volume 145 / Issue 8, July 2018, pp 1075 – 1083

Artemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat malaria.

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection

May 31, 2018 - 15:23 -- Open Access
Author(s): 
Dora Posfai, Kayla Sylvester, Emily R. Derbyshire, et al.
Reference: 
PLoS Pathog 14(5): e1007057

Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria.

Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA

April 24, 2018 - 15:28 -- Open Access
Author(s): 
Gideon Kofi Helegbe, Nguyen Tien Huy, Tetsuo Yanagi, Mohammed Nasir Shuaibu, Mihoko Kikuchi, Mahamoud Sama Cherif and Kenji Hirayama
Reference: 
Malaria Journal 2018 17:169, 17 April 2018

In conclusion, elevated IL-17 levels together with high IL-4, IL-12α and IFN-γ levels may be a marker of protection, and the mechanism may be controlled by host factor (s).

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