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plasmodium berghei

NOT Open Access | Effect of Brugia pahangi co-infection with Plasmodium berghei ANKA in gerbils (Meriones unguiculatus)

March 20, 2020 - 09:28 -- NOT Open Access
Junaid OQ, Vythilingam I, Khaw LT, Sivanandam S, Mahmud R
Parasitol Res. 2020 Mar 16

Malaria and lymphatic filariasis (LF) are two leading and common mosquito-borne parasitic diseases worldwide. These two diseases are co-endemic in many tropical and sub-tropical regions and are known to share vectors. The interactions between malaria and filarial parasites are poorly understood. Thus, this study aimed at establishing the interactions that occur between Brugia pahangi and Plasmodium berghei ANKA (PbA) co-infection in gerbils. Briefly, the gerbils were matched according to age, sex, and weight and grouped into filarial-only infection, PbA-only infection, co-infection, and control group.

NOT Open Access | Antimalarial activity of the aqueous extract of the latex of Aloe pirottae Berger. (Aloaceae) against Plasmodium berghei in mice

March 18, 2020 - 14:57 -- NOT Open Access
Dibessa TT, Engidawork E, Nedi T, Teklehaymanot T
J Ethnopharmacol. 2020 Mar 10:112763

In spite of worldwide efforts, malaria remains one of the most devastating illnesses in the world. The huge number of lives it takes and the resistance of malaria parasites to current drugs necessitate the search for new effective antimalarial drugs. Medicinal plants have been the major source of such drugs and A. pirottae is one of these plants used traditionally for treatment of malaria in Ethiopia.

Consequences of larval competition and exposure to permethrin for the development of the rodent malaria Plasmodium berghei in the mosquito Anopheles gambiae

March 3, 2020 - 13:07 -- Open Access
Hauser G, Thiévent K, Koella JC
Parasites & Vectors, 2020 Feb 27;13(1):107

Mosquitoes and other vectors are often exposed to sublethal doses of insecticides. Larvae can be exposed to the run-off of agricultural use, and adults can be irritated by insecticides used against them and move away before they have picked up a lethal dose. This sublethal exposure may affect the success of control of insect-borne diseases, for it may affect the competence of insects to transmit parasites, in particular if the insects are undernourished.

NOT Open Access | Combination of zingerone and dihydroartemisinin presented synergistic antimalarial activity against Plasmodium berghei infection in BALB/c mice as in vivo model

March 2, 2020 - 14:07 -- NOT Open Access
Ounjaijean S, Somsak V
Parasitology International, 20 February 2020, 102088

Malaria is a global health problem leading to the death of 435,000 cases in tropical and sub-tropical zones. Spread and emergence of increasing resistance to the antimalarial drugs are the major challenges in the control of malaria. Therefore, searching for alternative antimalarial drugs is urgently needed, and combination treatment preferred as an approach to address this. This study aimed to evaluate in vivo antimalarial activity of zingerone (ZN), and its combination with dihydroartemisinin (DHA) against Plasmodium berghei infected mice.

NOT Open Access | Potential antimalarial activity of Coccinia barteri leaf extract and solvent fractions against Plasmodium berghei infected mice

February 17, 2020 - 12:03 -- NOT Open Access
Orabueze CI, Obi E, Adesegun SA, Coker HA
Journal of Ethnopharmacology, Volume 248, 10 February 2020, 112334

Coccinia barteri (Hook. F.) is traditional used in Southeast of Nigeria in management of fever. This study aimed to evaluate the antimalarial activities of hydro-methanol crude extract and solvent fractions of Coccinia barteri leaf.

Gut microbiota is essential in PGRP-LA regulated immune protection against Plasmodium berghei infection

January 27, 2020 - 16:06 -- Open Access
Gao L, Song X, Wang J
Parasites & Vectors, 2020 Jan 6; 13(1):3.

Malaria remains to be one of the deadliest infectious diseases and imposes substantial financial and social costs in the world. Mosquitoes rely on the immune system to control parasite infection. Peptidoglycan recognition proteins (PGRPs), a family of pattern-recognition receptors (PRR), are responsible for initiating and regulating immune signaling pathways. PGRP-LA is involved in the regulation of immune defense against the Plasmodium parasite, however, the underlying mechanism needs to be further elucidated.

NOT Open Access | G-strand binding protein 2 is involved in asexual and sexual development of Plasmodium berghei

January 24, 2020 - 15:02 -- NOT Open Access
Mamoru Niikura, Toshiyuki Fukutomi, Kana Fukui, Shin-Ichi Inoue, Hiroko Asahi, Fumie Kobayashi
Parasitology International, 18 January 2020, 102059

G-strand binding protein 2 (GBP2) is a Ser/Arg-rich (SR) protein involved in mRNA surveillance and nuclear mRNA quality control in yeast. However, the roles of GBP2 in virulence and sexual development in Plasmodium parasites are unclear, although GBP2 is involved in the asexual development of Plasmodium berghei, the rodent malaria parasite. In this study, we investigated the role of GBP2 in virulence and sexual development of P. berghei using gbp2-deleted P. berghei (Δgbp2 parasites).

Evaluation of Antimalarial Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Leaves of Nuxia congesta R. Br. Ex Fresen (Buddlejaceae) in Plasmodium berghei Infected Mice

January 14, 2020 - 12:17 -- Open Access
Fenta M, Kahaliw W
Journal of Experimental Pharmacology, 16 December 2019 Volume: 11 Pages 121—134

In Ethiopia, malaria control has been complicated due to resistance of the parasite and its vectors to the current drugs. Therefore, new drugs are required to avert the problem posed by drug-resistant Plasmodium strains. There is need to investigate alternative sources of antimalarial agents and plants are potential source of antimalarial drugs. This study aimed to investigate the antimalarial activity of the leaves of N. congesta crude extract (hydromethanolic extract) and solvent fractions (n-hexane, chloroform, and aqueous fractions of crude extract) traditionally used to treat malaria in many parts of Ethiopia.

Protection induced by malaria virus-like particles containing codon-optimized AMA-1 of Plasmodium berghei

December 10, 2019 - 08:08 -- Open Access
Dong-Hun Lee, Ki-Back Chu, Hae-Ji Kang, Su-Hwa Lee, Manika Chopra, Hyo-Jick Choi, Eun-Kyung Moon, Kyung-Soo Inn and Fu-Shi Quan
Malaria Journal 2019 18:394, 3 December 2019

Despite the extensive endeavours, developing an effective malaria vaccine remains as a great challenge. Apical membrane antigen 1 (AMA-1) located on the merozoite surface of parasites belonging to the genus Plasmodium is involved in red blood cell invasion.

Essential role of GEXP15, a specific protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission

August 9, 2019 - 14:53 -- Open Access
Thomas Hollin, Caroline De Witte, Aline Fréville, Ida Chiara Guerrera, Cerina Chhuon, Jean-Michel Saliou, Fabien Herbert, Christine Pierrot, Jamal Khalife
PLoS Pathog 15(7): e1007973

The essential and distinct functions of Protein Phosphatase type 1 (PP1) catalytic subunit in eukaryotes are exclusively achieved through its interaction with a myriad of regulatory partners.


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