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malaria parasites

Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysis

October 8, 2019 - 15:00 -- Open Access
Author(s): 
Emmanuel P. Mwanga, Elihaika G. Minja, Fredros O. Okumu, et al.
Reference: 
Malaria Journal 2019 18:341, 7 October 2019

Epidemiological surveys of malaria currently rely on microscopy, polymerase chain reaction assays (PCR) or rapid diagnostic test kits for Plasmodium infections (RDTs). This study investigated whether mid-infrared (MIR) spectroscopy coupled with supervised machine learning could constitute an alternative method for rapid malaria screening, directly from dried human blood spots.

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Effects of anthropogenic landscape changes on the abundance and acrodendrophily of Anopheles (Kerteszia) cruzii, the main vector of malaria parasites in the Atlantic Forest in Brazil

April 4, 2019 - 15:37 -- Open Access
Author(s): 
Antônio Ralph Medeiros-Sousa, Rafael de Oliveira Christe, Ana Maria Ribeiro de Castro Duarte, Luis Filipe Mucci, Walter Ceretti-Junior and Mauro Toledo Marrelli
Reference: 
Malaria Journal 2019 18:110, 2 April 2019

While the data indicate that changes in landscape due to human activities lead to a reduction in An. cruzii abundance, such changes may increase the contact rate between this species and humans living on the edges of forest fragments where An. cruzii is found.

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A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle

January 17, 2017 - 15:43 -- Open Access
Author(s): 
Katarzyna Modrzynska, Claudia Pfander, Oliver Billker, et al.
Reference: 
Cell Host & Microbe, Volume 21, Issue 1, 11 January 2017, Pages 11–22

A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria parasites. This family includes sequence-specific transcription factors that are key regulators of development. However, functions for the majority of ApiAP2 genes remain unknown. Here, a systematic knockout screen in Plasmodium berghei identified ten ApiAP2 genes that were essential for mosquito transmission: four were critical for the formation of infectious ookinetes, and three were required for sporogony.

Not Open Access | Relevance of Undetectably Rare Resistant Malaria Parasites in Treatment Failure: Experimental Evidence from Plasmodium chabaudi.

May 7, 2015 - 15:51 -- NOT Open Access
Author(s): 
Huijben S, Chan BH, Read AF
Reference: 
Am J Trop Med Hyg. 2015 May 4. pii: 15-0036

We found that the rarer the resistant parasites were, the lower the likelihood of their onward transmission, but the worse the treatment failure was in terms of parasite numbers and disease severity.

Malaria Parasites Produce Volatile Mosquito Attractants

May 5, 2015 - 15:26 -- Open Access
Author(s): 
Megan Kelly, Chih-Ying Su, Chad Schaber, Jan R. Crowley, Fong-Fu Hsu, John R. Carlson, Audrey R. Odom
Reference: 
mBio vol. 6 no. 2 e00235-15, 24 March 2015

In this work, we describe the volatile chemical profile of cultured malaria parasites. Among the identified compounds are several plant-like terpenes and terpene derivatives, including known mosquito attractants.

Not Open Access | Host–parasite interactions that guide red blood cell invasion by malaria parasites

April 11, 2015 - 11:48 -- NOT Open Access
Author(s): 
Aditya S Paul, Elizabeth S Egan, Manoj T Duraisingh
Reference: 
Current Opinion in Hematology: May 2015 - Volume 22 - Issue 3 - p 220–226

Here, we review recent advances on RBC invasion by Plasmodium merozoites, focusing on specific molecular interactions between host and parasite.

Pooled Sequencing and Rare Variant Association Tests for Identifying the Determinants of Emerging Drug Resistance in Malaria Parasites

April 11, 2015 - 11:13 -- Open Access
Author(s): 
Ian H. Cheeseman, Marina McDew-White, Aung Pyae Phyo, Kanlaya Sriprawat, François Nosten and Timothy J.C. Anderson
Reference: 
Mol Biol Evol (2015) 32 (4): 1080-1090

We explored the potential of pooled sequencing to swiftly and economically identify selective sweeps due to emerging artemisinin (ART) resistance in a South-East Asian malaria parasite population.

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites

January 21, 2015 - 14:30 -- Open Access
Author(s): 
Frank Schwach, Ellen Bushell, Ana Rita Gomes, Burcu Anar, Gareth Girling, Colin Herd, Julian C. Rayner and Oliver Billker
Reference: 
Nucl. Acids Res. (28 January 2015) 43 (D1): D1176-D1182.

The PlasmoGEM web interface allows users to search a database of finished knock-out and gene tagging vectors, view details of their designs, download vector sequence in different formats and view available quality control data as well as suggested genotyping strategies.

Computational prediction of protein interactions related to the invasion of erythrocytes by malarial parasites

December 2, 2014 - 16:06 -- Open Access
Author(s): 
Xuewu Liu, Yuxiao Huang, Jiao Liang, Shuai Zhang, Yinghui Li, Jun Wang, Yan Shen, Zhikai Xu and Ya Zhao
Reference: 
BMC Bioinformatics 2014, 15:393

In this study, an expectation maximization algorithm was used to estimate the probabilities of domain-domain interactions (DDIs). Estimates of DDI probabilities were then used to infer PPI probabilities.

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Not Open Access | Antigen-Presenting Phagocytic Cells Ingest Malaria Parasites and Increase HIV Replication in a Tumor Necrosis Factor α-Dependent Manner

October 28, 2014 - 16:21 -- NOT Open Access
Author(s): 
Marika Orlov, Florin Vaida, Kathryn Williamson, Qianqian Deng, David M. Smith, Patrick E. Duffy and Robert T. Schooley
Reference: 
J Infect Dis. (2014) 210 (10): 1562-1572.

We show that iRBCs increased CD4+ T-cell expression of HLA-DR+/CD38+ (P = .001), that monocyte/macrophage depletion reduced HIV production by 40%–50% (P < .001), and that hemozoin-laden monocytes/macrophages that were preincubated with iRBCs also stimulated HIV production.

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