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plasmodium spp.

Prevalence of and risk factors for Plasmodium spp. co-infection with hepatitis B virus: a systematic review and meta-analysis

October 15, 2020 - 08:46 -- Open Access
Author(s): 
Kwuntida Uthaisar Kotepui and Manas Kotepui
Reference: 
Malaria Journal 2020 19:368, 15 October 2020

Plasmodium spp. and hepatitis B virus (HBV) are among the most common infectious diseases in underdeveloped countries. This study aimed to determine the prevalence of Plasmodium spp. and HBV co-infection in people living in endemic areas of both diseases and to assess the risk factors related to this co-infection.

NOT Open Access | A novel platform for peptide-mediated affinity capture and LC-MS/MS identification of host receptors involved in Plasmodium invasion

October 15, 2020 - 08:41 -- NOT Open Access
Author(s): 
Molina-Franky J, Plaza DF, Merali C, Merali S, Barrero C, Arévalo-Pinzón G, Patarroyo ME, Patarroyo MA
Reference: 
J Proteomics. 2020 Oct 9:104002

Successful Plasmodium falciparum invasion of red blood cells includes the orderly execution of highly specific receptor-ligand molecular interactions between the parasite's proteins and the red blood cell membrane proteins. There is a growing need for elucidating receptor-ligand pairings, which will help in understanding the parasite's biology and provide the fundamental basis for developing prophylactic or therapeutic alternatives leading to mitigating or eliminating this type of malaria.

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

August 24, 2020 - 13:25 -- Open Access
Author(s): 
Agius PA, Cutts JC, Fowkes FJI, et al.
Reference: 
PLoS Med. 2020 Aug 20;17(8):e1003177

The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of public health campaigns. We aimed to quantify the effectiveness of repellent distributed by the village health volunteer (VHV) network in the Greater Mekong Subregion (GMS) in reducing malaria in order to advance regional malaria elimination.

NOT Open Access | Kerteszia cruzii and extra-Amazonian malaria in Brazil: Challenges due to climate change in the Atlantic Forest

July 16, 2020 - 07:56 -- NOT Open Access
Author(s): 
de Azevedo TS, Lorenz C, Chiaravalloti-Neto F, Sallum MAM
Reference: 
Infect Genet Evol. 2020 Jul 12:104456

Kerteszia cruzii is a sylvatic mosquito and the primary vector of Plasmodium spp., which can cause malaria in humans in areas outside the Amazon River basin in Brazil. Anthropic changes in the natural environments are the major drivers of massive deforestation and local climate change, with serious impacts on the dynamics of mosquito communities and on the risk of acquiring malaria.

Plasmodium spp. mixed infection leading to severe malaria: a systematic review and meta-analysis

July 8, 2020 - 15:36 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, De Jesus Milanez G, Masangkay FR
Reference: 
Sci Rep. 2020 Jul 6;10(1):11068

Mixed Plasmodium malaria infections can lead to severe malaria. This systematic review and meta-analysis aimed to explore the prevalence of severe mixed Plasmodium malaria infection and to compare it with the prevalence of severe P. falciparum malaria mono-infection across the included studies. Original English-language research articles from PubMed, Scopus, and ISI Web of Science were identified and screened.

Different distribution of malaria parasite in left and right extremities of vertebrate hosts translates into differences in parasite transmission

June 26, 2020 - 12:00 -- Open Access
Author(s): 
Pigeault R, Isaïa J, Yerbanga RS, Dabiré KR, Ouédraogo JB, Cohuet A, Lefèvre T, Christe P
Reference: 
Sci Rep. 2020 Jun 23;10(1):10183

Malaria, a vector-borne disease caused by Plasmodium spp., remains a major global cause of mortality. Optimization of disease control strategies requires a thorough understanding of the processes underlying parasite transmission. While the number of transmissible stages (gametocytes) of Plasmodium in blood is frequently used as an indicator of host-to-mosquito transmission potential, this relationship is not always clear. Significant effort has been made in developing molecular tools that improve gametocyte density estimation and therefore prediction of mosquito infection rates.

Prevalence and proportion of Plasmodium spp. triple mixed infections compared with double mixed infections: a systematic review and meta-analysis

June 26, 2020 - 11:09 -- Open Access
Author(s): 
Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez and Frederick R. Masangkay
Reference: 
Malaria Journal 2020 19:224, 24 June 2020

Although mixed infection by two Plasmodium species has been recognized, mixed infection by three different Plasmodium species within one individual has not been clarified. This study sought to determine the pooled prevalence and proportion of triple mixed Plasmodium spp. infection compared with double mixed infection.

Diagnosis of Malaria Parasites Plasmodium spp. in Endemic Areas: Current Strategies for an Ancient Disease

December 23, 2019 - 14:25 -- Open Access
Author(s): 
Gitta B, Kilian N
Reference: 
Bioessays, 2019 Dec 12:e1900138

Fast and effective detection of the causative agent of malaria in humans, protozoan Plasmodium parasites, is of crucial importance for increasing the effectiveness of treatment and to control a devastating disease that affects millions of people living in endemic areas. The microscopic examination of Giemsa‐stained blood films still remains the gold‐standard in Plasmodium detection today.

Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana-Brazil): Associated Factors and Spatial Distribution

November 27, 2019 - 16:08 -- Open Access
Author(s): 
Mosnier E, Roux E, Musset L, et al.
Reference: 
Am. J. Trop. Med. Hyg., 00(0), 2019, pp. 1–12

To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l’Oyapock, located along the Brazilian border. The prevalence of Plasmodium spp. was determined using a rapid diagnostic test (RDT) and a polymerase chain reaction (PCR).

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Assessment of asymptomatic Plasmodium spp. infection by detection of parasite DNA in residents of an extra-Amazonian region of Brazil

March 15, 2018 - 07:01 -- Open Access
Author(s): 
Filomena E. C. de Alencar, Rosely dos Santos Malafronte, Angelica Espinosa Miranda, et al.
Reference: 
Malaria Journal 2018 17:113, 14 March 2018

The low incidence of cases and the low frequency of asymptomatic malaria carriers investigated make it unlikely that the transmission chain in the region is based solely on human hosts, as cases are isolated one from another by hundreds of kilometers and frequently by long periods of time, reinforcing instead the hypothesis of zoonotic transmission.

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