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p. falciparum

Severe Anemia in Papua New Guinean Children from a Malaria-Endemic Area: A Case-Control Etiologic Study

December 19, 2012 - 06:42 -- Open Access
Author(s): 
Laurens Manning, Moses Laman, Anna Rosanas-Urgell, Pascal Michon, Susan Aipit, Cathy Bona, Peter Siba, Ivo Mueller, Timothy M. E. Davis
Reference: 
PLoS Negl Trop Dis 6(12): e1972
MalariaWorld

These data show that severe anemia is multifactorial in PNG children, strongly associated with under-nutrition and certain common infections, and potentially preventable through vitamin A supplementation and improved nutrition, completion of vaccination schedules, and intermittent preventive antimalarial treatment using non-chloroquine/amodiaquine-based regimens.

Medical Treatment: 

Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria

December 17, 2012 - 14:00 -- Open Access
Author(s): 
Damien R. Drew, Anthony N. Hodder, Danny W. Wilson, Michael Foley, Ivo Mueller, Peter M. Siba, Arlene E. Dent, Alan F. Cowman, James G. Beeson
Reference: 
PLoS ONE 7(12): e51023
MalariaWorld

Apical Membrane Antigen 1 (AMA1) is a leading malaria vaccine candidate and a target of naturally-acquired human immunity. Plasmodium falciparum AMA1 is polymorphic and in vaccine trials it induces strain-specific protection.

Medical Treatment: 

Reduction of multiplicity of infections but no change in msp2 genetic diversity in Plasmodium falciparum isolates from Congolese children after introduction of artemisinin-combination therapy

December 10, 2012 - 08:55 -- Open Access
Author(s): 
Ibara-Okabande R, Koukouikila-Koussounda F, Ndounga M, Vouvoungui J, Malonga V, Casimiro P, Ibara J, Sidibe A, Ntoumi F
Reference: 
Malaria Journal 2012, 11:410 (7 December 2012)
MalariaWorld

This study shows that the introduction of ACT in the Republic of Congo has reduced the MOI but not the genetic diversity of P. falciparum isolates from children living in Southern districts of Brazzaville.

Person: 

Plasmodium vivax and Plasmodium falciparum infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants

November 29, 2012 - 08:24 -- Open Access
Author(s): 
Khaireh BA, Briolant S, Pascual A, Mokrane M, Machault V, Travaillé C, Khaireh MA, Farah IH, Ali HM, Abdi AA, Ayeh SN, Darar HY, Ollivier L, Waiss MK, Bogreau H, Rogier C, Pradines B
Reference: 
Malaria Journal 2012, 11:395 (28 November 2012)
MalariaWorld

This is the first study that assessed the seroprevalence of P. vivax in the Republic of Djibouti.

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Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras

November 27, 2012 - 15:51 -- Open Access
Author(s): 
Lopez AC, Ortiz A, Coello J, Sosa-Ochoa W, Torres RE, Banegas EI, Jovel I, Fontecha GA
Reference: 
Malaria Journal 2012, 11:391 (26 November 2012)
MalariaWorld

To date, this is the most complete report on molecular characterization of P. vivax and P. falciparum field isolates in Honduras with regards to genetic diversity. These results indicate that P. vivax and P. falciparum parasite populations are highly diverse in Honduras despite the low level of transmission.

Country: 
Medical Condition: 

Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum

November 26, 2012 - 12:55 -- Open Access
Author(s): 
Clement F, Dewar V, Van Braeckel E, Desombere I, Dewerchin M, Swysen C, Demoitié M, Jongert E, Cohen J, Leroux-Roels G, Cambron P
Reference: 
Malaria Journal 2012, 11:384 (22 November 2012)
MalariaWorld

This ELISA, specific for antibodies directed against the CSP repeat region, can be used as a standard assay for the determination of humoral immunogenicity in the development of any CSP-based P. falciparum malaria vaccine.

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization

November 26, 2012 - 08:03 -- Open Access
Author(s): 
Pornthanakasem W, Kongkasuriyachai D, Uthaipibull C, Yuthavong Y, Leartsakulpanich U
Reference: 
Malaria Journal 2012, 11:387 (22 November 2012)
MalariaWorld

Distinct compartment localizations of PfSHMT were observed between cytoplasmic and mitochondrial isoforms, and evidence was provided for the indispensable role of plasmodial cSHMT indicating it as a valid target for development of novel anti-malarials.

A flow cytometry-based workflow for detection and quantification of anti-plasmodial antibodies in vaccinated and naturally exposed individuals

November 12, 2012 - 09:45 -- Open Access
Author(s): 
Ajua A, Engleitner T, Esen M, Theisen M, Issifou S, Mordmüller B
Reference: 
Malaria Journal 2012, 11:367 (6 November 2012)
MalariaWorld

The current workflow advances detection and quantification of anti-plasmodial antibodies through improvement of a bias-prone, low-throughput to an unbiased, semi-automated, scalable method.

Medical Condition: 

Interactions and Potential Implications of Plasmodium falciparum-Hookworm Coinfection in Different Age Groups in South-Central Côte d'Ivoire

November 12, 2012 - 08:14 -- Open Access
Author(s): 
Aurélie A. Righetti, Dominik Glinz, Lukas G. Adiossan, Ahou-Yah G. Koua, Sébastien Niamké, Richard F. Hurrell, Rita Wegmüller, Eliézer K. N'Goran, Jürg Utzinger
Reference: 
PLoS Negl Trop Dis 6(11): e1889
MalariaWorld

Our findings suggest that interaction between P. falciparum and light-intensity hookworm infections vary with age and, in school-aged children, may benefit the host through preventing iron deficiency anemia.

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