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p. falciparum

Phosphoethanolamine-N-methyltransferase is a potential biomarker for the diagnosis of P. knowlesi and P. falciparum malaria

March 20, 2018 - 14:28 -- Open Access
Author(s): 
Robert G. E. Krause, J. P. Dean Goldring
Reference: 
PLoS ONE 13(3): e0193833

PMT, like the pan-specific LDH biomarker used in RDT tests, is both soluble, present at comparable concentrations in the parasite and constitutes a promising antimalarial drug target.

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Medical Treatment: 

Malaria prevalence in asymptomatic and symptomatic children in Kiwangwa, Bagamoyo district, Tanzania

May 30, 2017 - 18:01 -- Open Access
Author(s): 
Deborah Sumari, Felista Mwingira, Majige Selemani, Joseph Mugasa, Kefas Mugittu and Paul Gwakisa
Reference: 
Malaria Journal 2017 16:222, 25 May 2017

A substantial difference in prevalence of symptomatic and asymptomatic infections observed in Kiwangwa ward underpins the use of molecular tools in malaria surveillance aiming at estimating prevalence and transmission.

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Decreased prevalence of sepsis but not mild or severe P. falciparum malaria is associated with pre-existing filarial infection

July 29, 2013 - 18:53 -- Open Access
Author(s): 
Panda M, Sahoo PK, Mohapatra AD, kanti Dutta S, Thatoi PK, Tripathy R, Das BK, Satpathy AK, Ravindran B
Reference: 
Parasites & Vectors 2013, 6:203 (10 July 2013)
MalariaWorld

This suggests that successful control of filariasis by employing mass drug administration, could potentially contribute to an increase in incidence of sepsis and cerebral malaria in human communities.

Successful Human Infection with P. falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection

July 23, 2013 - 15:58 -- Open Access
Author(s): 
Matthew B. Laurens, Peter Billingsley, Kirsten E. Lyke, et al.
Reference: 
PLoS ONE 8(7): e689
MalariaWorld

Here, we report results from a subsequent CHMI study using 3 PfSPZ-infected mosquitoes reared aseptically to validate the initial clinical trial. We also compare results of safety, tolerability, and transmission dynamics in participants undergoing CHMI using 3 PfSPZ-infected mosquitoes reared aseptically to published studies of CHMI using 5 mosquitoes.

Not Open Access | Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia

July 18, 2013 - 17:27 -- NOT Open Access
Author(s): 
Samuel B. Anyona, Prakasha Kempaiah, Gregory C. Davenport, John M. Vulule, James B. Hittner, John M. Ong’echa, Douglas J. Perkins
Reference: 
Biochemical and Biophysical Research Communications, Volume 436, Issue 4, 12 July 2013, Pages 585-590
MalariaWorld

Since children with malaria often have increased incidence of additional infections, such as bacteremia and HIV-1, we extend our previous findings by investigating COX-2 and PGE2 in children with falciparum malaria and co-infection with either bacteremia or HIV-1. Plasma bicyclo-PGE2/creatinine levels and peripheral blood COX-2 transcripts were significantly reduced in co-infected children relative to those with malaria mono-infection.

Not Open Access | Identification and Functional Analysis of the Primary Pantothenate Transporter, PfPAT, of the Human Malaria Parasite Plasmodium falciparum

July 13, 2013 - 13:15 -- NOT Open Access
Author(s): 
Yoann Augagneur, Lise Jaubert, Choukri Ben Mamoun, et al.
Reference: 
July 12, 2013 The Journal of Biological Chemistry, 288, 20558-20567.
MalariaWorld

Here we report the identification and functional characterization of the first protozoan pantothenate transporter, PfPAT, from P. falciparum. We show using cell biological, biochemical, and genetic analyses that this transporter is localized to the parasite plasma membrane and plays an essential role in parasite intraerythrocytic development.

Insights Gained from P. falciparum Cultivation in Modified Media

July 13, 2013 - 13:08 -- Open Access
Author(s): 
Sanjay A. Desai
Reference: 
The Scientific World Journal, Volume 2013 (2013)
MalariaWorld

Here, I review recent studies that used modified culture conditions to challenge these assumptions and explore parasite physiology. The findings are relevant to understanding in vivo parasite phenotypes and the prioritization of antimalarial targets.

Severe Plasmodium falciparum and Plasmodium vivax malaria among adults at Kassala Hospital, eastern Sudan

May 7, 2013 - 07:56 -- Open Access
Author(s): 
Abdallah TM, Abdeen MT, Ahmed IS, Hamdan HZ, Magzoub M, Adam I
Reference: 
Malaria Journal 2013, 12:148 (1 May 2013)
MalariaWorld

Severe malaria due to P. falciparum and P. vivax malaria is an existing entity among adults in eastern Sudan. Patients with severe P. falciparum and P. vivax develop similar disease manifestations.

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NOT Open Access | Comparative evaluation of efficacy and safety of artesunate–lumefantrine vs. artemether–lumefantrine fixed-dose combination in the treatment of uncomplicated Plasmodium falciparum malaria

April 11, 2013 - 08:21 -- NOT Open Access
Author(s): 
Anil Pareek, Nitin Chandurkar, Sucheta Lakhani, et al.
Reference: 
Tropical Medicine & International Health, Volume 18, Issue 5, pages 578–587, May 2013
MalariaWorld

Artesunate (100 mg)/lumefantrine (480 mg) fixed-dose combination could add one more option to currently available artemisinin combinations in treatment of uncomplicated P. falciparum malaria.

Medical Treatment: 

Imported malaria in Finland 2003-2011: prospective nationwide data with rechecked background information

March 19, 2013 - 08:41 -- Open Access
Author(s): 
Siikamäki H, Kivelä P, Lyytikäinen O, Kantele A
Reference: 
Malaria Journal 2013, 12:93 (14 March 2013)
MalariaWorld

Information on compliance with chemoprophylactic regimen cannot be relied on, and it should be rechecked if malaria is suspected.

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