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Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study

September 23, 2020 - 08:53 -- Open Access
Hartley MA, Hofmann N, D'Acremont V, et al.
PLoS Med. 2020 Sep 21;17(9):e1003318

Low-density (LD) Plasmodium infections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. The clinical impact of these LD infections is unknown. This study investigates the clinical presentation and outcome of untreated febrile children with LD infections attending primary care facilities in a moderately endemic area of Tanzania.

NOT Open Access | Prevalence of Asymptomatic Malaria Parasitemia in Odisha, India: A Challenge to Malaria Elimination

August 17, 2020 - 13:08 -- NOT Open Access
Kumari P, Sinha S, Gahtori R, Yadav CP, Pradhan MM, Rahi M, Pande V, Anvikar AR
Am J Trop Med Hyg. 2020 Aug 10

The prevalence of malaria in India is decreasing, but it remains a major concern for public health administration. The role of submicroscopic malaria and asymptomatic malaria parasitemia and their persistence is being explored. A cross-sectional survey was conducted in the Kandhamal district of Odisha (India) during May-June 2017. Blood samples were collected from 1897 individuals for screening of asymptomatic parasitemia. Samples were screened using rapid diagnostic tests (RDTs) and examined microscopically for Plasmodium species.

NOT Open Access | Increase hemoglobin level in severe malarial anemia while controlling parasitemia: A mathematical model

August 3, 2020 - 16:21 -- NOT Open Access
Siewe N, Friedman A
Mathematical Biosciences Volume 326, August 2020, 108374

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by immune cells; it can play a protective or deleterious role in response to pathogens. The intracellular malaria parasite secretes a similar protein, PMIF. The present paper is concerned with severe malarial anemia (SMA), where MIF suppresses the recruitment of red blood cells (RBCs) from the spleen and the bone marrow.

NOT Open Access | The efficacy of intermittent preventive therapy in the eradication of peripheral and placental parasitemia in a malaria-endemic environment, as seen in a tertiary hospital in Abuja, Nigeria

December 23, 2019 - 14:30 -- NOT Open Access
Umemmuo MU, Agboghoroma CO, Iregbu KC
Int J Gynaecol Obstet. 2019 Dec 12.

To determine whether intermittent preventive therapy in pregnancy (IPTp) eradicates peripheral and placental malaria and improves birth weight.

Impact evaluation of malaria control interventions on morbidity and all-cause child mortality in Mali, 2000–2012

November 17, 2018 - 08:39 -- Open Access
Kassoum Kayentao, Lia S. Florey, Jules Mihigo, Abdoul Doumbia, Aliou Diallo, Diakalia Koné, Ogobara Doumbo and Erin Eckert
Malaria Journal 2018 17:424

Taken as a whole, the evidence supports the conclusion that malaria control interventions substantially contributed to the observed decline in ACCM in Mali from 2000 to 2012, even in the context of continued high prevalence of parasitaemia explained by contextual factors such as climate change and political instability.

Effect of chronic khat (Catha edulis, Forsk) use on outcome of Plasmodium berghei ANKA infection in Swiss albino mice

April 7, 2015 - 15:34 -- Open Access
Tsige Ketema, Moti Yohannes, Esayas Alemayehu and Argaw Ambelu
BMC Infectious Diseases 2015, 15:170

The finding of this study showed that khat use was strongly associated with increment of levels of liver and kidney biomarkers, leucopenia, severe anemia, rise in level of inflammation biomarkers: C-reactive protein (CRP), uric acid (UA), increased monocyte-lymphocyte count ratio (MLCR), manifestation of cerebral malaria symptoms such as ataxia, paralysis and deviation of the head but with no pulmonary edema.

Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia

December 17, 2013 - 19:06 -- Open Access
Richard J. Maude, Kamolrat Silamut, Arjen M. Dondorp, et al.
Clin Infect Dis. (2014) 58 (1): 11-21.

Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria.

Not Open Access | Genetic characterization of Plasmodium falciparum allelic variants infecting mothers at delivery and their children during their first plasmodial infections

October 16, 2013 - 18:43 -- NOT Open Access
Célia Dechavanne, Charlotte Pierrat, Florence Migot-Nabias, et al.
Infection, Genetics and Evolution, Volume 20, December 2013, Pages 16-25

The hypothesis of this study is that this increased susceptibility might be related to infections by parasites expressing the same blood stage allele’s antigens as those to which the infants were exposed in utero.

VAR2CSA Signatures of High Plasmodium falciparum Parasitemia in the Placenta

August 5, 2013 - 15:36 -- Open Access
Eduard Rovira-Vallbona, Isadora Monteiro, Alfredo Mayor, et al.
PLoS ONE 8(7): e69753.

These results suggest that a higher binding efficiency to CSA rather than reduced antigenicity might provide a biological advantage to parasites with high parasite density signatures in VAR2CSA.

Home- or community-based programmes for treating malaria.

June 10, 2013 - 14:52 -- Open Access
Okwundu CI, Nagpal S, Musekiwa A, Sinclair D.
Cochrane Database Syst Rev. 2013 May 31;5

Randomized controlled trials (RCTs) and non-RCTs that evaluated the effects of a home- or community-based programme for treating malaria in a malaria endemic setting.


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