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Label-free imaging and classification of live P. falciparum enables high performance parasitemia quantification without fixation or staining

August 10, 2021 - 17:49 -- Open Access
Lebel P, Dial R, Vemuri VNP, Garcia V, DeRisi J, Gómez-Sjöberg R
PLoS Comput Biol. 2021 Aug 9;17(8):e1009257

Manual microscopic inspection of fixed and stained blood smears has remained the gold standard for Plasmodium parasitemia analysis for over a century. Unfortunately, smear preparation consumes time and reagents, while manual microscopy is skill-dependent and labor-intensive.

NOT Open Access | Evaluating the dual reactivity on SD bioline malaria rapid diagnosis tests as a potential indicator of high parasitemia due to Plasmodium falciparum

July 28, 2021 - 14:17 -- NOT Open Access
Nana RRD, Makoge V, Ngum NL, Amvongo-Adjia N, Singh V, Somo RM
Pathog Glob Health. 2021 Jul 26:1-9

The co-reactivity of the Plasmodium histidine-rich protein 2 (HRP2) and lactate dehydrogenase (pLDH) in malaria rapid diagnosis tests (mRDTs) as a potential indicator of high parasitemia linked to Plasmodium falciparum was evaluated in the reported study from Cameroon. The samples were screened for malaria using both mRDTs (SD bioline HRP2/pLDH), light microscopy and further confirmed by Plasmodium species-specific PCR assay.

NOT Open Access | Erythrocyte Binding Activity of PkDBPalphaII of Plasmodium knowlesi Isolated from High and Low Parasitemia Cases

December 16, 2020 - 10:53 -- NOT Open Access
Mohd Bukhari FD, Lau YL, Fong MY
Am J Trop Med Hyg. 2020 Dec 14

Invasion of Plasmodium knowlesi merozoite into human erythrocytes involves molecular interaction between the parasite's Duffy binding protein (PkDBPαII) and the Duffy antigen receptor for chemokines on the erythrocytes. This study investigates the binding activity of human erythrocyte with PkDBPαII of P. knowlesi isolates from high and low parasitemic patients in an erythrocyte binding assay.

NOT Open Access | Association of Malnutrition with Subsequent Malaria Parasitemia among Children Younger than Three years in Kenya: A Secondary Data Analysis of the Asembo Bay Cohort Study

November 18, 2020 - 12:20 -- NOT Open Access
Donovan CV, McElroy P, Adair L, Pence BW, Oloo AJ, Lal A, Bloland P, Nahlen B, Juliano JJ, Meshnick S
Am J Trop Med Hyg. 2020 Nov 16

Malaria and malnutrition remain primary causes of morbidity and mortality among children younger than 5 years in Africa. Studies investigating the association between malnutrition and subsequent malaria outcomes are inconsistent. We studied the effects of malnutrition on incidence and prevalence of malaria parasitemia in data from a cohort studied in the 1990s.

NOT Open Access | A modified two-color flow cytometry assay to quantify in-vitro reinvasion and determine invasion phenotypes at low Plasmodium falciparum parasitemia

November 4, 2020 - 16:03 -- NOT Open Access
Ngoh IA, Anong DN, Fru JC, Bojang F, Mbye H, Amambua-Ngwa A
Exp Parasitol. 2020 Nov;218:107969

Invasion of human red blood cells (RBCs) by Plasmodium parasites is a crucial yet poorly characterised phenotype. Two-color flow cytometry (2cFCM) promises to be a very sensitive and high throughput method for phenotyping parasite invasion. However, current protocols require high (~1.0%) parasitemia for assay set-up and need to be adapted for low parasitemia samples, which are becoming increasingly common in low transmission settings.

Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study

September 23, 2020 - 08:53 -- Open Access
Hartley MA, Hofmann N, D'Acremont V, et al.
PLoS Med. 2020 Sep 21;17(9):e1003318

Low-density (LD) Plasmodium infections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. The clinical impact of these LD infections is unknown. This study investigates the clinical presentation and outcome of untreated febrile children with LD infections attending primary care facilities in a moderately endemic area of Tanzania.

NOT Open Access | Prevalence of Asymptomatic Malaria Parasitemia in Odisha, India: A Challenge to Malaria Elimination

August 17, 2020 - 13:08 -- NOT Open Access
Kumari P, Sinha S, Gahtori R, Yadav CP, Pradhan MM, Rahi M, Pande V, Anvikar AR
Am J Trop Med Hyg. 2020 Aug 10

The prevalence of malaria in India is decreasing, but it remains a major concern for public health administration. The role of submicroscopic malaria and asymptomatic malaria parasitemia and their persistence is being explored. A cross-sectional survey was conducted in the Kandhamal district of Odisha (India) during May-June 2017. Blood samples were collected from 1897 individuals for screening of asymptomatic parasitemia. Samples were screened using rapid diagnostic tests (RDTs) and examined microscopically for Plasmodium species.

NOT Open Access | Increase hemoglobin level in severe malarial anemia while controlling parasitemia: A mathematical model

August 3, 2020 - 16:21 -- NOT Open Access
Siewe N, Friedman A
Mathematical Biosciences Volume 326, August 2020, 108374

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by immune cells; it can play a protective or deleterious role in response to pathogens. The intracellular malaria parasite secretes a similar protein, PMIF. The present paper is concerned with severe malarial anemia (SMA), where MIF suppresses the recruitment of red blood cells (RBCs) from the spleen and the bone marrow.

NOT Open Access | The efficacy of intermittent preventive therapy in the eradication of peripheral and placental parasitemia in a malaria-endemic environment, as seen in a tertiary hospital in Abuja, Nigeria

December 23, 2019 - 14:30 -- NOT Open Access
Umemmuo MU, Agboghoroma CO, Iregbu KC
Int J Gynaecol Obstet. 2019 Dec 12.

To determine whether intermittent preventive therapy in pregnancy (IPTp) eradicates peripheral and placental malaria and improves birth weight.

Impact evaluation of malaria control interventions on morbidity and all-cause child mortality in Mali, 2000–2012

November 17, 2018 - 08:39 -- Open Access
Kassoum Kayentao, Lia S. Florey, Jules Mihigo, Abdoul Doumbia, Aliou Diallo, Diakalia Koné, Ogobara Doumbo and Erin Eckert
Malaria Journal 2018 17:424

Taken as a whole, the evidence supports the conclusion that malaria control interventions substantially contributed to the observed decline in ACCM in Mali from 2000 to 2012, even in the context of continued high prevalence of parasitaemia explained by contextual factors such as climate change and political instability.


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