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clinical malaria

Addressing challenges in routine health data reporting in Burkina Faso through Bayesian spatiotemporal prediction of weekly clinical malaria incidence

October 7, 2020 - 16:01 -- Open Access
Rouamba T, Samadoulougou S, Kirakoya-Samadoulougou F
Sci Rep. 2020 Oct 6;10(1):16568

Sub-Saharan African (SSA) countries' health systems are often vulnerable to unplanned situations that can hinder their effectiveness in terms of data completeness and disease control. For instance, in Burkina Faso following a workers' strike, comprehensive data on several diseases were unavailable for a long period in 2019. Weather, seasonal-malaria-chemoprevention (SMC), free healthcare, and other contextual data, which are purported to influence malarial disease, provide opportunities to fit models to describe the clinical malaria data and predict the disease spread.

NOT Open Access | Maximizing Impact: Can Interventions to Prevent Clinical Malaria Reduce Parasite Transmission

September 15, 2020 - 14:30 -- NOT Open Access
McCann RS, Cohee LM, Goupeyou-Youmsi J, Laufer MK
Trends Parasitol. 2020 Sep 8:S1471-4922(20)30196-3

Malaria interventions may reduce the burden of clinical malaria disease, the transmission of malaria parasites, or both. As malaria interventions are developed and evaluated, including those interventions primarily targeted at reducing disease, they may also impact parasite transmission.

NOT Open Access | Diagnosis of clinical malaria in endemic settings

August 11, 2020 - 07:36 -- NOT Open Access
Varo R, Balanza N, Mayor A, Bassat Q
Expert Rev Anti Infect Ther. 2020 Aug 9

Malaria continues to be a major global health problem, with over 228 million cases and 405,000 deaths estimated to occur annually. Rapid and accurate diagnosis of malaria is essential to decrease the burden and impact of this disease, particularly in children. We aimed to review the main available techniques for the diagnosis of clinical malaria in endemic settings and explore possible future options to improve its rapid recognition.

High-efficiency enrichment enables identification of aptamers to circulating Plasmodium falciparum-infected erythrocytes

June 17, 2020 - 13:06 -- Open Access
Oteng EK, Gu W, McKeague M
Sci Rep. 2020 Jun 16; 10(1):9706

Plasmodium falciparum is the causative agent of the deadliest human malaria. New molecules are needed that can specifically bind to erythrocytes that are infected with P. falciparum for diagnostic purposes, to disrupt host-parasite interactions, or to deliver chemotherapeutics. Aptamer technology has the potential to revolutionize biological diagnostics and therapeutics; however, broad adoption is hindered by the high failure rate of the systematic evolution of ligands by exponential enrichment (SELEX). Here we performed parallel SELEX experiments to compare the impact of two different methods for single-strand recovery on the efficiency of aptamer enrichment.

Multiplicity of Asymptomatic Plasmodium falciparum Infections and Risk of Clinical Malaria: A Systematic Review and Pooled Analysis of Individual Participant Data

February 22, 2020 - 17:16 -- Open Access
Eldh M, Hammar U, Arnot D, Beck HP, Garcia A, Liljander A, Mercereau-Puijalon O, Migot-Nabias F, Mueller I, Ntoumi F, Ross A, Smith T, Sondén K, Vafa Homann M, Yman V, Felger I, Färnert A
The Journal of Infectious Diseases, Volume 221, Issue 5, 1 March 2020, Pages 775–785

The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity in asymptomatic P. falciparum infections—that is, the number of coinfecting clones—affects the subsequent risk of clinical malaria in populations living under different levels of transmission.

Risk factor assessment for clinical malaria among forest-goers in a pre-elimination setting in Phu Yen Province, Vietnam

December 30, 2019 - 14:25 -- Open Access
Sara E. Canavati, Gerard C. Kelly, Nicholas J. Martin, et al.
Malaria Journal 2019 18:435, 20 December 2019

The transition from malaria control to elimination requires understanding and targeting interventions among high-risk populations. In Vietnam, forest-goers are often difficult to test, treat and follow-up for malaria because they are highly mobile. If undiagnosed, forest-goers can maintain parasite reservoirs and contribute to ongoing malaria transmission.

Clinical malaria and the potential risk of anaemia among preschool-aged children: a population-based study of the 2015-2016 Malawi micronutrient survey

November 28, 2019 - 06:41 -- Open Access
Ntenda PAM, Chilumpha S, Mwenyenkulu ET, Kazambwe JF, El-Meidany W.
Infectious Diseases of Poverty volume 8, Article number: 95 (2019)

Anaemia and malaria are common and life-threatening diseases among preschool-aged children in many tropical and subtropical areas, and Malawi is no exception. Accordingly, this study aimed to examine the association of referral clinical malaria with anemia (hemoglobin [Hb] < 110 g/L) in preschool-aged children in Malawi.


Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes

October 1, 2019 - 14:29 -- Open Access
Chester J. Joyner, Cristiana F. A. Brito, Mary R. Galinski, et al.
PLoS Pathog 15(9): e1007974

Plasmodium relapses are attributed to the activation of dormant liver-stage parasites and are responsible for a significant number of recurring malaria blood-stage infections.

Medical Condition: 

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria

March 5, 2019 - 15:55 -- Open Access
Wen-Qiang He, Ahmad Rushdi Shakri, Ivo Mueller, et al.
PLoS Negl Trop Dis 13(2): e0006987

Antibodies to the key parasite invasion ligands PvDBPII and PvEBPII are good correlates of protection against P. vivax malaria in PNG

Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity

April 11, 2017 - 16:02 -- Open Access
Temitope W. Ademolue, Yaw Aniweh, Kwadwo A. Kusi and Gordon A. Awandare
Malaria Journal 2017 16:145, 11 April 2017

Taken together, the data demonstrate a strong relationship between the prevailing transmission intensity, parasitaemia levels and the magnitude of inflammatory responses induced during clinical malaria.



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