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clinical malaria

Multiplicity of Asymptomatic Plasmodium falciparum Infections and Risk of Clinical Malaria: A Systematic Review and Pooled Analysis of Individual Participant Data

February 22, 2020 - 17:16 -- Open Access
Eldh M, Hammar U, Arnot D, Beck HP, Garcia A, Liljander A, Mercereau-Puijalon O, Migot-Nabias F, Mueller I, Ntoumi F, Ross A, Smith T, Sondén K, Vafa Homann M, Yman V, Felger I, Färnert A
The Journal of Infectious Diseases, Volume 221, Issue 5, 1 March 2020, Pages 775–785

The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity in asymptomatic P. falciparum infections—that is, the number of coinfecting clones—affects the subsequent risk of clinical malaria in populations living under different levels of transmission.

Risk factor assessment for clinical malaria among forest-goers in a pre-elimination setting in Phu Yen Province, Vietnam

December 30, 2019 - 14:25 -- Open Access
Sara E. Canavati, Gerard C. Kelly, Nicholas J. Martin, et al.
Malaria Journal 2019 18:435, 20 December 2019

The transition from malaria control to elimination requires understanding and targeting interventions among high-risk populations. In Vietnam, forest-goers are often difficult to test, treat and follow-up for malaria because they are highly mobile. If undiagnosed, forest-goers can maintain parasite reservoirs and contribute to ongoing malaria transmission.

Clinical malaria and the potential risk of anaemia among preschool-aged children: a population-based study of the 2015-2016 Malawi micronutrient survey

November 28, 2019 - 06:41 -- Open Access
Ntenda PAM, Chilumpha S, Mwenyenkulu ET, Kazambwe JF, El-Meidany W.
Infectious Diseases of Poverty volume 8, Article number: 95 (2019)

Anaemia and malaria are common and life-threatening diseases among preschool-aged children in many tropical and subtropical areas, and Malawi is no exception. Accordingly, this study aimed to examine the association of referral clinical malaria with anemia (hemoglobin [Hb] < 110 g/L) in preschool-aged children in Malawi.


Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes

October 1, 2019 - 14:29 -- Open Access
Chester J. Joyner, Cristiana F. A. Brito, Mary R. Galinski, et al.
PLoS Pathog 15(9): e1007974

Plasmodium relapses are attributed to the activation of dormant liver-stage parasites and are responsible for a significant number of recurring malaria blood-stage infections.

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Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria

March 5, 2019 - 15:55 -- Open Access
Wen-Qiang He, Ahmad Rushdi Shakri, Ivo Mueller, et al.
PLoS Negl Trop Dis 13(2): e0006987

Antibodies to the key parasite invasion ligands PvDBPII and PvEBPII are good correlates of protection against P. vivax malaria in PNG

Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity

April 11, 2017 - 16:02 -- Open Access
Temitope W. Ademolue, Yaw Aniweh, Kwadwo A. Kusi and Gordon A. Awandare
Malaria Journal 2017 16:145, 11 April 2017

Taken together, the data demonstrate a strong relationship between the prevailing transmission intensity, parasitaemia levels and the magnitude of inflammatory responses induced during clinical malaria.


Filariasis Attenuates Anemia and Proinflammatory Responses Associated with Clinical Malaria: A Matched Prospective Study in Children and Young Adults

November 12, 2012 - 07:57 -- Open Access
Housseini Dolo, Yaya I. Coulibaly, Amy D. Klion, et al.
PLoS Negl Trop Dis 6(11): e1890

These data suggest that pre-existent filarial infection attenuates immune responses associated with severe malaria and protects against anemia, but has little effect on susceptibility to or severity of acute malaria infection.

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