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plasmodium falciparum

NOT Open Access | Down‐selecting circumsporozoite protein‐based malaria vaccine: A comparison of malaria sporozoite challenge model

April 16, 2019 - 08:12 -- NOT Open Access
Author(s): 
Fitri Amelia, Mitsuhiro Iyori, Talha Bin Emran, Daisuke S. Yamamoto, Kento Genshi, Hiromu Otsuka, Yutaro Onoue, Yenni Yusuf, Ashekul Islam, Shigeto Yoshida
Reference: 
Parasite Immunology Volume41, Issue5 May 2019 e12624

Plasmodium falciparum circumsporozoite protein (PfCSP) is the main target antigen in development of pre‐erythrocytic malaria vaccines.

Age-dependent increase in antibodies that inhibit Plasmodium falciparum adhesion to a subset of endothelial receptors

April 14, 2019 - 16:41 -- Open Access
Author(s): 
Oumar Attaher, Almahamoudou Mahamar, Michal Fried, et al.
Reference: 
Malaria Journal 2019 18:128, 11 April 2019

Age is associated with increased levels of antibodies that reduce adhesion of children’s IE to three of the ten endothelial receptors evaluated here.

African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker

April 14, 2019 - 16:35 -- Open Access
Author(s): 
Didier Leroy, Fiona Macintyre, Didier Ménard, et al.
Reference: 
Malaria Journal 2019 18:126, 10 April 2019

These findings were considered to sharply contrast with the recent description of increased sensitivity to PPQ of Ugandan parasite isolates.

Sensitive real-time PCR detection of Plasmodium falciparum parasites in whole blood by erythrocyte membrane protein 1 gene amplification

April 4, 2019 - 16:07 -- Open Access
Author(s): 
Bryan Grabias, Edward Essuman, Isabella A. Quakyi and Sanjai Kumar
Reference: 
Malaria Journal 2019 18:116, 2 April 2019

These results establish PfEMP1 as a novel amplification target for highly sensitive detection of both acute infections from filter paper samples and submicroscopic asymptomatic low-grade infections.

NOT Open Access | Viability Screen of LOPAC1280 Reveals Tyrosine Kinase Inhibitor Tyrphostin A9 as a Novel Partner Drug for Artesunate Combinations To Target the Plasmodium falciparum Ring Stage

April 2, 2019 - 11:46 -- NOT Open Access
Author(s): 
Jie Xin Tong, Sarah E. L. Ang, Esther H. N. Tan and Kevin S. W. Tan
Reference: 
Antimicrob Agents Chemother 63:e02389-18

The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies.

The prevalence and antifolate drug resistance profiles of Plasmodium falciparum in study participants randomized to discontinue or continue cotrimoxazole prophylaxis

April 2, 2019 - 11:18 -- Open Access
Author(s): 
Dennis W. Juma, Peninah Muiruri, Krista Yuhas, Grace John-Stewart, Ronald Ottichilo, John Waitumbi, Benson Singa, Christina Polyak, Edwin Kamau
Reference: 
PLoS Negl Trop Dis 13(3): e0007223

The frequencies of mutations in pfdhfr and pfdhps genes were higher in STOP-CTX arm compared to CTX arm, suggesting cotrimoxazole effectively controls and selects against SP-resistant parasites.

High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

March 27, 2019 - 16:02 -- Open Access
Author(s): 
Tingting Jiang, Jiangtao Chen, Jian Li, et al.
Reference: 
Malaria Journal 2019 18:101, 26 March 2019

Bioko Island possesses a high prevalence of the Pfdhfr triple mutation (CIRNI) and Pfdhps single mutation (SGKAA), which will undermine the pharmaceutical effect of SP for malaria treatment strategies.

Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

March 26, 2019 - 15:50 -- Open Access
Author(s): 
Andreas Masch, Abed Nasereddin, Conrad Kunick, et al.
Reference: 
Malaria Journal 2019 18:89, 21 March 2019

The attachment of alkylamino side chains leads to the improvement of antiplasmodial activity and aqueous solubility of selective PfGSK-inhibitors belonging to the class of 4-phenylthieno[2,3-b]pyridines.

Medical Condition: 

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

March 20, 2019 - 15:48 -- Open Access
Author(s): 
Shivendra G. Tewari, Krithika Rajaram, Patric Schyman, Russell Swift, Jaques Reifman, Sean T. Prigge and Anders Wallqvist
Reference: 
Malaria Journal 2019 18:86, 19 March 2019

The metabolic network analysis presented here suggests that P. falciparum invokes specific purine-recycling pathways to compensate for hypoxanthine deprivation and maintains a hypoxanthine pool for purine-based nucleic acid synthesis.

Detection of Plasmodium falciparum infected Anopheles gambiae using near-infrared spectroscopy

March 20, 2019 - 15:47 -- Open Access
Author(s): 
Marta F. Maia, Melissa Kapulu, Michelle Muthui, Martin G. Wagah, Heather M. Ferguson, Floyd E. Dowell, Francesco Baldini and Lisa-Ranford Cartwright
Reference: 
Malaria Journal 2019 18:85, 19 March 2019

Accurate, low-cost, reagent-free screening of mosquito populations enabled by NIRS could revolutionize surveillance and elimination strategies for the most important human malaria parasite in its primary African vector species.

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