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plasmodium falciparum

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion

June 11, 2019 - 15:05 -- Open Access
L. Brock Thornton, Paige Teehan, Zhicheng Dou, et al.
PLoS Pathog 15(6): e1007775

Toxoplasma gondii is an apicomplexan parasite with the ability to use foodborne, zoonotic, and congenital routes of transmission that causes severe disease in immunocompromised patients.

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

June 11, 2019 - 15:02 -- Open Access
Barbara H. Stokes, Euna Yoo, David A. Fidock, et al.
PLoS Pathog 15(6): e1007722

Therapeutics with novel modes of action and a low risk of generating resistance are urgently needed to combat drug-resistant Plasmodium falciparum malaria.

Medical Treatment: 

Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort

June 11, 2019 - 14:50 -- Open Access
Rafiou Adamou, Célia Dechavanne, David Courtin, et al.
Malaria Journal 2019 18:194, 11 June 2019

Substantial evidence indicates that cytophilic IgG responses to Plasmodium falciparum merozoite antigens play a role in protection from malaria. The specific targets mediating immunity remain unclear. Evaluating antibody responses in infants naturally-exposed to malaria will allow to better understand the establishment of anti-malarial immunity and to contribute to a vaccine development by identifying the most appropriate merozoite candidate antigens.

A retrospective analysis on the transmission of Plasmodium falciparum and Plasmodium vivax: the case of Adama City, East Shoa Zone, Oromia, Ethiopia

June 11, 2019 - 14:49 -- Open Access
Temesgen File, Hunduma Dinka and Lemu Golassa
Malaria Journal 2019 18:193, 11 June 2019

Malaria is more often considered a problem of the rural poor and the disease has been overlooked in urban settings for centuries due to the assumption that economic development in urban areas results in better life conditions, such as improved housing, drainage system and environmental changes that makes urban areas not conducive for breeding of the malaria vector. But, for many African countries, including Ethiopia, in most urban areas, although there are rapid developments, they are characterized by poor housing, lack of sanitation and drainage of surface water that would provide favourable conditions for vector breeding. Limited studies have been conducted as far as urban malaria is concerned in Ethiopia. The purpose of this study was to assess the status of falciparum and vivax malaria transmission in Adama City, Eastern Shoa Zone, Oromia, Ethiopia. Understanding the local epidemiology of malaria will help policy makers and other stakeholders to design and implement tailored cost effective and efficient intervention strategies targeting urban malaria.

Medical Condition: 

Persistent transmission of Plasmodium malariae and Plasmodium ovale species in an area of declining Plasmodium falciparum transmission in eastern Tanzania

June 3, 2019 - 15:25 -- Open Access
Victor Yman, Grace Wandell, Anna Färnert, et al.
PLoS Negl Trop Dis 13(5): e0007414

A reduction in the global burden of malaria over the past two decades has encouraged efforts for regional malaria elimination.

Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites

June 3, 2019 - 15:19 -- Open Access
Tanmaya Atre, Tanisha M. Robinson, Tatyana Savransky, Sheetij Dutta, Judith E. Epstein and Elke S. Bergmann-Leitner
Malaria Journal 2019 18:186, 29 May 2019

Whole parasite vaccination is an efficacious strategy to induce sterile immunity and to prevent malaria transmission. Understanding the mechanism and response of immune cells to vaccines plays a critical role in deciphering correlates of protection against infection and disease. Immunoassays, such as ELISpot, are commonly used to assess the immunogenicity of vaccines towards T cells and B cells. To date, these assays only analyse responses to specific antigens since they are based on recombinant parasite-derived proteins or peptides. There is the need for an agnostic approach that allows the evaluation of all sporozoite-associated antigens.

Efficacy and safety of artemether–lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial

May 28, 2019 - 11:31 -- Open Access
Clifford G. Banda, Mike Chaponda, Victor Mwapasa, et al.
Malaria Journal 2019 18:180, 24 May 2019

HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Artemether–lumefantrine (AL) is the most commonly used ACT for treatment of falciparum malaria in Africa but there is limited evidence on the safety and efficacy of AL in HIV-infected individuals on ART, among whom drug–drug interactions are expected. Day-42 adequate clinical and parasitological response (ACPR) and incidence of adverse events was assessed in HIV-infected individuals on efavirenz-based ART with uncomplicated falciparum malaria treated with AL.

Medical Treatment: 

NOT Open Access | The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum

May 20, 2019 - 14:49 -- NOT Open Access
Miray Tonk, Christine Pierrot, Alejandro Cabezas-Cruz, Mohammad Rahnamaeian, Jamal Khalife & Andreas Vilcinskas
Parasitology Research June 2019, Volume 118, Issue 6, pp 1993–1998

Antimicrobial peptides (AMPs) are important components of the vertebrate and invertebrate innate immune systems.

Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum

May 20, 2019 - 14:48 -- Open Access
Xu Zhang, Noah Alexander, Irina Leonardi, Christopher Mason, Laura A. Kirkman, Kirk W. Deitsch
PLoS Biol 17(5): e3000271

Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease.

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

May 20, 2019 - 14:32 -- Open Access
Avnish Patel, Abigail J. Perrin, David A. Baker, et al.
PLoS Biol 17(5): e3000264

Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in malaria parasites is poorly understood.


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