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Plasmodium knowlesi

Plasmodium knowlesi malaria an emerging public health problem in Hulu Selangor, Selangor Malaysia (2009-2013): epidemiologic and entomologic analysis

September 16, 2014 - 17:04 -- Open Access
Author(s): 
Vythilingam I, Lim YA, Mahmud R, et al.
Reference: 
Parasites & Vectors 2014, 7 :436 (15 September 2014)

In the present study, only An. introlatus was positive for oocysts. Kernel Density analysis showed that P. knowlesi hotspot areas overlapped with areas where the infected An. introlatus was discovered. This further strengthens the hypothesis that An. introlatusis is the vector for P. knowlesi in the Hulu Selangor district.

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Disease Progression in Plasmodium knowlesi Malaria Is Linked to Variation in Invasion Gene Family Members

August 19, 2014 - 14:15 -- Open Access
Author(s): 
Atique M. Ahmed, Miguel M. Pinheiro, Janet Cox-Singh, et al.
Reference: 
PLoS Negl Trop Dis 8(8): e3086

Emerging pathogens undermine initiatives to control the global health impact of infectious diseases.

Transmission and Control of Plasmodium knowlesi: A Mathematical Modelling Study

July 30, 2014 - 06:36 -- Open Access
Author(s): 
Natsuko Imai, Michael T. White, Azra C. Ghani, Chris J. Drakeley
Reference: 
PLoS Negl Trop Dis 8(7): e2978

This model simulates conditions where P. knowlesi transmission may occur and the potential impact of control measures.

High proportion of knowlesi malaria in recent malaria cases in Malaysia

May 14, 2014 - 12:13 -- Open Access
Author(s): 
Yusof R, Lau Y, Mahmud R, Fong M, Jelip J, Ngian H, Mustakim S, Mat Hussin H, Marzuki N, Mohd Ali M
Reference: 
Malaria Journal 2014, 13 :168 (3 May 2014)

In addition to Sabah and Sarawak, which have been known for high prevalence of P. knowlesi infection, the findings from this study highlight the widespread distribution of P. knowlesi in many Peninsular Malaysia states.

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Defining the Geographical Range of the Plasmodium knowlesi Reservoir

April 1, 2014 - 13:29 -- Open Access
Author(s): 
Catherine L. Moyes, Andrew J. Henry, Simon I. Hay, et al.
Reference: 
PLoS Negl Trop Dis 8(3): e2780

We have ranked subnational areas within the potential disease range according to evidence for presence of a disease risk to humans, providing geographical evidence to support decisions on prevention, management and prophylaxis.

Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways

November 11, 2013 - 18:42 -- Open Access
Author(s): 
Partho Sen, Henri J Vial and Ovidiu Radulescu
Reference: 
BMC Systems Biology 2013, 7:123
MalariaWorld

The quantitative analysis was used to understand eventual links between different pathways. The major source of phosphatidylcholine (PC) is the CDP-choline Kennedy pathway.

Accurate identification of the six human Plasmodium spp. causing imported malaria, including Plasmodium ovale wallikeri and Plasmodium knowlesi

September 17, 2013 - 15:41 -- Open Access
Author(s): 
Calderaro A, Piccolo G, Gorrini C, Rossi S, Montecchini S, Dell’Anna ML, De Conto F, Medici MC, Chezzi C, Arcangeletti MC
Reference: 
Malaria Journal 2013, 12:321 (13 September 2013)
MalariaWorld

These assays revealed an excellent analytical sensitivity and no cross-reactivity versus other Plasmodium spp. infecting humans, suggesting their usefulness for an accurate and complete diagnosis of imported malaria.

Plasmodium knowlesi and HIV co-infection in a German traveller to Thailand

August 22, 2013 - 08:42 -- Open Access
Author(s): 
Ehrhardt J, Trein A, Kremsner PG, Frank M
Reference: 
Malaria Journal 2013, 12:283 (13 August 2013)
MalariaWorld

A case of Plasmodium knowlesi and HIV co-infection is reported in a German traveller returning from Thailand.

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Not Open Access | The compact conformation of the Plasmodium knowlesi myosin tail interacting protein MTIP in complex with the C-terminal helix of myosin A

August 6, 2013 - 14:20 -- NOT Open Access
Author(s): 
Stewart Turley, Susmita Khamrui, Lawrence W. Bergman, Wim G.J. Hol
Reference: 
Molecular and Biochemical Parasitology, Volume 190, Issue 2, August 2013, Pages 56-59

Here we report the crystal structure of the compact P. knowlesi MTIP•MyoA complex. It appears that, depending on the pH, P. knowlesi MTIP can adopt either the compact or the extended conformation to interact with MyoA.

Increased detection of Plasmodium knowlesi in Sandakan division, Sabah as revealed by PlasmoNexTM

August 5, 2013 - 15:26 -- Open Access
Author(s): 
Goh XT, Lim YA, Vythilingam I, Chew CH, Lee PC, Ngui R, Tan TC, Yap NJ, Nissapatorn V, Chua KH
Reference: 
Malaria Journal 2013, 12:264 (31 July 2013)
MalariaWorld

Therefore, the aim of the present epidemiological study was to investigate the incidence and distribution of P. knowlesi as well as other Plasmodium species in this division based on a most recent developed hexaplex PCR system (PlasmoNex™).

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