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Plasmodium knowlesi

Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species

June 2, 2015 - 13:31 -- Open Access
Paul C. S. Divis, Balbir Singh, Fread Anderios, Shamilah Hisam, Asmad Matusop, Clemens H. Kocken, Samuel A. Assefa, Craig W. Duffy, David J. Conway
PLoS Pathog 11(5): e1004888

Human malaria parasite species were originally acquired from other primate hosts and subsequently became endemic, then spread throughout large parts of the world.

NOT Open Access | Detection of human malaria using recombinant Plasmodium knowlesi merozoire surface protein-1 (MSP-119) expressed in Escherichia coli

May 6, 2015 - 13:55 -- NOT Open Access
Parthasarathy Sonaimuthu, Fei Wen Cheong, Lit Chein Chin, Rohela Mahmud, Mun Yik Fong, Yee Ling Lau
Experimental Parasitology, Volume 153, June 2015, Pages 118–122

Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality and morbidity.

Low Levels of Polymorphisms and No Evidence for Diversifying Selection on the Plasmodium knowlesi Apical Membrane Antigen 1 Gene

April 27, 2015 - 13:15 -- Open Access
Bart W. Faber, Khamisah Abdul Kadir, Roberto Rodriguez-Garcia, Edmond J. Remarque, Frederick A. Saul, Brigitte Vulliez-Le Normand, Graham A. Bentley, Clemens H. M. Kocken, Balbir Singh
PLoS ONE 10(4): e012440

Infection with Plasmodium knowlesi, a zoonotic primate malaria, is a growing human health problem in Southeast Asia.


Not Open Access | Plasmodium knowlesi Malaria During Pregnancy

March 18, 2015 - 14:52 -- NOT Open Access
Bridget E. Barber, Elspeth Bird, Christopher S. Wilkes, Timothy William, Matthew J. Grigg, Uma Paramaswaran, Jayaram Menon, Jenarun Jelip, Tsin W. Yeo and Nicholas M. Anstey
J Infect Dis. (2015) 211 (7): 1104-1110.

To investigate comparative risk and consequences of knowlesi malaria during pregnancy, we reviewed (1) Sabah Health Department malaria-notification records created during 2012–2013, (2) prospectively collected data from all females with polymerase chain reaction (PCR)–confirmed malaria who were admitted to a Sabah tertiary care referral hospital during 2011–2014, and (3) malaria microscopy and clinical data recorded at a Sabah tertiary care women and children's hospital during 2010–2014.

Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures

March 16, 2015 - 14:11 -- Open Access
Stacey A Lapp, Sachel Mok, Lei Zhu, Hao Wu, Peter R Preiser, Zybnek Bozdech, Mary R Galinski
Malaria Journal 2015, 14:110 (13 March 2015)

This study demonstrates how gene expression in P. knowlesi blood-stage parasites can differ dramatically depending on whether the parasites are grown in vivo, with only one cycle of development ex vivo, or as an adapted isolate in long-term in vitro culture.

Distinct genetic difference between the Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from North Borneo and Peninsular Malaysia

March 2, 2015 - 18:50 -- Open Access
Mun-Yik Fong, Sarah Rashdi, Ruhani Yusof, Yee-Ling Lau
Malaria Journal 2015, 14:91 (21 February 2015)

This study is the first to report the genetic diversity and natural selection of PkDBPαII of P. knowlesi from Borneo Island.


Molecular detection of human Plasmodium species in Sabah using PlasmoNex™ multiplex PCR and hydrolysis probes real-time PCR

February 11, 2015 - 16:35 -- Open Access
Ping Lee, Eric Chong, Fread Anderios, Yvonne AL Lim, Ching Chew, Kek Chua
Malaria Journal 2015, 14:28 (28 January 2015)

Multiplex PCR accelerate the speed in the diagnosis of malaria. The PlasmoNex™ PCR assay seems to
be more accurate than real-time PCR in the speciation of all five human malaria parasites.

Identification of circulating biomarkers in sera of Plasmodium knowlesi-infected malaria patients – comparison against Plasmodium vivax infection

February 10, 2015 - 15:40 -- Open Access
Yeng Chen, Choon K Chan, Jesinda P Kerishnan, Yee L Lau, Yin-Ling Wong and Subash CB Gopinath
BMC Infectious Diseases 2015, 15:49

In the present study, we have employed two-dimensional gel electrophoresis-coupled immunoblotting techniques and mass spectrometry to identify novel circulating markers in sera from P. knowlesi-infected patients.

Changing epidemiology of malaria in Sabah, Malaysia: increasing incidence of Plasmodium knowlesi

November 4, 2014 - 07:10 -- Open Access
Timothy William, Jenarun Jelip, Jayaram Menon, Fread Anderios, Rashidah Mohammad, Tajul A Awang Mohammad, Matthew J Grigg, Tsin W Yeo, Nicholas M Anstey, Bridget E Barber
Malaria Journal 2014, 13:390 (2 October 2014)

Notifications of P. malariae/P. knowlesi in Sabah are increasing, with this trend likely reflecting a true increase in incidence of P. knowlesi and presenting a major threat to malaria control and elimination in Malaysia.

Detection of Plasmodium knowlesi DNA in the urine and faeces of a Japanese macaque (Macaca fuscata) over the course of an experimentally induced infection

September 25, 2014 - 12:37 -- Open Access
Kawai S, Sato M, Kato-Hayashi N, Kishi H, Huffman MA, Maeno Y, Culleton R, Nakazawa S
Malaria Journal 2014, 13 :373 (19 September 2014)

Urine and faeces were obtained from a Plasmodium knowlesi infected-Japanese macaque (Macaca fuscata) over the course of an experimentally induced infection. P. knowlesi DNA (PkDNA) extracted from urine and faeces were monitored by nested PCR targeting the P. knowlesi specific cytochrome b (cytb) gene.


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