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Plasmodium knowlesi

NOT Open Access | Clinical implications of a gradual dormancy concept in malaria

May 23, 2016 - 14:55 -- NOT Open Access
Joachim Richter, Gabriele Franken, Martha C. Holtfreter, Susanne Walter, Alfons Labisch & Heinz Mehlhorn
Parasitology Research, June 2016, Volume 115, Issue 6, pp 2139-2148

Malaria recurrences after an initially successful therapy and malarial fever occurring a long time after infection are well-known problems in malariology.

Not Open Access: A Sensitive, Colorimetric, High-Throughput Loop-Mediated Isothermal Amplification Assay for the Detection of Plasmodium knowlesi

May 17, 2016 - 15:49 -- NOT Open Access
Sumudu Britton, Qin Cheng, Matthew J. Grigg, Timothy William, Nick M. Anstey, and James S. McCarthy
Am J Trop Med Hyg 15-0670

This study reports the development of a simple, sensitive, colorimetric, high-throughput loop-mediated isothermal amplification assay (HtLAMP) diagnostic test using novel primers for the detection of P. knowlesi. 

Predicting the geographical distributions of the macaque hosts and mosquito vectors of Plasmodium knowlesi malaria in forested and non-forested areas

May 3, 2016 - 14:55 -- Open Access
Moyes C, Shearer F, Hay S, et al.
Parasites & Vectors 2016, 9 :242 (28 April 2016)

Our results support the hypothesis that conversion of intact forest into disturbed forest (for example plantations or timber concessions), or the creation of vegetation mosaics, will increase the probability that members of the Leucosphyrus Complex occur at these locations, as well as bringing humans into these areas.

Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite

April 6, 2016 - 15:13 -- Open Access
Selasi Dankwa, Caeul Lim, Manoj T. Duraisingh, et al.
Nature Communications 7

We show that two P. knowlesi invasion ligands, PkDBPβ and PkDBPγ, bind specifically to Neu5Gc-containing receptors. A human-adapted P. knowlesi line invades human RBCs independently of Neu5Gc, with duplication of the sialic acid-independent invasion ligand, PkDBPα and loss of PkDBPγ.

Genetic diversity and natural selection in the rhoptry-associated protein 1 (RAP-1) of recent Plasmodium knowlesi clinical isolates from Malaysia

February 8, 2016 - 19:03 -- Open Access
Mira Syahfriena Amir Rawa, Mun-Yik Fong and Yee-Ling Lau
Malaria Journal 2016 15:62, 5 February 2016

The present study found higher genetic polymorphism in the PkRAP-1 gene than the polymorphism level reported in a previous study.

NOT Open Access | Identification and characterization of epitopes on Plasmodium knowlesi merozoite surface protein-142 (MSP-142) using synthetic peptide library and phage display library

January 20, 2016 - 14:57 -- NOT Open Access
Fei Wen Cheong, Mun Yik Fong, Yee Ling Lau
Acta Tropica, Volume 154, February 2016, Pages 89–94

Plasmodium knowlesi can cause potentially life threatening human malaria. The Plasmodium merozoite surface protein-142 (MSP-142) is a potential target for malaria blood stage vaccine, and for diagnosis of malaria.

Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi

October 27, 2015 - 07:23 -- Open Access
Samuel Assefa, Caeul Lim, Balbir Singh, et al.
PNAS October 20, 2015 vol. 112 no. 42 13027-13032

Malaria cases caused by the zoonotic parasite Plasmodium knowlesi are being increasingly reported throughout Southeast Asia and in travelers returning from the region.

Non-invasive surveillance for Plasmodium in reservoir macaque species

October 14, 2015 - 08:51 -- Open Access
Josephine Siregar, Christina Faust, Lydia Murdiyarso, Lis Rosmanah, Uus Saepuloh, Andrew Dobson, Diah Iskandriati
Malaria Journal 2015, 14:404 (12 October 2015)

Faecal samples can be used for detection of malaria infection in field surveys of macaques, even when there are no parasites visible in thin blood smears.

Simian malaria in wild macaques: first report from Hulu Selangor district, Selangor, Malaysia

October 12, 2015 - 16:47 -- Open Access
Rumana Akter, Indra Vythilingam, Loke Khaw, Rajes Qvist, Yvonne Lim, Frankie Sitam, Balan Venugopalan, Shamala Sekaran
Malaria Journal 2015, 14:386 (5 October 2015)

This study has provided evidence to elucidate the presence of transmission of malaria parasites among the local macaques in Hulu Selangor.


Recognition of Human Erythrocyte Receptors by the Tryptophan-Rich Antigens of Monkey Malaria Parasite Plasmodium knowlesi

September 30, 2015 - 17:24 -- Open Access
Kriti Tyagi, Deepali Gupta, Yagya D. Sharma, et al.
PLoS ONE 10(9): e0138691

Recognition and sharing of human erythrocyte receptor(s) by PkTRAgs with human parasite ligands could be part of the strategy adopted by the monkey malaria parasite to establish inside the heterologous human host.


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