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Plasmodium knowlesi

Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations

October 3, 2017 - 17:18 -- Open Access
Ernest Diez Benavente, Paola Florez de Sessions, Taane G. Clark, et al.
PLoS Genet 13(9): e1007008

The macaque parasite Plasmodium knowlesi is a significant concern in Malaysia where cases of human infection are increasing.


World Malaria Report: time to acknowledge Plasmodium knowlesi malaria

April 5, 2017 - 14:48 -- Open Access
Bridget E. Barber, Giri S. Rajahram, Matthew J. Grigg, Timothy William and Nicholas M. Anstey
Malaria Journal 2017 16:135, 31 March 2017

The WHO World Malaria Report has an appropriate focus on falciparum and vivax malaria, the major causes of global mortality and morbidity.

Diagnostic challenges and case management of the first imported case of Plasmodium knowlesi in Sri Lanka

March 28, 2017 - 15:15 -- Open Access
A. Dewanee Ranaweera, Manjula N. Danansuriya, Deepika Fernando, et al.
Malaria Journal 2017 16:126, 21 March 2017

Plasmodium knowlesi should be suspected in patients returning from countries in the South Asian region where the parasite is prevalent and when blood smear results are inconclusive.


Plasmodium knowlesi Skeleton-Binding Protein 1 Localizes to the ‘Sinton and Mulligan’ Stipplings in the Cytoplasm of Monkey and Human Erythrocytes

November 2, 2016 - 17:08 -- Open Access
Amuza Byaruhanga Lucky, Miako Sakaguchi, Yuko Katakai, Satoru Kawai, Kazuhide Yahata, Thomas J. Templeton, Osamu Kaneko
PLoS ONE 11(10): e0164272.

The malaria parasite, Plasmodium, exports protein products to the infected erythrocyte to introduce modifications necessary for the establishment of nutrient acquisition and surface display of host interaction ligands.

Distribution and prevalence of malaria parasites among long-tailed macaques (Macaca fascicularis) in regional populations across Southeast Asia

September 6, 2016 - 18:12 -- Open Access
Xinjun Zhang, Khamisah Abdul Kadir, Leslie Fabiola Quintanilla-Zariñan, Jason Villano, Paul Houghton, Hongli Du, Balbir Singh and David Glenn Smith
Malaria Journal 2016 15:450, 2 September 2016


The prevalence of malaria parasites, including those that are transmissible to humans, varied among all sampled regional populations of long-tailed macaques in Southeast Asia.

Estimating Geographical Variation in the Risk of Zoonotic Plasmodium knowlesi Infection in Countries Eliminating Malaria

August 19, 2016 - 18:37 -- Open Access
Freya M. Shearer, Zhi Huang, Catherine L. Moyes, et al.
PLoS Negl Trop Dis 10(8): e0004915

We have produced the first map of P. knowlesi malaria risk, at a fine-scale resolution, to identify priority areas for surveillance based on regions with sparse data and high estimated risk.

Vertical stratification of adult mosquitoes (Diptera: Culicidae) within a tropical rainforest in Sabah, Malaysia

July 23, 2016 - 17:09 -- Open Access
Hayley L. Brant, Robert M. Ewers, Indra Vythilingam, Chris Drakeley, Suzan Benedick and John D. Mumford
Malaria Journal 2016 15:370, 19 July 2016

This study demonstrates the potential ability of An. balabacensis to transmit P. knowlesi between canopy-dwelling simian hosts and ground-dwelling humans, and that forest disturbance increases the abundance of this disease vector.

Transfusion-transmitted severe Plasmodium knowlesi malaria in a splenectomized patient with beta-thalassaemia major in Sabah, Malaysia: a case report

July 19, 2016 - 16:12 -- Open Access
Elspeth M. Bird, Uma Parameswaran, Bridget E. Barber, et al.
Malaria Journal 2016 15:357, 12 July 2016

This case demonstrates that acquisition of P. knowlesi from blood transfusion can occur, and that clinical consequences can be severe.

Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi

July 11, 2016 - 16:04 -- Open Access
Robert W. Moon, Hazem Sharaf, Anthony A. Holder, et al.
PNAS June 28, 2016 vol. 113 no. 26 7231-7236

The dominant cause of malaria in Malaysia is now Plasmodium knowlesi, a zoonotic parasite of cynomolgus macaque monkeys found throughout South East Asia.

NOT Open Access | Adaptation of the [3H]Hypoxanthine Uptake Assay for In Vitro-Cultured Plasmodium knowlesi Malaria Parasites

June 23, 2016 - 15:02 -- NOT Open Access
Megan S. J. Arnold, Jessica A. Engel, Ming Jang Chua, Gillian M. Fisher, Tina S. Skinner-Adams, and Katherine T. Andrews
Antimicrob. Agents Chemother. July 2016 vol. 60 no. 7 4361-4363

The zoonotic malaria parasite Plasmodium knowlesi has recently been established in continuous in vitro culture.


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