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Plasmodium knowlesi

Diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia

July 31, 2018 - 15:29 -- Open Access
Md Atique Ahmed, Yee Ling Lau and Fu-Shi Quan
Malaria Journal 2018 17:274, 27 July 2018

This study is the first to report on the genetic diversity and natural selection of full-length pktrap.


In vitro invasion inhibition assay using antibodies against Plasmodium knowlesi Duffy binding protein alpha and apical membrane antigen protein 1 in human erythrocyte-adapted P. knowlesi A1-H.1 strain

July 31, 2018 - 15:28 -- Open Access
Fauzi Muh, Seong-Kyun Lee, Mohammad Rafiul Hoque, Jin-Hee Han, Ji-Hoon Park, Egy Rahman Firdaus, Robert W. Moon, Yee Ling Lau and Eun-Taek Han
Malaria Journal 2018 17:272, 27 July 2018

These data provide support for the validation of in vitro growth inhibition assay using antibodies of DBPα and AMA1 in human-adapted P. knowlesi parasite PkA1-H.1 strain.

Exposure and infection to Plasmodium knowlesi in case study communities in Northern Sabah, Malaysia and Palawan, The Philippines

June 21, 2018 - 17:15 -- Open Access
Kimberly M. Fornace, Lou S. Herman, Chris J. Drakeley, et al.
PLoS Negl Trop Dis 12(6): e0006432

This is the first study to describe serological exposure to P. knowlesi and associated risk factors within endemic communities.

Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure

June 21, 2018 - 17:14 -- Open Access
Lou S. Herman, Kimberly Fornace, Kevin K. A. Tetteh, et al.
PLoS Negl Trop Dis 12(6): e0006457

The PkSERA3 antigen 2 had the highest relative variable importance in all models.

A dual colour fluorescence in situ hybridization (FISH) assay for identifying the zoonotic malaria parasite Plasmodium knowlesi with a potential application for the specific diagnosis of knowlesi malaria in peripheral-level laboratories of Southeast Asia

May 30, 2018 - 07:08 -- Open Access
Jyotsna Shah, Akhila Poruri, Olivia Mark, Urmila Khadilka, Franziska Mohring, Robert W. Moon and Ranjan Ramasamy
Shah et al. Parasites & Vectors (2017) 10:342

Plasmodium knowlesi is primarily responsible for zoonotic malaria in several Southeast Asian countries. Precise identification of the parasite in the blood of patients presently relies on an expensive and elaborate PCR procedure because microscopic examination of blood and other available field identification techniques lack adequate specificity. 


Two clusters of Plasmodium knowlesi cases in a malaria elimination area, Sabang Municipality, Aceh, Indonesia

May 8, 2018 - 14:56 -- Open Access
Herdiana Herdiana, Irnawati Irnawati, William A. Hawley, et al.
Malaria Journal 2018 17:186, 2 May 2018

In malaria elimination areas, malaria cases are sporadic and consist predominantly of imported cases.

First case of human infection with Plasmodium knowlesi in Laos

March 28, 2018 - 15:34 -- Open Access
Moritoshi Iwagami, Masami Nakatsu, Shigeyuki Kano, et al.
PLoS Negl Trop Dis 12(3): e0006244

On July 17, 2016, a 12-year-old Laotian boy living in Bengvilay village, Sanamxay district, Attapeu province (adjacent to Cambodia) in Laos visited Bengvilay Health Center.


Genetic diversity and natural selection of Plasmodium knowlesi merozoite surface protein 1 paralog gene in Malaysia

March 15, 2018 - 07:00 -- Open Access
Md Atique Ahmed, Muh Fauzi and Eun-Taek Han
Malaria Journal 2018 17:115, 14 March 2018

This study is the first to report on the genetic diversity and natural selection of pkmsp1p.


NOT Open Access | Clinical features and management of Plasmodium knowlesi infections in humans

February 1, 2018 - 16:18 -- NOT Open Access
Cyrus Daneshvar, Timothy William, Timothy M. E. Davis
Parasitology, Volume 145 / Issue 1, January 2018, pp 18 – 31

Plasmodium knowlesi is a simian malaria of primarily the macaque species of South East Asia.

Plasmodium knowlesi: experimental model, zoonotic pathogen and golden opportunity?

February 1, 2018 - 16:16 -- Open Access
Janet Cox-Singh
Parasitology, Volume 145 / Issue 1, January 2018, pp 1 – 5

Consequently, malaria research was, and still is, underpinned by the quest to understand, control and prevent malaria caused by P. falciparum.


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