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Plasmodium knowlesi

NOT Open Access | Is the Epidemiology of Plasmodium knowlesi Changing, and What Does This Mean for Malaria Control in Southeast Asia?

January 20, 2020 - 16:31 -- NOT Open Access
Author(s): 
Karunajeewa H, Berman J
Reference: 
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 368–369

It has long been clear that the “monkey-malaria” species, Plasmodium knowlesi, is capable of infecting humans. Its name comes from Robert Knowles, the British parasitologist who first demonstrated experimental monkey–human transmission and pioneered its use as “malaria therapy” for syphilis and leprosy from as early as 1932 [1].

Plasmodium knowlesi Malaria in Sabah, Malaysia, 2015-2017: Ongoing Increase in Incidence Despite Near-elimination of the Human-only Plasmodium Species

January 20, 2020 - 16:11 -- Open Access
Author(s): 
Cooper DJ, Rajahram GS, Barber BE, et al.
Reference: 
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 361–367

Malaysia aims to eliminate malaria by 2020. However, while cases of Plasmodium falciparum and Plasmodium vivax have decreased substantially, the incidence of zoonotic malaria from Plasmodium knowlesi continues to increase, presenting a major challenge to regional malaria control efforts. Here we report incidence of all Plasmodium species in Sabah, including zoonotic P. knowlesi, during 2015–2017.

Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia

November 30, 2019 - 04:44 -- Open Access
Author(s): 
Ahmed MA, Saif A, Quan FS
Reference: 
PLoS One. 2019 Nov 21;14(11):e0224743.

Human infections due to the monkey malaria parasite Plasmodium knowlesi are increasingly being reported from Malaysia. The parasite causes high parasitaemia, severe and fatal malaria in humans thus there is a need for urgent measures for its control.

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NOT Open Access | Identification of Plasmodium knowlesi Merozoite Surface Protein-119 (PkMSP-119 ) novel binding peptides from a phage display library

November 19, 2019 - 06:38 -- NOT Open Access
Author(s): 
Ting Goh X, Heng Chua K, Pin Kee B, Lim YAL
Reference: 
Trop Med Int Health. 2019 Nov 16

Plasmodium knowlesi, the fifth human malaria parasite, has caused mortality in humans. We aimed to identify P. knowlesi novel binding peptides through a random linear dodecapeptide phage display targeting the 19‐kDa fragment of Merozoite Surface Protein‐1 protein.

Plasmodium knowlesi clinical isolates from Malaysia show extensive diversity and strong differential selection pressure at the merozoite surface protein 7D (MSP7D)

May 3, 2019 - 17:21 -- Open Access
Author(s): 
Md. Atique Ahmed and Fu-Shi Quan
Reference: 
Malaria Journal 2019 18:150, 29 April 2019

Background

The high proportion of human cases due to the simian malaria parasite Plasmodium knowlesi in Malaysia is a cause of concern, as they can be severe and even fatal. Merozoite surface protein 7 (MSP7) is a multigene family which forms a non-covalent complex with MSP-1 prior to receptor-ligand recognition in Plasmodium falciparum and thus an important antigen for vaccine development. However, no study has been done in any of the ortholog family members in P. knowlesi from clinical samples. This study investigates the level of polymorphism, haplotypes, and natural selection acting at the pkmsp-7D gene in clinical samples from Malaysia.

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Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

March 13, 2019 - 14:40 -- Open Access
Author(s): 
Gael Davidson, Tock H. Chua, Angus Cook, Peter Speldewinde and Philip Weinstein
Reference: 
Malaria Journal 2019 18:66, 8 March 2019

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia.

Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study

February 6, 2019 - 15:50 -- Open Access
Author(s): 
Dorothy Wavinya Nyamai and Özlem Tastan Bishop
Reference: 
Malaria Journal 2019 18:34, 6 February 2019

This study showed that, despite, functional and structural conservation, Plasmodium aaRSs have key differences from the human homologues.

Laboratory challenges of Plasmodium species identification in Aceh Province, Indonesia, a malaria elimination setting with newly discovered P. knowlesi

December 12, 2018 - 16:12 -- Open Access
Author(s): 
Farah N. Coutrier, Yusrifar K. Tirta, Rintis Noviyanti, et al.
Reference: 
PLoS Negl Trop Dis 12(11): e0006924

The discovery of the life-threatening zoonotic infection Plasmodium knowlesi has added to the challenges of prompt and accurate malaria diagnosis and surveillance.

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Within-population genetic diversity and population structure of Plasmodium knowlesi merozoite surface protein 1 gene from geographically distinct regions of Malaysia and Thailand

December 4, 2018 - 14:47 -- Open Access
Author(s): 
Md Atique Ahmed, Ki-Back Chu, Indra Vythilingam and Fu-Shi Quan
Reference: 
Malaria Journal 2018 17:442, 29 November 2018

This study is the first to report on inter country genetic diversity and population structure of P. knowlesi based on msp1.

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