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Plasmodium knowlesi

NOT Open Access | Identification of Plasmodium knowlesi Merozoite Surface Protein-119 (PkMSP-119 ) novel binding peptides from a phage display library

November 19, 2019 - 06:38 -- NOT Open Access
Ting Goh X, Heng Chua K, Pin Kee B, Lim YAL
Trop Med Int Health. 2019 Nov 16

Plasmodium knowlesi, the fifth human malaria parasite, has caused mortality in humans. We aimed to identify P. knowlesi novel binding peptides through a random linear dodecapeptide phage display targeting the 19‐kDa fragment of Merozoite Surface Protein‐1 protein.

Plasmodium knowlesi clinical isolates from Malaysia show extensive diversity and strong differential selection pressure at the merozoite surface protein 7D (MSP7D)

May 3, 2019 - 17:21 -- Open Access
Md. Atique Ahmed and Fu-Shi Quan
Malaria Journal 2019 18:150, 29 April 2019


The high proportion of human cases due to the simian malaria parasite Plasmodium knowlesi in Malaysia is a cause of concern, as they can be severe and even fatal. Merozoite surface protein 7 (MSP7) is a multigene family which forms a non-covalent complex with MSP-1 prior to receptor-ligand recognition in Plasmodium falciparum and thus an important antigen for vaccine development. However, no study has been done in any of the ortholog family members in P. knowlesi from clinical samples. This study investigates the level of polymorphism, haplotypes, and natural selection acting at the pkmsp-7D gene in clinical samples from Malaysia.


Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

March 13, 2019 - 14:40 -- Open Access
Gael Davidson, Tock H. Chua, Angus Cook, Peter Speldewinde and Philip Weinstein
Malaria Journal 2019 18:66, 8 March 2019

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia.

Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study

February 6, 2019 - 15:50 -- Open Access
Dorothy Wavinya Nyamai and Özlem Tastan Bishop
Malaria Journal 2019 18:34, 6 February 2019

This study showed that, despite, functional and structural conservation, Plasmodium aaRSs have key differences from the human homologues.

Laboratory challenges of Plasmodium species identification in Aceh Province, Indonesia, a malaria elimination setting with newly discovered P. knowlesi

December 12, 2018 - 16:12 -- Open Access
Farah N. Coutrier, Yusrifar K. Tirta, Rintis Noviyanti, et al.
PLoS Negl Trop Dis 12(11): e0006924

The discovery of the life-threatening zoonotic infection Plasmodium knowlesi has added to the challenges of prompt and accurate malaria diagnosis and surveillance.


Within-population genetic diversity and population structure of Plasmodium knowlesi merozoite surface protein 1 gene from geographically distinct regions of Malaysia and Thailand

December 4, 2018 - 14:47 -- Open Access
Md Atique Ahmed, Ki-Back Chu, Indra Vythilingam and Fu-Shi Quan
Malaria Journal 2018 17:442, 29 November 2018

This study is the first to report on inter country genetic diversity and population structure of P. knowlesi based on msp1.

Diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia

July 31, 2018 - 15:29 -- Open Access
Md Atique Ahmed, Yee Ling Lau and Fu-Shi Quan
Malaria Journal 2018 17:274, 27 July 2018

This study is the first to report on the genetic diversity and natural selection of full-length pktrap.


In vitro invasion inhibition assay using antibodies against Plasmodium knowlesi Duffy binding protein alpha and apical membrane antigen protein 1 in human erythrocyte-adapted P. knowlesi A1-H.1 strain

July 31, 2018 - 15:28 -- Open Access
Fauzi Muh, Seong-Kyun Lee, Mohammad Rafiul Hoque, Jin-Hee Han, Ji-Hoon Park, Egy Rahman Firdaus, Robert W. Moon, Yee Ling Lau and Eun-Taek Han
Malaria Journal 2018 17:272, 27 July 2018

These data provide support for the validation of in vitro growth inhibition assay using antibodies of DBPα and AMA1 in human-adapted P. knowlesi parasite PkA1-H.1 strain.

Exposure and infection to Plasmodium knowlesi in case study communities in Northern Sabah, Malaysia and Palawan, The Philippines

June 21, 2018 - 17:15 -- Open Access
Kimberly M. Fornace, Lou S. Herman, Chris J. Drakeley, et al.
PLoS Negl Trop Dis 12(6): e0006432

This is the first study to describe serological exposure to P. knowlesi and associated risk factors within endemic communities.


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