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Plasmodium knowlesi

NOT Open Access | Detection of Plasmodium knowlesi using recombinase polymerase amplification (RPA) combined with SYBR Green I

May 19, 2020 - 15:40 -- NOT Open Access
Lai MY, Lau YL
Acta Tropica Volume 208, August 2020, 105511

In this study, recombinase polymerase amplification (RPA) combined with SYBR Green I was developed for the detection of Plasmodium knowlesi. Positive samples were indicated with a green color while negative samples were orange.

Malaria cross-sectional surveys identified asymptomatic infections of Plasmodium falciparum, Plasmodium vivax, and Plasmodium knowlesi in Surat Thani, a southern province of Thailand

May 19, 2020 - 14:35 -- Open Access
Shimizu S, Chotirat S, Nguitragool W, et al.
Int J Infect Dis. 2020 May 10:S1201-9712(20)30329-5

Malaria cross-sectional surveys are rarely conducted in very low transmission settings. This study aimed to determine the prevalence and risk factors of Plasmodium infection in a near-elimination setting in southern Thailand.

NOT Open Access | Two Genetically Distinct Plasmodium knowlesi Duffy Binding Protein Alpha Region II (PkDBPαII) Haplotypes Demonstrate Higher Binding Level to Fy(a+b+) Erythrocytes than Fy(a+b-) Erythrocytes

March 23, 2020 - 14:12 -- NOT Open Access
Liew CC, Lau YL, Fong MY, Cheong FW
Am J Trop Med Hyg. 2020 Mar 16

Invasion of human erythrocytes by merozoites of Plasmodium knowlesi involves interaction between the P. knowlesi Duffy binding protein alpha region II (PkDBPαII) and Duffy antigen receptor for chemokines (DARCs) on the erythrocytes. Information is scarce on the binding level of PkDBPαII to different Duffy antigens, Fya and Fyb.

NOT Open Access | Novel endochin-like quinolones exhibit potent in vitro activity against Plasmodium knowlesi but do not synergise with proguanil

March 2, 2020 - 15:06 -- NOT Open Access
van Schalkwyk DA, Riscoe MK, Pou S, Winter RW, Nilsen A, Duffey M, Moon RW, Sutherland CJ
Antimicrob Agents Chemother. 2020 Feb 24. pii: AAC.02549-19

Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome bc1 complex, a target critical to the survival of both liver and blood stage parasites, making these drugs useful as both prophylaxis and treatment. Recently, several derivatives of endochin have been optimised to produce novel quinolones that are active in vitro and in animal models.

NOT Open Access | Is the Epidemiology of Plasmodium knowlesi Changing, and What Does This Mean for Malaria Control in Southeast Asia?

January 20, 2020 - 16:31 -- NOT Open Access
Karunajeewa H, Berman J
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 368–369

It has long been clear that the “monkey-malaria” species, Plasmodium knowlesi, is capable of infecting humans. Its name comes from Robert Knowles, the British parasitologist who first demonstrated experimental monkey–human transmission and pioneered its use as “malaria therapy” for syphilis and leprosy from as early as 1932 [1].

Plasmodium knowlesi Malaria in Sabah, Malaysia, 2015-2017: Ongoing Increase in Incidence Despite Near-elimination of the Human-only Plasmodium Species

January 20, 2020 - 16:11 -- Open Access
Cooper DJ, Rajahram GS, Barber BE, et al.
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 361–367

Malaysia aims to eliminate malaria by 2020. However, while cases of Plasmodium falciparum and Plasmodium vivax have decreased substantially, the incidence of zoonotic malaria from Plasmodium knowlesi continues to increase, presenting a major challenge to regional malaria control efforts. Here we report incidence of all Plasmodium species in Sabah, including zoonotic P. knowlesi, during 2015–2017.

Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia

November 30, 2019 - 04:44 -- Open Access
Ahmed MA, Saif A, Quan FS
PLoS One. 2019 Nov 21;14(11):e0224743.

Human infections due to the monkey malaria parasite Plasmodium knowlesi are increasingly being reported from Malaysia. The parasite causes high parasitaemia, severe and fatal malaria in humans thus there is a need for urgent measures for its control.


NOT Open Access | Identification of Plasmodium knowlesi Merozoite Surface Protein-119 (PkMSP-119 ) novel binding peptides from a phage display library

November 19, 2019 - 06:38 -- NOT Open Access
Ting Goh X, Heng Chua K, Pin Kee B, Lim YAL
Trop Med Int Health. 2019 Nov 16

Plasmodium knowlesi, the fifth human malaria parasite, has caused mortality in humans. We aimed to identify P. knowlesi novel binding peptides through a random linear dodecapeptide phage display targeting the 19‐kDa fragment of Merozoite Surface Protein‐1 protein.

Plasmodium knowlesi clinical isolates from Malaysia show extensive diversity and strong differential selection pressure at the merozoite surface protein 7D (MSP7D)

May 3, 2019 - 17:21 -- Open Access
Md. Atique Ahmed and Fu-Shi Quan
Malaria Journal 2019 18:150, 29 April 2019


The high proportion of human cases due to the simian malaria parasite Plasmodium knowlesi in Malaysia is a cause of concern, as they can be severe and even fatal. Merozoite surface protein 7 (MSP7) is a multigene family which forms a non-covalent complex with MSP-1 prior to receptor-ligand recognition in Plasmodium falciparum and thus an important antigen for vaccine development. However, no study has been done in any of the ortholog family members in P. knowlesi from clinical samples. This study investigates the level of polymorphism, haplotypes, and natural selection acting at the pkmsp-7D gene in clinical samples from Malaysia.


Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

March 13, 2019 - 14:40 -- Open Access
Gael Davidson, Tock H. Chua, Angus Cook, Peter Speldewinde and Philip Weinstein
Malaria Journal 2019 18:66, 8 March 2019

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia.


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