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Plasmodium knowlesi

Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

March 13, 2019 - 14:40 -- Open Access
Author(s): 
Gael Davidson, Tock H. Chua, Angus Cook, Peter Speldewinde and Philip Weinstein
Reference: 
Malaria Journal 2019 18:66, 8 March 2019

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia.

Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study

February 6, 2019 - 15:50 -- Open Access
Author(s): 
Dorothy Wavinya Nyamai and Özlem Tastan Bishop
Reference: 
Malaria Journal 2019 18:34, 6 February 2019

This study showed that, despite, functional and structural conservation, Plasmodium aaRSs have key differences from the human homologues.

Laboratory challenges of Plasmodium species identification in Aceh Province, Indonesia, a malaria elimination setting with newly discovered P. knowlesi

December 12, 2018 - 16:12 -- Open Access
Author(s): 
Farah N. Coutrier, Yusrifar K. Tirta, Rintis Noviyanti, et al.
Reference: 
PLoS Negl Trop Dis 12(11): e0006924

The discovery of the life-threatening zoonotic infection Plasmodium knowlesi has added to the challenges of prompt and accurate malaria diagnosis and surveillance.

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Within-population genetic diversity and population structure of Plasmodium knowlesi merozoite surface protein 1 gene from geographically distinct regions of Malaysia and Thailand

December 4, 2018 - 14:47 -- Open Access
Author(s): 
Md Atique Ahmed, Ki-Back Chu, Indra Vythilingam and Fu-Shi Quan
Reference: 
Malaria Journal 2018 17:442, 29 November 2018

This study is the first to report on inter country genetic diversity and population structure of P. knowlesi based on msp1.

Diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia

July 31, 2018 - 15:29 -- Open Access
Author(s): 
Md Atique Ahmed, Yee Ling Lau and Fu-Shi Quan
Reference: 
Malaria Journal 2018 17:274, 27 July 2018

This study is the first to report on the genetic diversity and natural selection of full-length pktrap.

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In vitro invasion inhibition assay using antibodies against Plasmodium knowlesi Duffy binding protein alpha and apical membrane antigen protein 1 in human erythrocyte-adapted P. knowlesi A1-H.1 strain

July 31, 2018 - 15:28 -- Open Access
Author(s): 
Fauzi Muh, Seong-Kyun Lee, Mohammad Rafiul Hoque, Jin-Hee Han, Ji-Hoon Park, Egy Rahman Firdaus, Robert W. Moon, Yee Ling Lau and Eun-Taek Han
Reference: 
Malaria Journal 2018 17:272, 27 July 2018

These data provide support for the validation of in vitro growth inhibition assay using antibodies of DBPα and AMA1 in human-adapted P. knowlesi parasite PkA1-H.1 strain.

Exposure and infection to Plasmodium knowlesi in case study communities in Northern Sabah, Malaysia and Palawan, The Philippines

June 21, 2018 - 17:15 -- Open Access
Author(s): 
Kimberly M. Fornace, Lou S. Herman, Chris J. Drakeley, et al.
Reference: 
PLoS Negl Trop Dis 12(6): e0006432

This is the first study to describe serological exposure to P. knowlesi and associated risk factors within endemic communities.

Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure

June 21, 2018 - 17:14 -- Open Access
Author(s): 
Lou S. Herman, Kimberly Fornace, Kevin K. A. Tetteh, et al.
Reference: 
PLoS Negl Trop Dis 12(6): e0006457

The PkSERA3 antigen 2 had the highest relative variable importance in all models.

A dual colour fluorescence in situ hybridization (FISH) assay for identifying the zoonotic malaria parasite Plasmodium knowlesi with a potential application for the specific diagnosis of knowlesi malaria in peripheral-level laboratories of Southeast Asia

May 30, 2018 - 07:08 -- Open Access
Author(s): 
Jyotsna Shah, Akhila Poruri, Olivia Mark, Urmila Khadilka, Franziska Mohring, Robert W. Moon and Ranjan Ramasamy
Reference: 
Shah et al. Parasites & Vectors (2017) 10:342

Plasmodium knowlesi is primarily responsible for zoonotic malaria in several Southeast Asian countries. Precise identification of the parasite in the blood of patients presently relies on an expensive and elaborate PCR procedure because microscopic examination of blood and other available field identification techniques lack adequate specificity. 

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