Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia.
This study showed that, despite, functional and structural conservation, Plasmodium aaRSs have key differences from the human homologues.
The discovery of the life-threatening zoonotic infection Plasmodium knowlesi has added to the challenges of prompt and accurate malaria diagnosis and surveillance.
This is the first reported case of splenic rupture in P. knowlesi malaria infection.
This study is the first to report on inter country genetic diversity and population structure of P. knowlesi based on msp1.
This study is the first to report on the genetic diversity and natural selection of full-length pktrap.
These data provide support for the validation of in vitro growth inhibition assay using antibodies of DBPα and AMA1 in human-adapted P. knowlesi parasite PkA1-H.1 strain.
This is the first study to describe serological exposure to P. knowlesi and associated risk factors within endemic communities.
The PkSERA3 antigen 2 had the highest relative variable importance in all models.
Plasmodium knowlesi is primarily responsible for zoonotic malaria in several Southeast Asian countries. Precise identification of the parasite in the blood of patients presently relies on an expensive and elaborate PCR procedure because microscopic examination of blood and other available field identification techniques lack adequate specificity.