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NOT Open Access | Impact of malaria in pregnancy on risk of malaria in young children: systematic review and meta-analyses

March 30, 2020 - 10:19 -- NOT Open Access
Author(s): 
Park S, Nixon CE, Miller O, Choi NK, Kurtis JD, Friedman JF, Michelow IC
Reference: 
J Infect Dis. 2020 Mar 27. pii: jiaa139

Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy.

Validity and reliability of a Hausa language questionnaire assessing information, motivation and Behavioural skills for malaria prevention during pregnancy

March 25, 2020 - 14:51 -- Open Access
Author(s): 
Balami AD, Said SM, Zulkefli NM, Bachok N, Audu BM
Reference: 
BMC Public Health. 2020 Mar 24;20(1):384

Many studies on malaria knowledge, attitude and practice among pregnant women have been conducted in Hausa speaking communities in Nigeria. Despite this, no standard and uniform instrument for assessing this important public health problem has been developed in the Hausa language, even though it is widely spoken. The aim of this study was to develop and validate a questionnaire in Hausa language assessing information, motivation, and behavioural skills for malaria prevention during pregnancy.

Systematic review of statistical methods for safety data in malaria chemoprevention in pregnancy trials

March 24, 2020 - 11:42 -- Open Access
Author(s): 
Noel Patson, Mavuto Mukaka, Tobias Chirwa, et al.
Reference: 
Malaria Journal 2020 19:119, 20 March 2020

Drug safety assessments in clinical trials present unique analytical challenges. Some of these include adjusting for individual follow-up time, repeated measurements of multiple outcomes and missing data among others. Furthermore, pre-specifying appropriate analysis becomes difficult as some safety endpoints are unexpected. Although existing guidelines such as CONSORT encourage thorough reporting of adverse events (AEs) in clinical trials, they provide limited details for safety data analysis. The limited guidelines may influence suboptimal analysis by failing to account for some analysis challenges above. A typical example where such challenges exist are trials of anti-malarial drugs for malaria prevention during pregnancy. Lack of proper standardized evaluation of the safety of antimalarial drugs has limited the ability to draw conclusions about safety. Therefore, a systematic review was conducted to establish the current practice in statistical analysis for preventive antimalarial drug safety in pregnancy.

Why is WHO failing women with falciparum malaria in the first trimester of pregnancy?

March 17, 2020 - 12:53 -- Open Access
Author(s): 
McGready R, Nosten F, Barnes KI, Mokuolu O, White NJ
Reference: 
Lancet. 2020 Mar 7;395(10226):779

In the opening to WHO's World Malaria Report 2019, subtitled Leaving no one behind in the march to a malaria-free world, WHO's Director-General Tedros Adhanom Ghebreyesus noted that the scourge of malaria continues to strike hardest against pregnant women and children in Africa. The Director-General reported that “some 11 million pregnant women in sub-Saharan Africa were infected with malaria and, consequently, nearly 900 000 children were born with a low birthweight”. Furthermore, he noted that “Malaria in pregnancy compromises the mother's health and puts her at greater risk of death. It impacts the health of the fetus, leading to prematurity and low birthweight, major contributors to neonatal and infant mortality.”

Coverage and effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) on adverse pregnancy outcomes in the Mount Cameroon area, South West Cameroon

March 9, 2020 - 13:51 -- Open Access
Author(s): 
Judith K. Anchang-Kimbi, Laken N. Kalaji, Harry F. Mbacham, Godlove B. Wepnje, Tobias O. Apinjoh, Irene U. Ngole Sumbele, Jodie Dionne-Odom, Alan T. N. Tita and Eric A. Achidi
Reference: 
Malaria Journal 2020 19:100, 2 March 2020

Growing concerns about the waning efficacy of IPTp-SP warrants continuous monitoring and evaluation. This study determined coverage of IPTp-SP and compared the effectiveness of the 3-dose to 2-dose regimen on placental malaria (PM) infection and low birth weight (LBW) in the Mount Cameroon area.

A Randomized Controlled Trial of Three- versus Five-Day Artemether-Lumefantrine Regimens for Treatment of Uncomplicated Plasmodium falciparum Malaria in Pregnancy in Africa

March 2, 2020 - 14:01 -- Open Access
Author(s): 
Onyamboko MA, Hoglund RM, Lee SJ, Kabedi C, Kayembe D, Badjanga BB, Turner GDH, Jackson NV, Tarning J, McGready R, Nosten F, White NJ, Day NPJ, Fanello C
Reference: 
Antimicrob Agents Chemother. 2020 Feb 21;64(3). pii: e01140-19

Artemether-lumefantrine antimalarial efficacy in pregnancy could be compromised by reduced drug exposure. Population-based simulations suggested that therapeutic efficacy would be improved if the treatment duration was increased. We assessed the efficacy, tolerability, and pharmacokinetics of an extended 5-day regimen of artemether-lumefantrine compared to the standard 3-day treatment in 48 pregnant women and 48 nonpregnant women with uncomplicated falciparum malaria in an open-label, randomized clinical trial. Babies were assessed at birth and 1, 3, 6, and 12 months.

Bayesian Spatiotemporal Modeling of Routinely Collected Data to Assess the Effect of Health Programs in Malaria Incidence During Pregnancy in Burkina Faso

February 22, 2020 - 16:57 -- Open Access
Author(s): 
Rouamba T, Samadoulougou S, Tinto H, Alegana VA, Kirakoya-Samadoulougou F
Reference: 
Sci Rep. 2020 Feb 14;10(1):2618

Control of malaria in pregnancy (MiP) remains a major challenge in Burkina Faso. Surveillance of the burden due to MiP based on routinely collected data at a fine-scale level, followed by an appropriate analysis and interpretation, may be crucial for evaluating and improving the effectiveness of existing control measures. We described the spatio-temporal dynamics of MiP at the community-level and assessed health program effects, mainly community-based health promotion, results-based financing, and intermittent-preventive-treatment with sulphadoxine-pyrimethamine (IPTp-SP).

Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

January 24, 2020 - 14:45 -- Open Access
Author(s): 
Cutts JC, Agius PA, Zaw Lin, Powell R, Moore K, Draper B, Simpson JA, Fowkes FJI
Reference: 
BMC Med 18, 14 (2020)

In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) in the placenta. In subsequent pregnancies, women develop protective immunity to pregnancy-associated malaria and this has been hypothesized to be due to the acquisition of antibodies to the parasite variant surface antigen VAR2CSA. In this systematic review we provide the first synthesis of the association between antibodies to pregnancy-specific P. falciparum antigens and pregnancy and birth outcomes.

Use of a highly-sensitive rapid diagnostic test to screen for malaria in pregnancy in Indonesia

January 20, 2020 - 15:58 -- Open Access
Author(s): 
Vera T. Unwin, Rukhsana Ahmed, Emily R. Adams, et al.
Reference: 
Malaria Journal 2020 19:28, 16 January 2020

The sensitivity of rapid diagnostic tests (RDTs) for malaria is inadequate for detecting low-density, often asymptomatic infections, such as those that can occur when screening pregnant women for malaria. The performance of the Alere™ Ultra-sensitive Malaria Ag Plasmodium falciparum RDT (uRDT) was assessed retrospectively in pregnant women in Indonesia.

NOT Open Access | The economic burden of malaria in pregnancy: a cross-sectional study

January 7, 2020 - 14:02 -- NOT Open Access
Author(s): 
Onyia VU, Ughasoro MD, Onwujekwe OE
Reference: 
The Journal of Maternal-Fetal & Neonatal Medicine Volume 33, 2020 - Issue 1, Pages 92-95

Malaria in pregnancy carries a proven huge health burden; however, the economic challenges have not been properly evaluated in Nigeria.

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