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parasitaemia

Correlation of malaria parasitaemia with peripheral blood monocyte to lymphocyte ratio as indicator of susceptibility to severe malaria in Ghanaian children

November 15, 2018 - 15:10 -- Open Access
Author(s): 
Samuel Antwi-Baffour, Ransford Kyeremeh, Dorcas Buabeng, Jonathan Kofi Adjei, Claudia Aryeh, George Kpentey and Mahmood Abdulai Seidu
Reference: 
Malaria Journal 2018 17:419

The study comprised of 1629 (m = 896; f = 733) children up to 5 years presenting with clinical malaria as cases and 445 (m = 257; f = 188) apparently healthy children as controls. The results indicated that there was a significant positive correlation between the monocytes to lymphocytes ratio and the presence of parasites (p = 0.04) and the level of parasitaemia within the age group of 0–3 years (p = 0.02) and 4–5 years (p = 0.03).

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

August 22, 2016 - 16:24 -- Open Access
Author(s): 
James S. McCarthy, Mark Baker, Peter O'Rourke, Louise Marquart, Paul Griffin, Rob Hooft van Huijsduijnen and Jörg J. Möhrle
Reference: 
J. Antimicrob. Chemother. (2016) 71 (9): 2620-2627

These results confirm the antimalarial potential of artefenomel for use in a single-exposure combination therapy. The observations from this study support and will assist further clinical development of artefenomel.

Plasmodium falciparum parasitaemia and malaria among pregnant women at first clinic visit in the mount Cameroon Area

October 23, 2015 - 15:33 -- Open Access
Author(s): 
Judith K. Anchang-Kimbi, Vera Ngenwie Nkweti, Helen Ngum Ntonifor, Tobias O. Apinjoh, Rolland Bantar Tata, Hanesh Fru Chi and Eric Akum Achidi
Reference: 
BMC Infectious Diseases 2015, 15:439

This study investigated the prevalence and risk factors for P. falciparum infection and malaria among pregnant women reporting for first antenatal care (ANC) clinic visit in the mount Cameroon area.

High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparum parasitaemia in bioassays

October 30, 2014 - 16:50 -- Open Access
Author(s): 
Regis W Tiendrebeogo, Bright Adu, Susheel K Singh, Daniel Dodoo, Morten H Dziegiel, Benjamin Mordmüller, Issa Nébié, Sodiomon B Sirima, Michael Christiansen, Michael Theisen
Reference: 
Malaria Journal 2014, 13:412 (20 October 2014)

Here, a high-throughput, three-parameter (tri-colour) flow cytometry technique based on mitotracker red dye, the nucleic acid dye coriphosphine O (CPO) and the leucocyte marker CD45 for enumerating live parasites in bioassays was developed.

Multilevel and geo-statistical modeling of malaria risk in children of Burkina Faso

August 11, 2014 - 17:57 -- Open Access
Author(s): 
Samadoulougou S, Maheu-Giroux M, Kirakoya-Samadoulougou F, De Keukeleire M, Castro M, Robert A
Reference: 
Parasites & Vectors 2014, 7 :350 (29 July 2014)

The aims of this study were: i) to identify such individual, household, community, and climatic/environmental risk factors for malaria in children under five years of age, and ii) to produce a parasitaemia risk map of Burkina Faso.

Magnetic isolation of Plasmodium falciparum schizonts iRBCs to generate a high parasitaemia and synchronized in vitro culture

April 7, 2014 - 16:52 -- Open Access
Author(s): 
Mata-Cantero L, Lafuente MJ, Sanz L, Rodriguez MS
Reference: 
Malaria Journal 2014, 13 :112 (21 March 2014)

The described procedure allows obtaining a large scale synchronized parasite culture at a high parasitaemia with less manipulations than other methods previously described.

Patient-, health worker-, and health facility-level determinants of correct malaria case management at publicly funded health facilities in Malawi: results from a nationally representative health facility survey

February 26, 2014 - 16:42 -- Open Access
Author(s): 
Steinhardt LC, Chinkhumba J, Wolkon A, Luka M, Luhanga M, Sande J, Oyugi J, Ali D, Mathanga D, Skarbinski J
Reference: 
Malaria Journal 2014, 13 :64 (20 February 2014)

Among the 2,019 patients surveyed, 34% had confirmed malaria defined as presence of fever and parasitaemia on a reference blood smear. 

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Not Open Access | Single nucleotide polymorphisms of ADRB2 gene and their association with susceptibility for Plasmodium falciparum malaria and asthma in an Indian population

October 16, 2013 - 18:41 -- NOT Open Access
Author(s): 
Abdul Vahab Saadi, Himanshu Gupta, Kapaettu Satyamoorthy, et al.
Reference: 
Infection, Genetics and Evolution, Volume 20, December 2013, Pages 140-147
MalariaWorld

The study provides evidence for the proposed role of β2-adrenoreceptor mediated molecular mechanisms in etiology of malaria, as well as asthma disease and drug response, for further clinical and therapeutic application studies.

Prevalence of congenital malaria in high-risk Ghanaian newborns: a cross-sectional study

January 15, 2013 - 14:50 -- Open Access
Author(s): 
Enweronu-Laryea CC, Adjei GO, Mensah B, Duah N, Quashie NB
Reference: 
Malaria Journal 2013, 12:17 (11 January 2013)
MalariaWorld

The reported prevalence of congenital malaria in sub-Saharan Africa is variable (0 - 46%). Even though the clinical significance of congenital malaria parasitaemia is uncertain, anti-malarial drugs are empirically prescribed for sick newborns by frontline health care workers.

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Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda

December 31, 2012 - 10:55 -- Open Access
Author(s): 
Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G
Reference: 
Malaria Journal 2012, 11:435 (28 December 2012)
MalariaWorld

Reported compliance with LLINs was 98% based on monthly routine evaluations. A total of 1,633 episodes of malaria were observed, with a median incidence of 5.3 per person-year (PPY).

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