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antimalarials

NOT Open Access | Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model—A Unifying Proposal for Drug Action

December 6, 2012 - 09:19 -- NOT Open Access
Author(s): 
Richard K. Haynes, Kwan-Wing Cheu, Diego Monti, et al.
Reference: 
ChemMedChem, Volume 7, Issue 12, pages 2204–2226, December 2012
MalariaWorld

Artemisinins are proposed to act in the malaria parasite cytosol by oxidizing dihydroflavin cofactors of redox-active flavoenzymes, and under aerobic conditions by inducing their autoxidation.

Medical Treatment: 

ATP and luciferase assays to determine the rate of drug action in in vitro cultures of Plasmodium falciparum

November 12, 2012 - 09:40 -- Open Access
Author(s): 
Khan T, van Brummelen AC, Parkinson CJ, Hoppe HC
Reference: 
Malaria Journal 2012, 11:369 (7 November 2012)
MalariaWorld

ATP levels and luciferase activity respond rapidly to incubation with anti-malarial drugs and provide quantitative read-outs to detect the appearance and magnitude of drug-induced stress in cultured parasites.

Exploring health providers' and community perceptions and experiences with malaria tests in South-East Nigeria: a critical step towards appropriate treatment

November 12, 2012 - 09:36 -- Open Access
Author(s): 
Ezeoke OP, Ezumah NN, Chandler CC, Magham-Jefferies LJ, Onwujekwe OE, Wiseman V, Uzochukwu BS
Reference: 
Malaria Journal 2012, 11:368 (6 November 2012)
MalariaWorld

The results highlight important areas of intervention to promote appropriate malaria treatment.

Country: 
Medical Treatment: 

NOT Open Access | Trends in Antimalarial Prescriptions in Australia, 2005 to 2009

November 12, 2012 - 09:00 -- NOT Open Access
Author(s): 
Peter A. Leggat
Reference: 
Journal of Travel Medicine, Volume 19, Issue 6, pages 357–360, December 2012
MalariaWorld

The prescription of antimalarials in Australia was consistent with the national guidelines with the most commonly prescribed antimalarials being atovaquone plus proguanil, mefloquine, and most likely doxycycline.

Continent: 

NOT Open Access | Linear and cyclic dipeptides with antimalarial activity

November 11, 2012 - 12:42 -- NOT Open Access
Author(s): 
Lemuel Pérez-Picaso, Horacio F. Olivo, Rocío Argotte-Ramos, María Rodríguez-Gutiérrez, María Yolanda Rios
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 23, 1 December 2012, Pages 7048–7051

Several natural and synthetic polypeptides possess important antimalarial activity.

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