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antimalarials

NOT Open Access | Improving the Role and Contribution of Pharmacokinetic Analyses in Antimalarial Drug Clinical Trials

September 19, 2014 - 14:58 -- NOT Open Access
Author(s): 
Katherine Kay, Eva Maria Hodel, and Ian M. Hastings
Reference: 
Antimicrob. Agents Chemother. October 2014 vol. 58 no. 10 5643-5649

It is now World Health Organization (WHO) policy that drug concentrations on day 7 be measured as part of routine assessment in antimalarial drug efficacy trials.

Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity

September 19, 2014 - 14:30 -- Open Access
Author(s): 
Rijpma SR, van den Heuvel JJ, van der Velden M, Sauerwein RW, Russel FG, Koenderink JB
Reference: 
Malaria Journal 2014, 13 :359 (13 September 2014)

Atovaquone and quinine significantly inhibit BCRP- and P-gp- mediated transport at concentrations within the clinically relevant prophylactic and therapeutic range.

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Women's Access and Provider Practices for the Case Management of Malaria during Pregnancy: A Systematic Review and Meta-Analysis

September 4, 2014 - 11:46 -- Open Access
Author(s): 
Jenny Hill, Lauren D'Mello-Guyett, Jenna Hoyt, Anna M. van Eijk, Feiko O. ter Kuile, Jayne Webster
Reference: 
PLoS Med 11(8): e1001688

A systematic assessment of the extent of substandard case management practices of malaria in pregnancy is required, as well as quality improvement interventions that reach all providers administering antimalarial drugs in the community.

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Safety of artemether-lumefantrine exposure in first trimester of pregnancy: an observational cohort

June 10, 2014 - 12:36 -- Open Access
Author(s): 
Mosha D, Mazuguni F, Mrema S, Sevene E, Abdulla S, Genton B
Reference: 
Malaria Journal 2014, 13 :197 (27 May 2014)

Even with this caveat, a change of policy from quinine to AL for the treatment of uncomplicated malaria during the whole pregnancy period could be already envisaged.

NOT Open Access | Antimalarial Efficacy of Hydroxyethylapoquinine (SN-119) and Its Derivatives

January 30, 2014 - 13:51 -- NOT Open Access
Author(s): 
Natalie G. Sanders, David J. Meyers, and David J. Sullivan
Reference: 
Antimicrob. Agents Chemother. February 2014 vol. 58 no. 2 820-827

Quinine and other cinchona-derived alkaloids, although recently supplanted by the artemisinins (ARTs), continue to be important for treatment of severe malaria.

NOT Open Access | In vivo Antimalarial Activity of a Labdane Diterpenoid from the Leaves of Otostegia integrifolia Benth

December 17, 2013 - 08:08 -- NOT Open Access
Author(s): 
Abyot Endale, Daniel Bisrat, Abebe Animut, Franz Bucar and Kaleab Asres
Reference: 
Phytotherapy Research, Volume 27, Issue 12, pages 1805–1809, December 2013

In Ethiopian traditional medicine, the leaves of Otostegia integrifolia Benth. are used for the treatment of several diseases including malaria.

The impact of rapid malaria diagnostic tests upon anti-malarial sales in community pharmacies in Gwagwalada, Nigeria

November 6, 2013 - 08:12 -- Open Access
Author(s): 
Ikwuobe JO, Faragher BE, Alawode G, Lalloo DG
Reference: 
Malaria Journal 2013, 12 :380 (30 October 2013)
MalariaWorld

The study highlights the enormous potential for improving appropriate prescription of anti-malarials in pharmacies and preventing unnecessary use of artemisinin combination therapy (ACT).

NOT Open Access | In vivo antimalarial activity of Trichilia megalantha harms extracts and fractions in animal models

August 12, 2013 - 12:39 -- NOT Open Access
Author(s): 
Dorcas A. Fadare, Oyindamola O. Abiodun & Edith O. Ajaiyeoba
Reference: 
Parasitology Research, August 2013, Volume 112, Issue 8, pp 2991-2995
MalariaWorld

The crude methanol extracts of leaf, stem bark, root bark and stem bark fractions of Trichilia megalantha (Meliaceae) were screened for in vivo antimalarial activities in mice against a chloroquine resistant Plasmodium berghei berghei ANKA clone using the 4-day suppressive test procedure.

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NOT Open Access | High-level semi-synthetic production of the potent antimalarial artemisinin

April 25, 2013 - 07:01 -- NOT Open Access
Author(s): 
C. J. Paddon, P. J. Westfall, J. D. Newman, et al.
Reference: 
Nature, 496, 528–532, (25 April 2013)
MalariaWorld

In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths1.

NOT Open Access | Molecular monitoring of antimalarial drug resistance among Plasmodium falciparum field isolates from Odisha, India

February 27, 2013 - 12:35 -- NOT Open Access
Author(s): 
Sasmita Kumari Das Sutar, Gunanidhi Dhangadamajhi, Shantanu Kumar Kar, Manoranjan Ranjit
Reference: 
Acta Tropica, Volume 126, Issue 1, April 2013, Pages 84–87
MalariaWorld

In the absence of definite marker for artemisinin (ART) resistance, molecular monitoring of its partner drug sulfadoxine pyrimethamine (SP) in artemisinin based combination therapy (ACTs) together with chloroquine (CQ) for which ART is negatively correlated, may predict the effectiveness of ACT.

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