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antimalarials

NOT Open Access | Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents

April 14, 2015 - 18:23 -- NOT Open Access
Author(s): 
Sai Kumar Chakka, Mohammad Kalamuddin, Srividhya Sundararaman, Lianhu Wei, Sourabh Mundra, Radhakrishnan Mahesh, Pawan Malhotra, Asif Mohmmed, Lakshmi P. Kotra
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 9, 1 May 2015, Pages 2221–2240

Falcipain-2 is a papain family cysteine protease and an emerging antimalarial drug target.

NOT Open Access | Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice

April 14, 2015 - 18:21 -- NOT Open Access
Author(s): 
Igor M. Opsenica, Tatjana Ž. Verbić, Mikloš Tot, Richard J. Sciotti, Brandon S. Pybus, Olgica Djurković-Djaković, Ksenija Slavić, Bogdan A. Šolaja
Reference: 
Bioorganic & Medicinal Chemistry Volume 23, Issue 9, 1 May 2015, Pages 2176–2186

We herein report the design and synthesis of a novel series of thiophene- and furan-based aminoquinoline derivatives which were found to be potent antimalarials and inhibitors of β-hematin polymerization.

Medical Treatment: 

NOT Open Access | An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents

April 6, 2015 - 08:33 -- NOT Open Access
Author(s): 
Braulio Insuasty, Juan Ramirez, Justo Cobo, et al.
Reference: 
European Journal of Medicinal Chemistry Volume 93, 26 March 2015, Pages 401–413

A new series of chalcones 5a–f were synthesized from caffeine-based aldehyde 3 and substituted acetophenones 4a–f.

Post-marketing surveillance of anti-malarial medicines used in Malawi

March 31, 2015 - 17:22 -- Open Access
Author(s): 
Ibrahim Chikowe, Dorcas Osei-Safo, Jerry Harrison, Daniel Y Konadu, Ivan Addae-Mensah
Reference: 
Malaria Journal 2015, 14:127 (25 March 2015)

The results suggest the existence of substandard anti-malarial medicines in Malawi.

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The impact of providing rapid diagnostic malaria tests on fever management in the private retail sector in Ghana: a cluster randomized trial

March 6, 2015 - 13:54 -- Open Access
Author(s): 
Evelyn K Ansah, Solomon Narh-Bana, Harriet Affran-Bonful, Constance Bart-Plange, Bonnie Cundill, Margaret Gyapong, Christopher J M Whitty
Reference: 
BMJ 2015;350:h1019

To examine the impact of providing rapid diagnostic tests for malaria on fever management in private drug retail shops where most poor rural people with fever present, with the aim of reducing current massive overdiagnosis and overtreatment of malaria.

NOT Open Access | First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

January 28, 2015 - 16:21 -- NOT Open Access
Author(s): 
Shirin Bruderer, Noémie Hurst, Ruben de Kanter, Tommaso Miraval, Thomas Pfeifer, Yves Donazzolo, and Jasper Dingemanse
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 935-942

Emerging resistance to antimalarial agents raises the need for new drugs.

NOT Open Access | Antimalarial chemotherapy: Orally curative artemisinin-derived trioxane dimer esters

January 7, 2015 - 09:23 -- NOT Open Access
Author(s): 
Ryan C. Conyers, Jennifer R. Mazzone, Abhai K. Tripathi, David J. Sullivan, Gary H. Posner
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 25, Issue 2, 15 January 2015, Pages 245–248

Eight new artemisinin-derived trioxane dimer esters 5 have been prepared and tested for antimalarial efficacy in malaria-infected mice.

NOT Open Access | Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Malaria in Children in Zaire and Uíge Provinces, Angola

December 31, 2014 - 06:33 -- NOT Open Access
Author(s): 
Mateusz M. Plucinski, Eldin Talundzic, Venkatachalam Udhayakumar, et al.
Reference: 
Antimicrob. Agents Chemother. January 2015 vol. 59 no. 1 437-443

The development of resistance to antimalarials is a major challenge for global malaria control. Artemisinin-based combination therapies, the newest class of antimalarials, are used worldwide but there have been reports of artemisinin resistance in Southeast Asia.

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Medical Treatment: 

Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial

October 1, 2014 - 17:53 -- Open Access
Author(s): 
Raquel González, Meghna Desai, Clara Menéndez, et al.
Reference: 
PLoS Med 11(9): e1001735.

We studied the safety and efficacy of mefloquine (MQ) in women receiving CTXp and long-lasting insecticide treated nets (LLITNs).

Not Open Access | Defining the biology component of the drug discovery strategy for malaria eradication

September 23, 2014 - 17:15 -- NOT Open Access
Author(s): 
Didier Leroy, Brice Campo, Xavier C. Ding, Jeremy N. Burrows, Stéphanie Cherbuin
Reference: 
Trends in Parasitology, Volume 30, Issue 10, October 2014, Pages 478-490

Finally, by assessing cross resistance and generating drug resistance in the laboratory, it is expected that new medicines with acceptable resistance profiles will be forthcoming.

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