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"We can't handle things we don't know about": perceived neurorehabilitation challenges for Malawian paediatric cerebral malaria survivors

November 4, 2020 - 14:44 -- Open Access
Author(s): 
Boubour A, Mboma S, Võ T, Birbeck GL, Seydel KB, Mallewa M, Chinguo D, Gladstone M, Mohamed S, Thakur KT
Reference: 
BMC Pediatr. 2020 Nov 3;20(1):503

We sought to identify perceptions of neurorehabilitation challenges for paediatric cerebral malaria (CM) survivors post-hospital discharge at Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi.

Malaria in children and women of childbearing age: infection prevalence, knowledge and use of malaria prevention tools in the province of Nyanga, Gabon

November 4, 2020 - 10:00 -- Open Access
Author(s): 
Roméo Karl Imboumy-Limoukou, Sydney Maghendji-Nzondo, Jean-Bernard Lekana-Douki, et al.
Reference: 
Malaria Journal 2020 19:387, 2 November 2020

There is little information on the social perception of malaria and the use of preventative measures in Gabon, especially in rural areas. Adequate knowledge of malaria prevention and control can help in reducing the burden of malaria among vulnerable groups, particularly pregnant women and children under 5 years old living in malaria-endemic settings. This study was designed to assess the prevalence of malaria and the knowledge and attitude towards this disease in households in Nyanga Province.

Malaria and risk of lymphoid neoplasms and other cancer: a nationwide population-based cohort study

November 4, 2020 - 09:30 -- Open Access
Author(s): 
Wyss K, Granath F, Wångdahl A, Djärv T, Fored M, Naucler P, Färnert A
Reference: 
BMC Med. 2020 Oct 30;18(1):296

Malaria is associated with Burkitt lymphoma among children in Sub-Saharan Africa. No longitudinal studies have assessed the long-term risk of other lymphoma or cancer overall. Here, we investigated the risk of lymphoid neoplasms and other cancer after malaria.

The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study

November 3, 2020 - 14:55 -- Open Access
Author(s): 
Ackerman H, Ayestaran A, Casals-Pascual C, et al.
Reference: 
Lancet Haematol. 2020 Nov;7(11):e789-e797

Infection with Plasmodium falciparum leads to severe malaria and death in approximately 400 000 children each year in sub-Saharan Africa. Blood transfusion might benefit some patients with malaria but could potentially harm others. The aim of this study was to estimate the association between transfusion and death among children admitted to hospital with P falciparum malaria.

Estimating the optimal interval between rounds of indoor residual spraying of insecticide using malaria incidence data from cohort studies

October 28, 2020 - 09:25 -- Open Access
Author(s): 
Mugenyi L, Nankabirwa JI, Arinaitwe E, Rek J, Hens N, Kamya M, Dorsey G
Reference: 
PLoS One. 2020 Oct 23;15(10):e0241033

Indoor residual spraying (IRS) reduces vector densities and malaria transmission, however, the most effective spraying intervals for IRS have not been well established. We estimated the optimal timing interval for IRS using a statistical approach.

Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H

October 22, 2020 - 15:45 -- Open Access
Author(s): 
M. Andreína Pacheco, Kristan A. Schneider, Qiuying Cheng, Elly O. Munde, Caroline Ndege, Clinton Onyango, Evans Raballah, Samuel B. Anyona, Collins Ouma, Douglas J. Perkins and Ananias A. Escalante
Reference: 
Malaria Journal 2020 19:378, 22 October 2020

Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and dhps (Pfdhps) genes confer resistance to pyrimethamine and sulfadoxine, respectively. Here, the frequencies of SP resistance-associated mutations from 2005 to 2018 were compared in samples from Kenyan children with malaria residing in a holoendemic transmission region.

A cohort study to identify risk factors for Plasmodium falciparum infection in Burkinabe children: implications for other high burden high impact countries

October 20, 2020 - 16:24 -- Open Access
Author(s): 
Jean Baptiste Yaro, Alphonse Ouedraogo, Anne L. Wilson, et al.
Reference: 
Malaria Journal 2020 19:371, 16 October 2020

Progress in controlling malaria has stalled in recent years. Today the malaria burden is increasingly concentrated in a few countries, including Burkina Faso, where malaria is not declining. A cohort study was conducted to identify risk factors for malaria infection in children in southwest Burkina Faso, an area with high insecticide-treated net (ITN) coverage and insecticide-resistant vectors.

Comparison of leucocyte profiles between healthy children and those with asymptomatic and symptomatic Plasmodium falciparum infections

October 13, 2020 - 12:39 -- Open Access
Author(s): 
Diana Ahu Prah, Linda Eva Amoah, Matthew P. Gibbins, Yaw Bediako, Aubrey J. Cunnington, Gordon A. Awandare and Julius Clemence R. Hafalla
Reference: 
Malaria Journal 2020 19:364, 9 October 2020

The immune mechanisms that determine whether a Plasmodium falciparum infection would be symptomatic or asymptomatic are not fully understood. Several studies have been carried out to characterize the associations between disease outcomes and leucocyte numbers. However, the majority of these studies have been conducted in adults with acute uncomplicated malaria, despite children being the most vulnerable group.

Severe malaria in Cameroon: Pattern of disease in children at the Yaounde Gynaeco-Obstetric and Pediatric hospital

October 7, 2020 - 16:07 -- Open Access
Author(s): 
Chiabi A, Djimafo ANM, Nguefack S, Mah E, Nguefack Dongmo F, Angwafo F 3rd
Reference: 
J Infect Public Health. 2020 Oct;13(10):1469-1472

Malaria is the most widely spread parasitic disease in the world, especially in the tropics affecting mostly children and pregnant women. In children, mostly under-fives carry the heaviest burden in terms of morbidity and mortality. The aim of this study was to determine the epidemiological and clinical aspects, and outcome of children 3 months to 15 years old with severe malaria at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH), a referral hospital in Yaounde, Cameroon.

Time for pragmatic, prospective clinical trials to determine the role of empirical antibacterial therapy in critically ill adults hospitalised with malaria

October 6, 2020 - 12:56 -- Open Access
Author(s): 
Hanson J, Nyein PP, Aung NM, Kyi MM
Reference: 
Int J Infect Dis. 2020 Oct 2:S1201-9712(20)32188-3

Children with severe falciparum malaria in malaria-endemic regions are predisposed to developing life-threatening bacterial co-infection. International guidelines therefore recommend empirical broad-spectrum antibacterial therapy in these children. Few studies have examined co-infection in adults, although it has been believed to be relatively rare; anti-bacterial therapy is therefore not routinely recommended in adults.

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