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Relationship between blood Lead status and anemia in Ugandan children with malaria infection

November 18, 2020 - 11:03 -- Open Access
Mukisa A, Kasozi D, Aguttu C, Vuzi PC, Kyambadde J
BMC Pediatr. 2020 Nov 14;20(1):521

In Uganda, childhood anemia remains a health challenge and is associated with malaria infection as well as iron deficiency. Iron deficiency is intertwined with nutritional status, age and other comorbidities including helminths and Lead toxicity. Environmental Lead levels accounts for one’s blood Lead (BL) levels. Blood Lead competitively blocks iron absorption, inhibits hemoglobin (Hb) biosynthesis and elevates free erythrocyte protoporphyrin (FEP) levels. Lead toxicity’s contribution towards anemia pathogenesis, especially during malaria infection has not been studied. Concomitant exposure to both malaria infection and Lead pollution, exacerbates the anemia status. This study therefore aimed at expounding the anemia status of these Ugandan children aged under 5years who are exposed to both malaria infection and environmental Lead pollution.

Sero-epidemiological evaluation of malaria transmission in The Gambia before and after mass drug administration

November 17, 2020 - 13:11 -- Open Access
Wu L, Mwesigwa J, Affara M, Drakeley C, et al.
BMC Med. 2020 Nov 13;18(1):331

As The Gambia aims to achieve malaria elimination by 2030, serological assays are a useful surveillance tool to monitor trends in malaria incidence and evaluate community-based interventions.

NOT Open Access | Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria

November 11, 2020 - 14:34 -- NOT Open Access
Villaverde C, Namazzi R, Shabani E, Park GS, Datta D, Hanisch B, Opoka RO, John CC
J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):580-586

Our prior study findings suggest that Plasmodium falciparum is the cause of disease in both malaria retinopathy-positive (RP) and most retinopathy-negative (RN) cerebral malaria (CM), and that absence of retinopathy and decreased disease severity in RN CM may be due to shorter duration of illness, lower parasite biomass, and decreased var gene expression in RN compared to RP CM. In the present study, we assessed the pathophysiology of RP and RN CM.

NOT Open Access | Artemisinin Activity in Red Blood Cells from Anemic Children

November 11, 2020 - 14:03 -- NOT Open Access
Joof F, Goheen MM, Cerami C
Am J Trop Med Hyg. 2020 Nov 9

Artemisinin combination therapies are the current frontline therapy for falciparum malaria. Artemisinin is activated by heme iron, and the consequent production of reactive oxygen species and carbon-centered radicals results in rapid parasite clearance. Red blood cells (RBCs) from anemic iron-deficient individuals have decreased levels of heme, and such deficiencies are highly prevalent among children and pregnant women in malaria-endemic countries.

Geostatistical analysis and mapping of malaria risk in children of Mozambique

November 10, 2020 - 15:02 -- Open Access
Ejigu BA
PLoS One. 2020 Nov 9;15(11):e0241680

Malaria remains one of the most prevalent infectious diseases in the tropics and subtropics, and Mozambique is not an exception. To design geographically targeted and effective intervention mechanisms of malaria, an up-to-date map that shows the spatial distribution of malaria is needed. This study analyzed 2018 Mozambique Malaria Indicator Survey using geostatistical methods to: i) explore individual, household, and community-level determinants of malaria in under-five children, ii) prepare a malaria prevalence map in Mozambique, and iii) produce prediction prevalence maps and exceedence probability across the country.

Copula geoadditive modelling of anaemia and malaria in young children in Kenya, Malawi, Tanzania and Uganda

November 10, 2020 - 13:46 -- Open Access
Roberts DJ, Zewotir T
J Health Popul Nutr. 2020 Nov 6;39(1):8

Anaemia and malaria are the leading causes of sub-Saharan African childhood morbidity and mortality. This study aimed to explore the complex relationship between anaemia and malaria in young children across the districts or counties of four contiguous sub-Saharan African countries, namely Kenya, Malawi, Tanzania and Uganda, while accounting for the effects of socio-economic, demographic and environmental factors. Geospatial maps were constructed to visualise the relationship between the two responses across the districts of the countries.

Repeated sampling improved the sensitivity of malaria microscopy in children under six years

November 7, 2020 - 12:46 -- Open Access
Aninagyei E
BMC Res Notes. 2020 Nov 4;13(1):508

Microscopy remains the gold standard for identification of malaria parasites. However, the sensitivity of malaria microscopy is low. This study evaluated the impact of repeated sampling up to 12 h in 177 children < 6 years with suspected malaria.

Prevalence and Risk Factors Associated with Malaria among Children Aged Six Months to 14 Years Old in Rwanda: Evidence from 2017 Rwanda Malaria Indicator Survey

November 4, 2020 - 15:13 -- Open Access
Habyarimana F, Ramroop S
Int J Environ Res Public Health. 2020 Oct 30;17(21):E7975

Malaria is a major public health risk in Rwanda where children and pregnant women are most vulnerable. This infectious disease remains the main cause of morbidity and mortality among children in Rwanda. The main objectives of this study were to assess the prevalence of malaria among children aged six months to 14 years old in Rwanda and to identify the factors associated with malaria in this age group.

"We can't handle things we don't know about": perceived neurorehabilitation challenges for Malawian paediatric cerebral malaria survivors

November 4, 2020 - 14:44 -- Open Access
Boubour A, Mboma S, Võ T, Birbeck GL, Seydel KB, Mallewa M, Chinguo D, Gladstone M, Mohamed S, Thakur KT
BMC Pediatr. 2020 Nov 3;20(1):503

We sought to identify perceptions of neurorehabilitation challenges for paediatric cerebral malaria (CM) survivors post-hospital discharge at Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi.

Malaria in children and women of childbearing age: infection prevalence, knowledge and use of malaria prevention tools in the province of Nyanga, Gabon

November 4, 2020 - 10:00 -- Open Access
Roméo Karl Imboumy-Limoukou, Sydney Maghendji-Nzondo, Jean-Bernard Lekana-Douki, et al.
Malaria Journal 2020 19:387, 2 November 2020

There is little information on the social perception of malaria and the use of preventative measures in Gabon, especially in rural areas. Adequate knowledge of malaria prevention and control can help in reducing the burden of malaria among vulnerable groups, particularly pregnant women and children under 5 years old living in malaria-endemic settings. This study was designed to assess the prevalence of malaria and the knowledge and attitude towards this disease in households in Nyanga Province.


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