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NOT Open Access | Delayed iron does not alter cognition or behavior among children with severe malaria and iron deficiency

May 14, 2020 - 12:28 -- NOT Open Access
Ssemata AS, Hickson M, Ssenkusu JM, Cusick SE, Nakasujja N, Opoka RO, Kroupina M, Georgieff MK, Bangirana P, John CC
Pediatr Res. 2020 May 13

Malaria and iron deficiency (ID) in childhood are both associated with cognitive and behavioral dysfunction. The current standard of care for children with malaria and ID is concurrent antimalarial and iron therapy. Delaying iron therapy until inflammation subsides could increase iron absorption but also impair cognition.

A novel vaccine target for malaria

May 13, 2020 - 13:46 -- Open Access
Wrighton KH
Nat Rev Microbiol. 2020 May 6

Malaria is a leading cause of death in children; however, developing an effective vaccine has been challenging. Raj et al. now show that Plasmodium falciparum glutamic-acid-rich protein (PfGARP), an 80 kDa antigen expressed on the surface of erythrocytes infected by P. falciparum, is a malaria vaccine candidate for specifically targeting the blood stage of P. falciparum.

Severe malaria in Cameroon: Pattern of disease in children at the Yaounde Gynaeco-Obstetric and Pediatric hospital

May 5, 2020 - 13:11 -- Open Access
Chiabi A, Djimafo ANM, Nguefack S, Mah E, Nguefack Dongmo F, Angwafo F
J Infect Public Health. 2020 Apr 29. pii: S1876-0341(20)30393-2

Malaria is the most widely spread parasitic disease in the world, especially in the tropics affecting mostly children and pregnant women. In children, mostly under-fives carry the heaviest burden in terms of morbidity and mortality. The aim of this study was to determine the epidemiological and clinical aspects, and outcome of children 3 months to 15 years old with severe malaria at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH), a referral hospital in Yaounde, Cameroon.

Central Nervous System Virus Infection in African Children with Cerebral Malaria

April 29, 2020 - 09:41 -- Open Access
Postels DG, Osei-Tutu L, Wilson MR, et al.
Am J Trop Med Hyg. 2020 Apr 27

We aimed to identify the contribution of central nervous system (CNS) viral coinfection to illness in African children with retinopathy-negative or retinopathy-positive cerebral malaria (CM). We collected cerebrospinal fluid (CSF) from 272 children with retinopathy-negative or retinopathy-positive CM and selected CSF from 111 of these children (38 retinopathy positive, 71 retinopathy negative, 2 retinopathy unknown) for analysis by metagenomic next-generation sequencing.

Effects of Biannual Azithromycin Mass Drug Administration on Malaria in Malawian Children: A Cluster-Randomized Trial

April 29, 2020 - 09:13 -- Open Access
Hart JD, Samikwa L, Sikina F, Kalua K, Keenan JD, Lietman TM, Burr SE, Bailey RL
Am J Trop Med Hyg. 2020 Apr 27

Reductions in malaria morbidity have been reported following azithromycin mass drug administration (MDA) for trachoma. The recent MORDOR trial reported a reduction in child mortality following biannual azithromycin MDA. Here, we investigate the effects of azithromycin MDA on malaria at the MORDOR-Malawi study site. A cluster-randomized double-blind placebo-controlled trial, with 15 clusters per arm, was conducted. House-to-house census was updated biannually, and azithromycin or placebo syrup was distributed to children aged 1–59 months for a total of four biannual distributions.

Reducing mortality from severe malaria in Sierra Leonean children by applying the World Health Organization's standard malarial protocol with additional sublingual glucose: A continuous quality improvement report

April 29, 2020 - 05:39 -- Open Access
Oxner A, Vellanki M, Kahn R, et al.
Int J Infect Dis. 2020 Apr 24. pii: S1201-9712(20)30262-9

Observational study comparing the mortality rate from malaria before and after the intervention.

Assessment of platelet indices and platelet activation markers in children with Plasmodium falciparum malaria

April 13, 2020 - 13:44 -- Open Access
Renate Asare, Clement Opoku-Okrah, Michael Frimpong, et al.
Malaria Journal 2020 19:143, 8 April 2020

Plasmodium falciparum malaria remains one of the world’s major infectious diseases that cause most morbidity and mortality, particularly in children. In Ghana, most children below the ages of 5 years depending on the severity of the infection often lose their lives. However, it is still debatable why infection with falciparum malaria contributes to thrombocytopenia.

A novel population of memory-activated natural killer cells associated with low parasitaemia in Plasmodium falciparum-exposed sickle-cell trait children

April 10, 2020 - 17:07 -- Open Access
Loiseau C, Doumbo OK, Traore B, Brady JL, Proietti C, de Sousa KP, Crompton PD, Doolan DL
Clin Transl Immunology. 2020 Apr 2;9(4):e1125

The sickle‐cell trait phenotype is associated with protection from malaria. Multiple molecular mechanisms have been proposed to explain this protection, but the role of the host immune system has been poorly investigated. We hypothesised that cellular immunity to malaria may develop differently in sickle‐cell trait children (HbAS) and children with normal haemoglobin (HbAA) repeatedly exposed to Plasmodium falciparum (Pf).

NOT Open Access | Acute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomes

April 7, 2020 - 06:13 -- NOT Open Access
Oshomah-Bello EO, Esezobor CI, Solarin AU, Njokanma FO
J Trop Pediatr. 2020 Apr 1;66(2):218-225

The prevalence of acute kidney injury (AKI) in children with severe malaria in sub-Saharan African may have been underestimated. The study aimed to determine the prevalence of AKI in children with severe malaria and its association with adverse hospital outcomes.

NOT Open Access | Impact of malaria in pregnancy on risk of malaria in young children: systematic review and meta-analyses

March 30, 2020 - 10:19 -- NOT Open Access
Park S, Nixon CE, Miller O, Choi NK, Kurtis JD, Friedman JF, Michelow IC
J Infect Dis. 2020 Mar 27. pii: jiaa139

Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy.


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