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stephensi

Heparin Administered to Anopheles in Membrane Feeding Assays Blocks Plasmodium Development in the Mosquito

August 5, 2020 - 16:24 -- Open Access
Author(s): 
Lantero E, Fernandes J, Aláez-Versón CR, Gomes J, Silveira H, Nogueira F, Fernàndez-Busquets X
Reference: 
Biomolecules. 2020 Aug 1;10(8):E1136

Innovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosquitoes.

Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi

April 29, 2019 - 13:13 -- Open Access
Author(s): 
Sakineh Pirahmadi, Sedigheh Zakeri, Akram A. Mehrizi, Navid D. Djadid, Abbas-Ali Raz, Jafar J. Sani, Ronak Abbasi and Zahra Ghorbanzadeh
Reference: 
Malaria Journal 2019 18:146, 24 April 2019

Plasmodium falciparum parasite is the most deadly species of human malaria, and the development of an effective vaccine that prevents P. falciparum infection and transmission is a key target for malarial elimination and eradication programmes. P. falciparum cell-traversal protein for ookinetes and sporozoites (PfCelTOS) is an advanced vaccine candidate. A comparative study was performed to characterize the immune responses in BALB/c mouse immunized with Escherichia coli-expressed recombinant PfCelTOS (rPfCelTOS) in toll-like receptor (TLR)-based adjuvants, CpG and Poly I:C alone or in combination (CpG + Poly I:C), followed by the assessment of transmission-reducing activity (TRA) of anti-rPfCelTOS antibodies obtained from different vaccine groups in Anopheles stephensi.

Medical Condition: 

Research: Duration of the mosquitocidal effect of ivermectin

October 23, 2012 - 15:43 -- Bart G.J. Knols
Author(s): 
Guido J.H. Bastiaens, Geert-Jan van Gemert, Jo Hooghof, Steve W. Lindsay, Chris Drakeley, Thomas S. Churcher, Jan Peter Verhave, Clemens H.M. Kocken, Robert W. Sauerwein, Teun Bousema
Reference: 
MWJ 2012, 3, 10

Ivermectin (IVM) reduces the lifespan of malaria-transmitting mosquitoes after feeding on humans treated with IVM but limited data are available on the exact duration of the mosquitocidal effect of IVM. Daily mosquito feeding assays were conducted to determine this. Mosquito mortality was 70-100% when mosquitoes fed on mice, rats, or cynomolgus monkeys 1-2 days after the last IVM administration. The findings reported here, of a pronounced but short-lived mosquitocidal effect, makes the timing of IVM administration crucial to form a useful addition to anti-malarial drugs.

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